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JCI online early table of contents: Oct. 10, 2011
Date:10/10/2011


University of Miami Miller School of Medicine, Miami, Florida, USA.
Phone: 305.243.3206; Fax: 305.243.3209; E-mail: cfaul@med.miami.edu.

View this article at: http://www.jci.org/articles/view/46122?key=ce4536293acfd2c8a94b


PULMONARY BIOLOGY: FGF10 helps repair the damaged lung

The cells that line the airways are constantly exposed to potentially toxic agents and microbes. If damaged by any of these potential dangers, the airway lining is rapidly and effectively repaired. Understanding the molecular mechanisms by which the airway lining is repaired could identify new therapeutic approaches to treat individuals with lung diseases. A team of researchers led by Stijn De Langhe, at National Jewish Health, Denver, has now uncovered a key role for the protein FGF10 in repair of the mouse airway lining following naphthalene-induced injury. De Langhe and colleagues suggest that overactivation of the FGF10-dependent cellular and molecular pathways they uncovered might be involved in airway remodeling in response to chronic injury in individuals with asthma, although further studies are required to determine if this is the case.

TITLE: Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury

AUTHOR CONTACT:
Stijn P. De Langhe
National Jewish Health, Denver, Colorado, USA.
Phone: 303.398.1763; Fax: 303.398.1225; E-mail: delanghes@njhealth.org.

View this article at: http://www.jci.org/articles/view/58097?key=8d7cb836453c78b5e965


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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