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JCI online early table of contents: Oct. 10, 2011
Date:10/10/2011


University of Virginia, Charlottesville, Virginia, USA.
Phone: 434.924.5011; Fax: 434.982.4380; E-mail: soz4n@virginia.edu.

View this article at: http://www.jci.org/articles/view/60243?key=bb70257167024a21c8e0


ONCOLOGY: Can we predict tumor spread to the liver?

A common cause of cancer-related death in individuals with colorectal cancer the second leading cause of death from cancer in the United States is spreading of the cancer to the liver. Better understanding of the mechanisms underlying colorectal cancer spread to the liver (a process known as liver metastasis) are needed if this event is to be detected early and if we are to develop therapies to prevent it occurring.

Using a mouse model of colorectal cancer, a team of researchers led by Mien-Chie Hung, at The University of Texas MD Anderson Cancer Center, Houston, has now identified a potential role for the protein APOBEC3G in promoting liver metastasis. Of clinical significance, the APOBEC3G gene was found to be expressed at elevated levels in liver metastatic tumors from individuals with colorectal cancer. Furthermore, the colorectal tumors in these individuals expressed higher levels of the APOBEC3G gene than did colorectal tumors from individuals without liver metastases. Hung and colleagues therefore suggest that analyzing the level of expression of the APOBEC3G gene in an individual's colorectal tumor might help predict the likelihood of their tumor spreading to the liver.

TITLE: APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

AUTHOR CONTACT:
Mien-Chie Hung
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Phone: 713.792.3668; Fax: 713.794.3270; E-mail: mhung@
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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