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JCI online early table of contents: Oct. 12, 2009
Date:10/12/2009

EDITOR'S PICK: A balancing act in Parkinson disease: phosphorylation of alpha-synuclein

Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. Previous studies have indicated that phosphorylation of alpha-synuclein at amino acid 129 (Ser129) is a key event in alpha-synucleinmediated nerve cell toxicity. However, Mel Feany and colleagues, at Brigham and Women's Hospital, Boston, have now identified a counterbalancing role in nerve cell protection for phosphorylation of alpha-synuclein amino acid 125 (Tyr125).

In the study, phosphorylation of human alpha-synuclein Tyr125 was detected in Drosophila transgenic for human alpha-synuclein and shown to protect from alpha-synucleinmediated nerve cell toxicity in a Drosophila model of Parkinson disease. That the two phosphorylated amino acids have opposing roles was indicated by the observation that Tyr125 phosphorylation decreased levels of toxic soluble alpha-synuclein oligomers in the Drosophila brain, whereas Ser129 phosphorylation increased them. More importantly, Tyr125 phosphorylation was found to decrease as both humans and Drosophila aged and was reduced in cortical tissue from patients with synucleinopathy dementia with Lewy bodies, a disease related to Parkinson disease. The authors therefore suggest that changes in the balance between Ser129 and Tyr125 phosphorylation which promote nerve cell toxicity and protection, respectively might cause alpha-synucleinmediated nerve cell toxicity in Parkinson disease and related disorders.

TITLE: Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

AUTHOR CONTACT:
Mel B. Feany
Brigham and Women's Hospital, Boston, Massachusetts, USA.
Phone: (617) 525-4405; Fax: (617) 525-4422; E-mail: mel_feany@hms.harvard.edu.

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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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