JCI table of contents: Aug. 16, 2007(formation in the eye led the authors to ...)

TITLE: Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retina

AUTHOR CONTACT: Timothy Hla University of Connecticut School of Medicine, Farmington, Connecticut, USA. Phone: (860) 679-4128; Fax: (860) 679-1201; E-mail: hla@nso2.uchc.edu.

Christopher DeFrancesco Office of Communications University of Connecticut Health Center, Farmington, Connecticut, USA. Phone: 860-679-3914; E-mail: cdefrancesco@uchc.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=31123

ONCOLOGY: A winning combination for the treatment of cancer

The immune system does not destroy tumors even though they express molecules that should activate immune cells. The immune system is therefore said to be tolerant of the tumors. Several molecules and cell types have been implicated in the induction of immune system tolerance to tumors, including, in mice, a small population of immune cells known as plasmacytoid dendritic cells (pDCs) that produce the enzyme indoleamine 2,3-dioxygenase (IDO) and that are isolated from the lymph nodes that drain the site of the tumor. Now, researchers from the Medical College of Georgia, Augusta, have identified how these mouse IDO-expressing pDCs induce tumor-specific immune tolerance.

In the study, which appears online on August 16 in advance of publication in the September print issue of the Journal of Clinical Investigation, David Munn and colleagues found that mouse IDO-expressing pDCs from tumor-draining lymph nodes directly activate the suppressive f
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