Navigation Links
JDRF funded researchers test topical drug to treat diabetic macular edema
Date:3/24/2010

NEW YORK, March 24, 2010 Early-stage human clinical trials showed that a new topical drug was safe and had biological effects in a type of diabetic eye disease, and may offer researchers a new approach to prevent and treat diabetic macular edema.

Researchers at the Wilmer Eye Institute of Johns Hopkins University School of Medicine in Maryland completed a multicenter human clinical trial treating diabetic macular edema with mecamylamine, a topical drug developed by the South San Francisco biotech company CoMentis, Inc. Funding for the study was provided by the Juvenile Diabetes Research Foundation (JDRF) through its Industry Drug Development Partnership program. The results were published in the American Journal of Ophthalmology.

Diabetic macular edema is a complication of a specific region of the retina in the eye, called the macula, that develops when small blood vessels become leaky such that fluid accumulates. Without treatment, diabetic macular edema can cause vision impairment, blurriness, or blindness. Therapies to free people from the devastating health burden of complications that can accompany diabetes, including diseases of the eye, nerves, and kidneys, are an important focus of JDRF research; in the last fiscal year, the foundation invested more than $22 million in research involving Complications Therapies.

In the Johns Hopkins study, participants with diabetic macular edema were asked to give themselves mecamylamine eye drops twice a day for 16 weeks. (Preclinical research with diabetic mice showed that mecamylamine had the ability to stop the process that contributed to the development and progression of diabetic macular edema.) Based on these preclinical results, the researchers at Hopkins were interested in measuring both the safety and efficacy of this drug in patients. Every four weeks, trial participants met with researchers to receive a complete eye exam to monitor and track changes to the eye.

'/>"/>
Contact: Jillian Lubarsky
jlubarsky@jdrf.org
212-479-7626
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. JDRF-funded research advances potential for regeneration as a possible cure for type 1 diabetes
2. Emission capture study funded for paper industry
3. Stimulus-funded university research addressing issues from climate change to cancer, creating jobs and training a new generation of scientists
4. 57 college presidents declare support for public access to publicly funded research in the US
5. JDRF-funded studies show regular CGM use increases diabetes control for all age groups
6. NIH-funded researchers sequence exomes of 12 people
7. Recovery act-funded research projects aid communities across the country
8. DOE-funded research projects win 46 R&D 100 Awards for 2009
9. The first DFG research centers to be funded for another four years
10. NASA-funded carbon dioxide map of US released on Google Earth
11. NSF-funded workshops help young researchers teach science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... Research and Markets has announced the addition ... Analysis Size Share Growth Trends and Forecast to 2019" ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number of ... high level security in both private and public sector. ... and passwords, tokens etc. are vulnerable to attacks. Biometrics ...
(Date:7/11/2014)... of all vertebrates, information is transmitted through synapses, ... signal to be passed from one brain cell ... abundant type of synapse, can be either excitatory ... memory, perception and cognition, and the balance between ... For instance, every time we learn something, ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2
... HILO, HawaiiIn collaboration with Stanford University and ... Service Pacific Southwest Research Station,s Institute of Pacific ... developing "hybrid ecosystems"a mix of native and non-native ... in tropical forests. The research team, comprised ...
... parrots and iguanas may seem inoffensive at first glance when ... escape and become invasive species. This has been confirmed by ... 63 Spanish zoos. Birds are the animals most likely to ... (non-indigenous) species, they could become an entry channel for these ...
... -- Specialized white blood cells called T cells and ... and eliminate "non-self" substances such as viruses and bacteria. ... immunoreceptors on the cell surface bind to specific regions on, ... pathways inside the T cells and B cells that control ...
Cached Biology News:US Forest Service and 2 universities team up to develop new ecosystems for Hawaiian forests 275 percent of Spanish zoos at risk of exotic animals escaping 275 percent of Spanish zoos at risk of exotic animals escaping 3
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... basis of psychiatric disorders has been extremely challenging because ... but are insufficient to cause disease. Now investigators reporting ... journal Cell Stem Cell describe a strategy ... interact with other risk factors or environmental exposures to ... pinpoints a genetic variant that may predispose individuals to ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:1/15/2014)... "The interface is the device," Nobel laureate Herbert ... to be found at the junctures where layers ... of nanotechnology, the interfaces between layers of metal ... such high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3A deeper look at interfaces 2
... ANGELES, Feb. 18 The Board of Directors wishes to ... 2009 it resolved to file a Form 15 with effect ... the approval of stockholders but in the interests of keeping ... Release.The effect of this filing is to release the company ...
... SAN DIEGO, Feb. 18 Zogenix, Inc. ("Zogenix"), a ... Drug,Administration (FDA) has provided a target date of July ... for Sumavel DosePro (sumatriptan,injection) needle-free delivery system. Zogenix ... treatment of migraine attacks with or without,aura, and the ...
... Inc. (the "Company") (Nasdaq: PDGI ), a ... biotechnology, generic drug and medical device companies, today announced ... Brazil to further enhance its Latin American presence.PharmaNet has ... 2002 with a network of field-based staff in Brazil, ...
Cached Biology Technology:EESTECH Inc - Release From SEC Filing 2EESTECH Inc - Release From SEC Filing 3EESTECH Inc - Release From SEC Filing 4Zogenix Reports FDA Provides New PDUFA Date for Sumavel(TM) DosePro(TM) 2PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 2PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 3PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 4PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 5
Recombinant Equine IL-6...
... two highly efficient methods of identifying recombinant ... By using the large-scale screen method in ... is to transfer partial colonies of E. ... into the solutions provided by the kits ...
... Fernandez and G. Butcher (1998). • The ... much research in the immunology area. There ... MHC proteins and in their function as ... faced with the prospect of tackling biochemical ...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Biology Products: