Navigation Links
JDRF-funded researchers discover proteins regulating human beta cell replication
Date:1/16/2009

NEW YORK, January 16, 2009 - Researchers at the University of Pittsburgh School of Medicine, funded by JDRF, have discovered that adult beta cells have the ability to replicate with the help of a protein known as cdk6. This research was led by Andrew F. Stewart, M.D., a Professor of Medicine and Chief of the Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine. The complete findings of this discovery can be found in the early online version of Diabetes.

"Most scientists thought that these important pancreatic cells could not be induced to regenerate, or could only replicate very slowly," explained Dr. Stewart. "This work provides proof-of-principle that the production of human beta cells can be stimulated, and that those newly-generated cells function effectively both in the lab and in a living animal."

The ability of cells including human beta cells to divide or replicate is controlled by a series of events known as the cell cycle or cell division cycle. Pittsburgh researchers have taken steps to map comprehensively the proteins regulating the cell cycle in human beta cells. They examined 34 different proteins and found that cyclin dependent kinase- 6 (cdk6) alone or with cyclin D, when injected into human islets by viral delivery methods, triggered the beta cells to replicate. These transduced islets were then transplanted into diabetic mice for six weeks. The transplanted islet cells with cdk6 and cyclin D performed better than control (non-modified) human islets as measured by blood glucose levels and glucose tolerance tests in the transplanted animals. Researchers removed the transplanted cells after the six week study and confirmed that the human beta cells replicated in the transplant model.

"The question as to whether and how human beta cells can be induced to proliferate is a fundamentally important one for JDRF's Regeneration Program. Dr. Stewart and his colleagues address t
'/>"/>

Contact: Jillian Lubarsky
jlubarsky@jdrf.org
212-479-7626
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Page: 1 2

Related biology news :

1. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
2. Researchers identify proteins involved in new neurodegenerative syndrome
3. Texas researchers and educators head for Antarctica
4. MGH researchers describe new way to identify, evolve novel enzymes
5. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. UIC researchers find promising new targets for antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... in Peru found that 28 percent of the ... falsified. Many pills released the active ingredient too ... batch had no active ingredient at all. ... the Georgia Institute of Technology developed a sophisticated ... counterfeit drugs and then characterize their chemical composition. ...
(Date:4/18/2014)... 20 years, researchers have published soil organic carbon sequestration ... that soil organic carbon can be sequestered by simply ... systems. However, there is a growing body of research ... rotations without cover crops, small grains, and forages may ... published rates. , "Some studies have shown that both ...
(Date:4/18/2014)... R.I. [Brown University] Asteroid and comet impacts can ... on regional or even global scales. But new research ... the signatures of ancient life at the time of ... geologist Pete Schultz has found fragments of leaves and ... several ancient impacts in Argentina. The material could provide ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
... July 26, 2012 Congenital hypothyroidism is thyroid hormone ... to neurocognitive impairments in infants and children. Although ... daily during pregnancy for normal fetal thyroid hormone production ... 1,100 g to be the safe upper limit for ...
... Trench is the deepest feature of the Earth,s surface. ... than one thousand times normal atmospheric pressure at sea ... organisms thrive in this seemingly inhospitable environment. A Japanese ... to such high-pressure conditions. They have identified a structural ...
... new study by York University researchers finds that songbirds follow ... with some birds departing on precisely the same date ... PLoS ONE , is the first to track the migration ... outfitted wood thrushes with tiny geolocator "backpacks," recording data on ...
Cached Biology News:Study associates excess maternal iodine supplementation with congenital hypothyroidism in newborns 2Delving into the molecular mechanism behind deep-sea bacteria's pressure tolerance 2It's a bird, not a plane: York U study finds migrating songbirds depart on time 2
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
(Date:1/14/2014)... 2014 In recent years, growing suspicion ... in product development and promotion has led to unprecedented ... fueled by concerns about the insidious impact of commercialization ... spectacular fines to the world’s biggest pharmas for illegal ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... SUMMIT and TOKYO, February 4 Bluegiga,announced today ... with,Bluetooth Health Device Profile (HDP). The Health Device ... the Bluegiga,module, significantly simplifying and reducing the need ... health or medical device. , ...
... model isn,t your father,s nanocar. It runs cool. , The ... versions of their creation have the ability to roll at ... be years away, the breakthrough suggests they,ll be easier to ... which had to be heated to 200 degrees Celsius before ...
... high-performing cold weather biodieselSAN FRANCISCO, Feb. 3 /PRNewswire/ ... producer of small-to-medium scale biodiesel production equipment and ... the release of "Greenline Tea FASTRACK ", ... of materials with a new equipment and process ...
Cached Biology Technology:Bluegiga Provides Health Device Profile for its Bluetooth OEM Modules 2Rice rolls out new nanocars 2Rice rolls out new nanocars 3New Greenline Tea FASTRACK Solves Cold-Flow Issues 2
... Non-ionic Detergent Removal , , ... virtually no cross-reactivity with other proteins , ... , Economical new surface technology, not ... often interfere with protein analysis. SurfactAway offers ...
SDS-OutT SDS Precipitation Reagent...
... a platform for fully automated systems for ... easily be configured for applications ranging from ... allows closed loop screening, which means it ... generating, cherry picking and follow up studies ...
... The Staccato Series of systems provide fast and reliable ... and drug development laboratories. Staccato systems are available in ... Custom Systems Series. ... All ...
Biology Products: