Sergio D. Rosenzweig
NIAID, NIH, Bethesda, Maryland, USA.
Phone: 301.451.8971; Fax: 301.451.7901; E-mail: firstname.lastname@example.org.
View this article at: http://www.jci.org/articles/view/44182?key=6b81894e21816f2823dd
TITLE: Genetic control of hepatitis A severity and susceptibility to allergy
INSERM U1013, Hpital Necker Enfants Malades, Paris, France.
Phone: 33.1444953.73; Fax: 33.1430623.88; E-mail: email@example.com.
View this article at: http://www.jci.org/articles/view/46418?key=78670636caec9be10289
VIROLOGY: HIV-1 takes control of its own destiny
Both animal and human studies suggest that the immune molecule IFN-alpha has a role in the progression of disease in individuals infected with HIV-1. A team of researchers, led by Nina Bhardwaj, at New York University School of Medicine, New York, has now determined that HIV-1 itself is able to skew immune cells known as pDCs toward a state in which they persistently secrete IFN-alpha and uncovered the mechanism by which it does this. The team suggests that by skewing pDCs to a persistently IFN-asecreting state, HIV-1 may promote its own survival and thereby disease progression. The team also suggests that even greater understanding of the pDC/HIV-1 interaction could elucidate new therapies for HIV-1 disease.
TITLE: Spatiotemporal trafficking of HIV in human plasm
|Contact: Ushma Neill|
Journal of Clinical Investigation