Navigation Links
JCI table of contents: Feb. 21, 2011
Date:2/21/2011

e also sobering, as they indicate that distinct therapeutic approaches will be required to treat the hypertrophic cardiomyopathy associated with different genetic mutations that affect the Ras signaling pathway.

TITLE: MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

AUTHOR CONTACT:
Benjamin G. Neel
Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Phone: 416.581.7726; Fax: 416.581.7698; E-mail: bneel@uhnresearch.ca.

Toshiyuki Araki
Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Phone: 416.581.7726; Fax: 416.581.7698; E-mail: taraki@uhnres.utoronto.ca.

View this article at: http://www.jci.org/articles/view/44929?key=8b3664dc592d4ec23214

ACCOMPANYING ARTICLE
TITLE: Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndromeassociated PTPN11 mutation

AUTHOR CONTACT:
Maria I. Kontaridis
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Phone: 617.735.4248; Fax: 617.735.4255; E-mail: mkontari@bidmc.harvard.edu.

Benjamin G. Neel
Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Phone: 416.581.7710; Fax: 416.581.7698; E-mail: bneel@uhnresearch.ca.

View this article at: http://www.jci.org/articles/view/44972?key=d41da5d8008437f07737

ACCOMPANYING COMMENTARY
TITLE: RAS signaling pathway mutations and hypert
'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Keck Foundation funds work on tiny, implantable computers to restore lost brain functions
2. Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation
3. Female lizard turns the table: Why exaggerated coloration makes her a good mate
4. With chemical modification, stable RNA nanoparticles go 3-D
5. JCI online early table of contents: Jan. 4, 2011
6. Paper mulches evaluated for commercial vegetable production
7. Goji berries have the same nutrients as fruits and vegetables and a placebo effect
8. Atomic weights of 10 elements on periodic table about to make an historic change
9. GEN co-sponsors roundtable discussion on novel bioremediation techniques
10. Towards an efficient, effective and equitable REDD+
11. Jefferson researchers receive W.W. Smith Charitable Trust
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... LAKES , N.J. and NEW YORK ... Company) and Guidepoint today announced BD ... start-up healthcare companies with free access to Guidepoint,s expert ... several start-ups that are developing cutting-edge technologies to improve ... a dedicated Guidepoint research manager, each start-up entrepreneur will ...
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... detected from space for the first time using optical ... aboard Envisat. The ability to monitor Sargassum globally will ... the ocean and better predict climate change. Credit: ESA ... ships in its dense floating vegetation, has been detected ...
... are moving closer to understanding why the most lethal ... treatment in the past three decades. They have been ... a protozoan gene that contributes to such resistance. And ... constructed over a two-year period is believed to be ...
... postdoctoral fellow at the University of Oregon, has shown that ... soil bacteria needed to provide a natural fertilizer to crops. ... boost crop yields may instead be contributing to growth problems, ... years of research both in the test tube and, now, ...
Cached Biology News:Envisat captures first image of Sargassum from space 2Largest synthetic gene ever built offers insights into anti-malarial drug resistance 2Largest synthetic gene ever built offers insights into anti-malarial drug resistance 3Largest synthetic gene ever built offers insights into anti-malarial drug resistance 4Pesticides choke pathway for nature to produce nitrogen for crops 2Pesticides choke pathway for nature to produce nitrogen for crops 3
(Date:7/30/2015)... , July 30, 2015   GenoSpace , ... the interpretation and analysis of genomic and other ... has joined the company as Vice President ... http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace partners ... integrate, interpret, analyze and explore complex sets of ...
(Date:7/30/2015)... , July 30, 2015 ... by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial Design, ... & Development, Preclinical, Clinical Trial), by End Users - ... Market is expected to reach USD 2,107.99 million by ... CAGR of 15.29%. Browse more than ...
(Date:7/30/2015)... , Inc. (NASDAQ: SNMX ), a leading company ... commercialize novel flavor ingredients for the food, beverage, and ... second quarter 2015. "Moving into the ... achieve our commercial and financial goals," stated John Poyhonen, ... our last quarterly earnings report, our two partners have ...
(Date:7/30/2015)... HIGHLIGHTS:Q2 2015 Results (all changes are against ... were $697 million compared to $701 million in the ... and changes in foreign currency exchange rates decreased sales ... , By business unit, organic sales growth was 6% ... Commercial. , Reported diluted EPS was $0.98 compared ...
Breaking Biology Technology:GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20
... sets the new global standard to eradicate ... in health care facilities, including MRSA and ... ... BioNeutral announces successful,testing of its Ygiene(TM) Hospital Grade antimicrobial against,antibiotic-resistant microorganisms ...
... Xceed Molecular, a pioneer in,the development of ... has selected the company,s Ziplex,System as a recipient ... Oscars of Invention by The Chicago Tribune, the ... mark of excellence known to industry,government, and academia ...
... SEATTLE and OSLO, Norway, Aug. 19 ... Affitech AS, a,Norwegian human antibody therapeutics company, ... agreement for the discovery and development of ... or mannan-binding,lectin-associated serine protease-2, mediates activation of ...
Cached Biology Technology:BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 2BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 3BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 4Xceed Ziplex(R) System for Automated Gene-Expression Analysis Wins 2008 R&D 100 Award 2Affitech and Omeros Enter Into Antibody Discovery and Development Agreement 2Affitech and Omeros Enter Into Antibody Discovery and Development Agreement 3
... does for enzyme-/substrate-based blotting what intensifying screens do ... up to 10-fold (or one order of magnitude) ... Signal Enhancer membrane treatment is a simple, 15-minute ... current Western blotting protocol. The result is an ...
...
... Expression is a revolutionary new ... analysis. Utilising a novel interface, Expression ... information incredibly simple. Expression uses the ... new standards in the way sequences ...
... Solution is a comprehensive suite of ... specifically designed to reliably extract biological ... genomic studies containing thousands of samples, ... efficient and will analyze large data ...
Biology Products: