Navigation Links
JCI online early table of contents: Oct. 10, 2011
Date:10/10/2011

s now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers combine them with inhibitors of the MEK/ERK signaling pathway.

In cases in which tyrosine kinase inhibitors are effective they reduce signaling via both the PI3K/AKT and MEK/ERK signaling pathways. It is thought that KRAS mutant cancers are resistant to tyrosine kinase inhibitors because the mutant KRAS protein can directly activate ERK and PI3K signaling. However, Engelman and colleagues discovered that although mutant KRAS activates ERK signaling in human KRAS mutant colorectal cancers, receptor tyrosine kinases control PI3K signaling. Of potential clinical significance, treating mice xenografted to bear a human KRAS mutant colorectal cancer cell line with a combination of a receptor tyrosine kinase inhibitor and a MEK inhibitor induced tumor regression. These data suggest a way in which receptor tyrosine kinase inhibitors could be used to treat individuals with KRAS mutant colorectal cancers. However, the authors caution that heterogeneity among KRAS mutant cancers means that the approach would not work in all patients with such cancers.

TITLE: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

AUTHOR CONTACT:
Jeffrey A. Engelman
Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.724.7298; Fax: 617.724.9648; E-mail: jengelman@partners.org.

View this article at: http://www.jci.org/articles/view/57909?key=7b5e1cfc10931ff45995


EDITOR'S PICK: New insight into the cellular defects in Huntington disease

Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functi
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
2. Personalized medicine: Innovative online journal leads the way
3. Latin American Science Initiative Puts Tropical Rainforest Diversity Online
4. Smithsonian puts tropical Eastern-Pacific shore fishes online
5. Smithsonian puts tropical eastern Pacific shore fishes online
6. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
7. New online report on massive jellyfish swarms released
8. JCI online early table of contents: Jan. 19, 2009
9. Online collaboration identifies bacteria
10. Free online toolkit provides standard measures for genome and population studies
11. K-State plant pathologists develop online teaching modules used globally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
(Date:4/17/2015)... April 17, 2015 ... and technological advancement to drive biometric systems market ... 2020   According to a recently ... Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... register growth at CAGR of over 22% through ...
(Date:4/13/2015)... YORK , April 13, 2015 ... by TechSci Research, "Global Biometrics Market Forecast & Opportunities, ... register a CAGR of around 14% till 2020. ... governments for large scale implementation and review of ... and launch of new products with greater efficiency, ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... all plants--is the most abundant biological material on ... renewable, plant-based biofuels research. Despite overwhelming interest, scientists ... individual cellulose fibers. , However, recent work from ... Stanford University describes the first real-time observations of ...
... that butterflies experience a great loss in body fat ... in the March issue of the Journal of Lipid ... journal. , "The transformation of a caterpillar to a ... E. Connor of the Oregon Health and Science University ...
... that allows DNA from thousands of genes to be collected ... Utah medical researchers have confirmed that a region on a ... researchers at the U School of Medicine made the finding ... family that has a high occurrence of the disorder and ...
Cached Biology News:Formation of cellulose fibers tracked for the first time 2Butterflies lose body fat during metamorphosis 2Utah researchers confirm chromosome may harbor autism gene 2Utah researchers confirm chromosome may harbor autism gene 3
(Date:4/30/2015)... SureClinical, a leader in cloud-based health ... joined SureClinical’s executive team as Chief Financial Officer. ... executive with over 25 years in leadership roles ranging ... Ms. Morris joins SureClinical from Marrone Bio Innovations (MBI), ... of MBI from its founding in 2006 until 2011, ...
(Date:4/29/2015)... 2015 According to a new ... Product (Portable & Non-Portable), Component (Accelerometer, Proximity Probe, ... Metal & Mining, & Others), & Geography - ... expected to reach $1,453.76 Million by 2020, at ... data tables and 92 figures spread through 205 ...
(Date:4/29/2015)... , April 29, 2015   Doximity , the ... all US doctors as members, announced a new, instant ... "Apply Using Doximity." With one click, all US physicians ... curriculum vitae (CV) for an open job opportunity, and ... Eighty seven percent of physicians are open ...
(Date:4/29/2015)... Poway, CA (PRWEB) April 29, 2015 ... proud to announce that its regenerative stem cell therapy ... founded in 2002, seeking to discover a successful treatment ... ligaments. , In 2003 VetStem signed a worldwide exclusive ... veterinary application, and the first horse was treated in ...
Breaking Biology Technology:Julie I. Morris Joins SureClinical as Chief Financial Officer 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2VetStem Biopharma -Regenerative Cell Therapy has processed over 11,000 samples 2
... media presentations created with Sonic Foundry s Mediasite ... of hosted services, which help organizations capture presentations digitally and ... service platform created exclusively for Mediasite, the companies announced in ... any size and type can leverage the power of rich ...
... Formulatrix Inc. and Bruker AXS ... protein-crystal incubation and imaging products. , ,Crystal Farm, developed ... Partners International , is an integrated product for incubation ... companies design drugs. The system will now work with ...
... the first installment - From the mind to ... - The Wisconsin Technology Council has published ... 24-page publication highlights the states research base, technology-transfer process, ... I-Q Corridor that joins Chicago, Wisconsin and Minneapolis-St. Paul. ...
Cached Biology Technology:BxVideo designs Web hosting service for Sonic Foundry media presentations 2Protein-crystal companies join forces for better imaging process 2WTC launches Wisconsin Life Science magazine 2
Agar, 500 g. Noble Agar.Moisture: < 10%, ash: < 1.6%, EEO (-mr): < 0.450 (pH 8.4). Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
MW5...
From micro to giga sizes, from single prep to high-throughput, Invitrogen's range of plasmid purification kits offers superior performance to match the demands of your downstream application....
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient...
Biology Products: