Navigation Links
JCI online early table of contents: Oct. 10, 2011
Date:10/10/2011

s now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers combine them with inhibitors of the MEK/ERK signaling pathway.

In cases in which tyrosine kinase inhibitors are effective they reduce signaling via both the PI3K/AKT and MEK/ERK signaling pathways. It is thought that KRAS mutant cancers are resistant to tyrosine kinase inhibitors because the mutant KRAS protein can directly activate ERK and PI3K signaling. However, Engelman and colleagues discovered that although mutant KRAS activates ERK signaling in human KRAS mutant colorectal cancers, receptor tyrosine kinases control PI3K signaling. Of potential clinical significance, treating mice xenografted to bear a human KRAS mutant colorectal cancer cell line with a combination of a receptor tyrosine kinase inhibitor and a MEK inhibitor induced tumor regression. These data suggest a way in which receptor tyrosine kinase inhibitors could be used to treat individuals with KRAS mutant colorectal cancers. However, the authors caution that heterogeneity among KRAS mutant cancers means that the approach would not work in all patients with such cancers.

TITLE: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

AUTHOR CONTACT:
Jeffrey A. Engelman
Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.724.7298; Fax: 617.724.9648; E-mail: jengelman@partners.org.

View this article at: http://www.jci.org/articles/view/57909?key=7b5e1cfc10931ff45995


EDITOR'S PICK: New insight into the cellular defects in Huntington disease

Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functi
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
2. Personalized medicine: Innovative online journal leads the way
3. Latin American Science Initiative Puts Tropical Rainforest Diversity Online
4. Smithsonian puts tropical Eastern-Pacific shore fishes online
5. Smithsonian puts tropical eastern Pacific shore fishes online
6. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
7. New online report on massive jellyfish swarms released
8. JCI online early table of contents: Jan. 19, 2009
9. Online collaboration identifies bacteria
10. Free online toolkit provides standard measures for genome and population studies
11. K-State plant pathologists develop online teaching modules used globally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... beginning of the age of dinosaurs, gigantic reptilesdistant relatives ... and others in water and it was thought they ... University of Tennessee, Knoxville, researcher in the thigh of ... , Stephanie Drumheller, an earth and planetary sciences ... Sterling Nesbitt examined 220-million-year-old bite marks in the thigh ...
(Date:9/29/2014)... Growing Demand From Huge ... Security Concerns Continue to Propel Biometrics Market in ... is one of the fastest growing biometrics markets ... majorly in various government projects such as National ... biometrics dominates the country,s biometrics market, with other ...
(Date:9/29/2014)... Oktoberfest is here, and that means ... for a cold one, taking that first ... chemicals have reacted to form compounds that ... Reactions explains why beers get skunky, and ... brews from going bad. Learn all about ...
Breaking Biology News(10 mins):Tooth serves as evidence of 220 million-year-old attack 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3
... 100 scientists worldwide publish joint study in Science , ... the US have been probing the genome of the ... results in some aspects have completely overturned geneticists' traditional ... Science on 2nd September. The general conclusion of the ...
... carry and spread to humans is the focus of ... distinguished professor of biochemistry and head of the department ... how insects protect themselves against infection. They think the ... researchers have made progress in understanding which molecules are ...
... the latest issue of Restoration Ecology finds that in ... Oyster reefs are self-sustaining, and are additionally attractive because ... growth, and contribute to overall ecosystem stability and quality. ... stimulate the oysters' settlement; reefs are therefore able to ...
Cached Biology News:Mouse genome much more complex than expected 2K-State researchers study insects' immune system 2
(Date:9/30/2014)... Calif. , Sept. 30, 2014 FemCap ... women,s health announces its receipt of a patent No: ... menstrual cup has also received FDA clearance in the ... and the CE in Europe. This patent is related to ... with this issuance, the company is releasing FemmyCycle Teen, ...
(Date:9/30/2014)... 30, 2014 Lyme Research Alliance ... Lyme disease research at universities, today announced the awarding ... the identification, treatment and cure for Lyme and other ... the most applications in its history—over 20 grant proposals—a ... we were pleased to receive so many solid applications ...
(Date:9/30/2014)... Georgetown, Mass. (PRWEB) September 30, 2014 ... components, products, and specialty packaging has recently introduced ... BioShell® Suspension Pack . The new insulated ... the cold chain distribution process. UFP Technologies’ BioShell ... use biopharmaceutical bags during storage, handling and shipping. ...
(Date:9/29/2014)... Each year in the US, ... attention. In the military, burn injury is a ... medical care. More than 800 service members sustained ... heal slowly, remain inflamed and often become infected, ... and functionally damaging. While developments in supportive care ...
Breaking Biology Technology:The FemmyCycle 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3Faster Healing with Fewer Scars 2
... wireless bids ,The City of Madison received bids from ... InSite Wireless to build wireless hotspots around the airport ... Monday. The winning vendor will pay the city, county and ... able to charge access fees. Certain local sites could be ...
... OpGen , a company that makes ... individuals, has completed the final stage of its $5 ... on University of Wisconsin-Madison technology, already sells its testing ... will be split between marketing that service and new ...
... that word? It was as popular in Web circles in the ... long and short of it was that the Web was going ... to consumers, either in business or retail. , ,Everybody still in ... would get better prices, and so would consumers. A real win-win ...
Cached Biology Technology:Tech Digest: Madison wireless, angels, Third Wave, Esker, Research Park 2OpGen completes $5 million investment round 2A funny thing happened on the way out of the back office 2A funny thing happened on the way out of the back office 3
Vesicle Associated Membrane Protein (VAMP 1/2)...
...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Biology Products: