Navigation Links
JCI table of contents: Feb. 21, 2011
Date:2/21/2011

rophic cardiomyopathy: getting into and out of the thick of it

AUTHOR CONTACT:
Bruce D. Gelb
Mount Sinai School of Medicine, New York, New York, USA.
Phone: 212.241.3302; Fax: 212.241.3310; E-mail: bruce.gelb@mssm.edu.

View this article at: http://www.jci.org/articles/view/46399?key=b94279a9b368432e4ab3


VIROLOGY: The genetic variant that increases the severity of hepatitis A virusinduced disease is

Infection with hepatitis A virus usually results in asymptomatic infection or mild disease. However, in a small subset of patients it can lead to severe disease and even liver failure. A team of researchers, led by Dale Umetsu, at Children's Hospital, Harvard Medical School, Boston, and Sergio Rosenzweig, at Hospital Nacional de Pediatra J. P. Garrahan, Argentina, have now identified a form of the TIM1 gene (which generates the protein to which hepatitis A virus binds as it enters cells) that is associated with severe hepatitis A virusinduced liver disease. Surprisingly, this form of the gene has previously been associated with protection against asthma and allergic diseases. The authors therefore suggest that infection with hepatitis A virus has driven the natural selection of forms of the TIM-1 protein that bind hepatitis A virus less efficiently, thereby protecting against severe hepatitis A virusinduced disease, but which may predispose toward inflammation associated with asthma and allergy.

In an accompanying commentary, Lucienne Chatenoud and Jean-Franois Bach, at Hpital Necker Enfants Malades, France, discuss the importance of this paper and highlight the novel concepts it introduces.

TITLE: A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans

AUTHOR CONTACT:
Dale T. Umetsu
Children's Hospita
'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Keck Foundation funds work on tiny, implantable computers to restore lost brain functions
2. Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation
3. Female lizard turns the table: Why exaggerated coloration makes her a good mate
4. With chemical modification, stable RNA nanoparticles go 3-D
5. JCI online early table of contents: Jan. 4, 2011
6. Paper mulches evaluated for commercial vegetable production
7. Goji berries have the same nutrients as fruits and vegetables and a placebo effect
8. Atomic weights of 10 elements on periodic table about to make an historic change
9. GEN co-sponsors roundtable discussion on novel bioremediation techniques
10. Towards an efficient, effective and equitable REDD+
11. Jefferson researchers receive W.W. Smith Charitable Trust
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ...
(Date:12/15/2014)... Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) has announced the ... report to their offering. ... technology used for the identification of individuals. Facial recognition ... such as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays a ... while. Hypertension – the medical term for high blood pressure ... 1800s, and the inflatable cuff that,s used in measuring blood ... mean there,s nothing new about hypertension, its triggers and its ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... Energy. This trio of problems is among ... Water purification alone is becoming more problematic in ... sources, such as polluted rivers, lakes and groundwater. , ... Rittmann, director of the Center for Environmental Biotechnology in ...
... Fruit lovers worldwide may soon enjoy new, healthier, tastier ... data which fruit breeders say will help revolutionise the ... fruit science company HortResearch, announced today that they would ... collection of apple DNA sequences. , The release comprises ...
... the Max Planck Institute for Dynamics and Self-Organization ... Göttingen together with the neurophysiologist Maxim Volgushev from ... the nerve cells in the cerebral cortex decide ... that the high flexibility and speed with which ...
Cached Biology News:Earth Rx: A microbial biotechnology prescription for global environmental health 2Earth Rx: A microbial biotechnology prescription for global environmental health 3HortResearch science reveals the natural potential of apples 2Why nerve cells work faster than the theory allows 2Why nerve cells work faster than the theory allows 3Why nerve cells work faster than the theory allows 4
(Date:1/22/2015)... DE (PRWEB) January 22, 2015 Controlled ... Pistoia Alliance, which helps companies check the legal requirements ... to expand to China. , As their international ... are globally adopting software solutions built as a result ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... /PRNewswire/ - Cytochroma today announced that it has appointed ... Company,s Scientific Advisory Board. , Dr. Cunningham is Professor ... Consultant Nephrologist at the Royal Free Hospital, London. His ... postgraduate training in The University of London and ...
... Oct. 15 /PRNewswire-Asia/ -- Sundia MediTech, a leading,pharmaceutical R&D ... D. Maher has been appointed Senior Vice President of ... Prior to joining Sundia, Mr. Maher was Executive Vice ... Group, a CRO company in,Florida, USA. Azopharma,s CRO ...
... Calif., Oct. 15 BlueFire Ethanol Fuels, Inc. (OTC ... world,s transportation fuel paradigm through the production of ethanol ... of its second planned biorefinery to Fulton, Mississippi. ... , After having been awarded a $40 million dollar ...
Cached Biology Technology:Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board 2Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board 3Sundia Appoints Charles D. Maher as Senior Vice President of Sales and Marketing 2Department of Energy Grants BlueFire Approval for Site Change 2Department of Energy Grants BlueFire Approval for Site Change 3Department of Energy Grants BlueFire Approval for Site Change 4
... the first fully automated proteomics workcell. It ... with complete data tracking. It automates the ... through final protein expression and measurement. The ... a plate to any of its instruments ...
... columns is a well-known separation technique in ... are in DNA/RNA extraction in microbiology, viral ... in chemical or analytical laboratories. ,This ... series instruments for smaller scales. The extraction ...
... multi-functional program that searches for ... sequence file for polymerase chain ... mutagenesis, and various hybridization applications. ... secondary structure of oligonucleotides based ...
... structure visualization, phylogenetic tree building, sequence analysis, ... application. Retrieve sequences ... filter them in real-time Organize your ... filtering and sorting Provides up-to-date articles ...
Biology Products: