Navigation Links
JDRF funded research shows promise for prevention, reversal of type 1 diabetes
Date:11/18/2008

New York, NY, November 18, 2008 -- Researchers at the University of California, San Francisco have reported that two common cancer drugs have been used to block and reverse type 1 diabetes in mice. The JDRF-funded study, published in The Proceedings of the National Academy of Sciences, was led by Jeffrey Bluestone, Ph.D., director of the Diabetes Center at UCSF and an expert in the field of autoimmunity.

"The findings suggest that kinase inhibitors successfully used in cancer may provide an important new therapeutic approach for treatment of new onset type 1 diabetes and potentially other autoimmune disorders," said JDRF Director of Immunology Teodora Staeva, Ph.D.

The drugs Imatinib and Sunitnib, sold as Gleevec and Sutent, respectively are used to treat cancer by blocking tyrosine kinases, an enzyme that modify cells' signaling proteins through a simple biochemical change. Kinases trigger cell growth, and it is widely believed that tyrosine kinases are a contributing factor to autoimmune diseases and cancer. The researchers hypothesized that tyrosine kinases may also serve as a trigger to the body's attack on the immune system.

The researchers at the University of California, San Francisco treated non-diabetic mice prone to developing diabetes with imatinib or sunitinib, and found that the drugs prevented the onset of diabetes past the seven-week treatment. Mice that already developed diabetes were treated with the drugs and results concluded that after two months of treatment, 80 percent no longer had diabetes.


'/>"/>

Contact: Jillian Lubarsky
jlubarsky@jdrf.org
212-479-7626
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Page: 1

Related biology news :

1. Mandate for public access to NIH-funded research poised to become law
2. Irritating smells alert special cells, NIH-funded study finds
3. OSU technologies funded for development
4. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
5. JDRF funded study links hygiene hypothesis to diabetes prevention
6. Research shows skeleton to be endocrine organ
7. Newly created cancer stem cells could aid breast cancer research
8. Dominant cholesterol-metabolism ideas challenged by new research
9. Researchers identify proteins involved in new neurodegenerative syndrome
10. Texas researchers and educators head for Antarctica
11. MGH researchers describe new way to identify, evolve novel enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces its ... new website makes it easy to navigate through the site whether you’re in ... detailed product information, educational industry content and visit the company’s social media accounts, ...
(Date:8/11/2017)... ... August 11, 2017 , ... A staple in the ... month that will incorporate important key elements including a new digital marketing strategy and ... has supported them, Bill Miller has partnered with the South Texas Blood & Tissue ...
(Date:8/10/2017)... (PRWEB) , ... August 09, 2017 , ... ... regenerative medicine applications in the clinic is here. The team at Capricor Therapeutics, ... in conditioned medium for clinical studies. , Dr. Travis Antes, head of ...
(Date:8/10/2017)... ... August 10, 2017 , ... SPIE, ... Company Ltd. as its exclusive sales representative for SPIE Journals in Japan. Kinokuniya ... SPIE Digital Library in Japan. , “We look forward to expanding our relationship ...
Breaking Biology Technology: