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JCI table of contents: Feb. 21, 2011
Date:2/21/2011

e also sobering, as they indicate that distinct therapeutic approaches will be required to treat the hypertrophic cardiomyopathy associated with different genetic mutations that affect the Ras signaling pathway.

TITLE: MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

AUTHOR CONTACT:
Benjamin G. Neel
Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Phone: 416.581.7726; Fax: 416.581.7698; E-mail: bneel@uhnresearch.ca.

Toshiyuki Araki
Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Phone: 416.581.7726; Fax: 416.581.7698; E-mail: taraki@uhnres.utoronto.ca.

View this article at: http://www.jci.org/articles/view/44929?key=8b3664dc592d4ec23214

ACCOMPANYING ARTICLE
TITLE: Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndromeassociated PTPN11 mutation

AUTHOR CONTACT:
Maria I. Kontaridis
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Phone: 617.735.4248; Fax: 617.735.4255; E-mail: mkontari@bidmc.harvard.edu.

Benjamin G. Neel
Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Phone: 416.581.7710; Fax: 416.581.7698; E-mail: bneel@uhnresearch.ca.

View this article at: http://www.jci.org/articles/view/44972?key=d41da5d8008437f07737

ACCOMPANYING COMMENTARY
TITLE: RAS signaling pathway mutations and hypert
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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