Navigation Links
JCI table of contents: Feb. 21, 2011
Date:2/21/2011

a33

ACCOMPANYING COMMENTARY
TITLE: Upper urinary tract pacemaker cells join the GLI club

AUTHOR CONTACT:
Doris Herzlinger
Cornell University Medical College, New York, New York, USA.
Phone: 212.746.6377; Fax: 212.746.8690; E-mail: daherzli@med.cornell.edu.

View this article at: http://www.jci.org/articles/view/46400?key=0a5cc11ee8d53fbb71cb


CARDIOLOGY: Possible new approach to treating two related multi-organ syndromes

LEOPARD syndrome and Noonan syndrome are two genetic conditions caused by mutations that affect the Ras signaling pathway. Individuals with either of these syndromes have a range of symptoms that often includes the potentially fatal heart condition hypertrophic cardiomyopathy. By generating and studying new mouse models of LEOPARD syndrome and Noonan syndrome, two teams of researchers have identified new ways in which the hypertrophic cardiomyopathy associated with these syndromes could perhaps be prevented or reversed with small-molecule inhibitors.

The team led by Benjamin Neel and Toshiyuki Araki, at University Health Network, Toronto, Canada, found that the hypertrophic cardiomyopathy associated with their new mouse model of Noonan syndrome was reversed by treatment with an inhibitor of the Ras signaling pathway component MEK. By contrast, the team led by Maria I. Kontaridis, at Beth Israel Deaconess Medical Center, Boston, and Benjamin Neel found that the hypertrophic cardiomyopathy associated with their new mouse model of LEOPARD syndrome was completely reversed by treatment with rapamycin, an inhibitor of the signaling protein mTOR.

As noted by Bruce Gelb and Marco Tartaglia, in an accompanying commentary, while the data generated by the two teams are exciting, because they suggest realistic therapeutic targets, they ar
'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Keck Foundation funds work on tiny, implantable computers to restore lost brain functions
2. Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation
3. Female lizard turns the table: Why exaggerated coloration makes her a good mate
4. With chemical modification, stable RNA nanoparticles go 3-D
5. JCI online early table of contents: Jan. 4, 2011
6. Paper mulches evaluated for commercial vegetable production
7. Goji berries have the same nutrients as fruits and vegetables and a placebo effect
8. Atomic weights of 10 elements on periodic table about to make an historic change
9. GEN co-sponsors roundtable discussion on novel bioremediation techniques
10. Towards an efficient, effective and equitable REDD+
11. Jefferson researchers receive W.W. Smith Charitable Trust
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Conservation Society shows that no-take zones in Belize ... as lobster, conch, and fish recover from overfishing, ... , The reporttitled "Review of the Benefits of ... from no-take areas around the world. The report ... expert in marine protected areas and fisheries management. ...
(Date:7/11/2014)... at the Department of Energy,s Oak Ridge National ... by R&D Magazine in recognition of the year,s ... the tremendous value of our National Labs," said ... at the National Labs continues to help our ... scientific and technological innovations necessary to remain globally ...
(Date:7/11/2014)... in eastern New South Wales, Australia when NASA,s Aqua ... UTC on July 11 (12:35 p.m. local time/11:35 p.m. ... New South Wales (NSW), the Moderate Resolution Imaging Spectroradiometer ... region and spotted smoke (light brown) from various fires. ... outlined in red. , The New South Wales, Australia ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... new study finds that propofol, a well-known anesthesia medication, has ... imaging studies. The study, led by a pediatric anesthesiologist now ... incidence of adverse events and no long term complications when ... require them to be still for long periods of time. ...
... life, and occurs naturally in soil and ground water in ... been linked to lung, bladder and kidney cancer, and thus ... drinking water. Chemically similar to phosphorus, arsenic forms arsenate (AsO ... 3- ). Arsenate interferes with many phosphate-requiring metabolic reactions, ...
... June 8, 2010 From April 8 to 10, ... Texas, to focus on advancing new tools to humanely ... and dogs. Experts in reproductive biology and other related ... with industry experts in animal health drug development. Veterinary ...
Cached Biology News:Propofol poses low risk in pediatric imaging studies, but risk increases with anesthesia duration 2Arsenic hyperaccumulating ferns: How do they survive? 2Arsenic hyperaccumulating ferns: How do they survive? 3Momentum builds after 4th International Symposium on Pet Contraception 2Momentum builds after 4th International Symposium on Pet Contraception 3
(Date:7/10/2014)... (PRWEB) July 10, 2014 Robert Harman, DVM, ... Medicine company, is proud to announce the relaunch of his ... with a new series called “ What are Stem Cells ... an honest and straightforward foundation in the basics of stem ... decision on the right type of treatment when considering regenerative ...
(Date:7/10/2014)... Senior supply chain management executives from ... the challenges of “Reducing Cost, Lead Time, & Defects ... sourcing. Describing the partnership of the Bio Supply Management ... Institute ( SCMI) of the University of San ... the Kroc Institute of Peace and Justice in San ...
(Date:7/10/2014)... 2014  Kainos Capital, a firm specializing in acquiring ... it has acquired the Slim-Fast brand from Unilever. Unilever ... of the transaction were not disclosed. Slim-Fast ... that markets ready-to-drink shakes, powders, bars and snacks to ... and in the United Kingdom ...
(Date:7/10/2014)... 10, 2014   Ceres, Inc . (Nasdaq: ... announced today financial results for the three months ended ... business. Ceres reported that the company and ... this growing season in Brazil, which concluded in June, ... sorghum evaluation areas for part of the growing season. ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... , , , NEW ... of lipid, glucose and overall energy metabolism. Bile acid activation of the ... muscle and brown fat, thereby conferring resistance to weight gain. Now, a ... 10, Issue 3, Sept. 2, 2009) elaborates on a separate TGR5-regulated mechanism ...
... WOODLANDS, Texas, September 1 Berlin Heart Inc.,reported today that ... EXCOR(R) Pediatric IDE Study after having received unconditional,approval of the ... The Principal Investigator, Dr. Charles Fraser, Chief of ... and Pediatrics,at Baylor College of Medicine said, "We ...
... ST. LOUIS and ROMAINVILLE, France, Sept. 1, 2009 Monsanto Company ... commercial license agreement with France-based Cellectis S.A. (Alternext: ALCLS), a biotechnology ... technology in plants. , , Meganucleases are molecular ... genome of a plant cell, thereby allowing a wide range of ...
Cached Biology Technology:Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity 2Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity 3Major Milestone Achieved - Berlin Heart EXCOR Pediatric IDE Study 2Monsanto Licenses Use of Cellectis' Innovative Genome Modification Technology 2Monsanto Licenses Use of Cellectis' Innovative Genome Modification Technology 3