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JCI table of contents: Feb. 21, 2011
Date:2/21/2011

acytoid dendritic cells defines a persistently IFN-alphaproducing and partially matured phenotype

AUTHOR CONTACT:
Nina Bhardwaj
New York University School of Medicine, New York, New York, USA.
Phone: 212.263.5814; Fax: 212.263.6729; E-mail: Nina.Bhardwaj@nyumc.org.

View this article at: http://www.jci.org/articles/view/44960?key=eea0f21f81ff48e26de2


VIROLOGY: Secrets about virus-induced immune cell cancers revealed

Kaposi sarcoma herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (a cancer that develops from the cells that line lymph or blood vessels). It has also been linked to primary effusion lymphoma and multicentric Castleman disease, which are poorly understood and largely incurable cancers that arise from immune cells known as B cells. Two independent research groups (one led by Don Ganem, at the University of California, San Fransisco, and the other led by Ethel Ceserman, at Weill Cornell Medical College, New York) have now generated new insight into how KSHV infection of B cells is regulated and how this affects B cell function and causes disease.

In an accompanying commentary, Chris Boshoff, at University College London, United Kingdom, discusses further the importance of these two papers for understanding KSHV-induced B cell cancers.

TITLE: Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells

AUTHOR CONTACT:
Don Ganem
University of California at San Fransisco, San Francisco, California, USA.
Phone: 415.476.2826; Fax: 415.476.0939; Email: don.ganem@ucsf.edu.

View this article at: http://www.jci.org/articles/view/43755?key=6edef
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
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