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JCI table of contents: Aug. 16, 2007
Date:8/16/2007

unction of a population of regulatory immune cells characterized as CD4+CD25+Foxp3+ and known as Tregs. Suppression by Tregs activated by IDO-expressing pDCs was mediated by interactions between programmed cell death 1 (PD1) and its ligands. This mechanism of suppression is distinct from that used by Tregs activated by other stimuli. Importantly, immune suppression in tumor-draining lymph nodes was abrogated by treating mice with both a chemotherapeutic drug and a chemical inhibitor of IDO, but not either agent alone, leading the authors to suggest that combining IDO inhibitors with chemotherapeutic agents might improve the efficacy of chemotherapeutics in individuals with cancer.

TITLE: Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3,-dioxygenase

AUTHOR CONTACT: David H. Munn Medical College of Georgia, Augusta, Georgia, USA. Phone: (706) 721-7141; Fax: (706) 721-8732; E-mail: dmunn@mail.mcg.edu.

Toni Baker Director of Media Relations Medical College of Georgia, Augusta, Georgia, USA. Phone: 706-721-4421; E-mail: tbaker@mcg.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=31911


ONCOLOGY: How tumors prevent immune cell entry

For a number of cancers the presence of immune cells known as an NKT cells in the tumor is associated with a better prognosis. It has therefore been suggested that more aggressive tumors have developed strategies to prevent them from being infiltrated by NKT cells. A new study, which appears online on August 16 in advance of publication in the September print issue of the Journal of Clinical Investigation, shows that this is the case. The pathway used by tumors to prevent NKT cell infiltration might provide researchers with new targets for the
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Contact: Karen Honey
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Journal of Clinical Investigation
Source:Eurekalert

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