New York University School of Medicine, New York, New York, USA.
Phone: 212.263.5814; Fax: 212.263.6729; E-mail: Nina.Bhardwaj@nyumc.org.
View this article at: http://www.jci.org/articles/view/44960?key=eea0f21f81ff48e26de2
VIROLOGY: Secrets about virus-induced immune cell cancers revealed
Kaposi sarcoma herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (a cancer that develops from the cells that line lymph or blood vessels). It has also been linked to primary effusion lymphoma and multicentric Castleman disease, which are poorly understood and largely incurable cancers that arise from immune cells known as B cells. Two independent research groups (one led by Don Ganem, at the University of California, San Fransisco, and the other led by Ethel Ceserman, at Weill Cornell Medical College, New York) have now generated new insight into how KSHV infection of B cells is regulated and how this affects B cell function and causes disease.
In an accompanying commentary, Chris Boshoff, at University College London, United Kingdom, discusses further the importance of these two papers for understanding KSHV-induced B cell cancers.
TITLE: Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells
University of California at San Fransisco, San Francisco, California, USA.
Phone: 415.476.2826; Fax: 415.476.0939; Email: firstname.lastname@example.org.
View this article at: http://www.jci.org/articles/view/43755?key=6edef
|Contact: Ushma Neill|
Journal of Clinical Investigation