Navigation Links
JCI table of contents: Aug. 9, 2007
Date:8/13/2007

tps://www.the-jci.org/article.php?id=30525


METABOLISM: Battle of the bulge: what controls how much we eat

In simple terms, individuals become obese if they eat more calories than they burn. However, the molecular pathways that control feeding behavior and cellular energy expenditure are highly complex and not completely understood.

In a study that appears online on August 9 in advance of publication in the September print issue of the Journal of Clinical Investigation, Clay Semenkovich and colleagues from Washington University School of Medicine, St. Louis, show that mice lacking a protein known as FAS in beta-islet cells in the pancreas and in the region of the brain known as the hypothalamus are lean because they eat less and move around more than normal mice. These effects on behavior were associated with decreased signaling in the hypothalamus through a protein known as PPAR-alpha. Administration of a PPAR-alpha agonist into the hypothalamus increased the amount mice lacking FAS specifically in the beta-islet cells and in the hypothalamus ate but did not increase the amount normal mice ate. This study therefore identifies FAS-mediated activation of PPAR-alpha as a molecular pathway controlling feeding behavior in mice.

TITLE: Brain fatty acid synthase activates PPAR-alpha to maintain energy homeostasis

AUTHOR CONTACT:
Clay F. Semenkovich
Washington University School of Medicine, St. Louis, Missouri, USA.
Phone: (314)-362-4454; Fax: (314)-362-7641; E-mail: csemenko@wustl.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=31183


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Highly adaptable genome in gut bacterium key to intestinal health
2. Development of portable infectious disease detector
3. Scientists identify genes responsible for black rot disease in vegetables
4. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
5. Aloe vera coating may prolong freshness, safety of fruits and vegetables
6. Nanotechnology to provide portable genetic risk detection
7. New study shows patients more willing to consider self-injectable HIV therapy than many physicians anticipate
8. Implantable pumps extend lives of patients too sick for transplant
9. Bioengineers create stable networks of blood vessels
10. Portable cocaine sensor developed at UC Santa Barbara
11. Researchers develop portable vein finder for faster, more accurate injections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... wounds could identify the superbug quickly and help prevent infection ... whether wounds or lesions are infected with bacteria and if ... of Edinburgh in collaboration with NHS Lothian, works by taking ... using a strip with electrical sensors that can detect MRSA. ...
... This press release is available in German ... vessels, is a complex process during which different signalling proteins ... growth factor VEGF and the Notch signalling pathway both play ... binding to its receptor, VEGFR2, while the Notch signalling pathway ...
... with a deadly form of brain cancer is linked ... The University of Nottingham have discovered. The study ... Centre as part of a European collaboration could potentially ... to identify youngsters who are at the highest risk ...
Cached Biology News:Tiny electrical sensors could signal faster MRSA diagnosis 2Culprit behind unchecked angiogenesis identified 2Genetic abnormality offers diagnostic hope for children's cancer 2Genetic abnormality offers diagnostic hope for children's cancer 3
(Date:5/5/2015)... VIEW, Calif. , May 5, 2015  23andMe, ... launch of the Lupus Research Study in ... 5,000 individuals with systemic lupus erythematosus, more commonly known ... the genetics of lupus. The effort is also in ... with Lupus Awareness Month in May. Approximately ...
(Date:5/5/2015)... MILFORD, Mass. , May 5, 2015 ... a strategic alliance which offers a first-of-its-kind platform that ... patient access to lab results, transforms the way patients ... Luminate Health provides a HIPAA-compliant ... patients to access, manage, and understand their lab results, ...
(Date:5/5/2015)... -- Reprints Desk, Inc., a Research Solutions (OTCQB: RSSS) ... technical and medical (STM) content, today announced a new ... Research Libraries (ASERL) . ASERL is a ... states. Founded in 1956, ASERL has a long history ... continually changing needs of its member libraries. ...
(Date:5/5/2015)... 05, 2015 Franz Inc ., the ... announced that its flagship product, AllegroGraph, has been named a ... Market Update report. AllegroGraph is a high performance ... industry standards. Graph databases are skyrocketing in popularity and have ... a recent DBMS ranking by DB-Engines. , “We ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3
... Pharmaceutical Inc. (Nasdaq: BMRN ) today announced that ... company update at the Deutsche Bank 34th Annual Health Care ... p.m. ET. Interested parties may access a live audio ... the BioMarin website, www.BMRN.com . A ...
... platform for treatment of Spinal Muscular Atrophy SOUTH PLAINFIELD, ... Inc. (PTC) and the Spinal Muscular Atrophy (SMA) Foundation ... which the SMA Foundation will provide up to $8.5 ... second continuation of the collaboration to fund a series ...
... AND STRENGTHENS ITS SENIOR MANAGEMENT TEAM , ... Systems, Inc. (OTC Bulletin Board: OMCM.OB), a leader in ... today announced that it has strengthened its European presence ... Summa. As Executive Vice President, Europe & Asia/Pacific based ...
Cached Biology Technology:BioMarin to Present at the Deutsche Bank Health Care Conference 2PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration 2PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration 3OmniComm Systems Appoints EDC Veteran Dr. Wolfgang Summa to Executive Vice President, Europe & Asia/Pacific 2OmniComm Systems Appoints EDC Veteran Dr. Wolfgang Summa to Executive Vice President, Europe & Asia/Pacific 3
100 ug affinity purified rabbit anti-JIP-1 polyclonal antibody. Reacts with mouse and rat. Perform well in Western blotting. Other applications have not been tested. Storage Temperature: -20C Shi...
Melanoma Antigen, Family C, 1 (MAGEC1) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: New Recommended Storage: Long term: -20C; Short term: +4...
X box-binding protein 1...
Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss P...
Biology Products: