Navigation Links
JCI online early table of contents: Oct. 10, 2011
Date:10/10/2011

s now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers combine them with inhibitors of the MEK/ERK signaling pathway.

In cases in which tyrosine kinase inhibitors are effective they reduce signaling via both the PI3K/AKT and MEK/ERK signaling pathways. It is thought that KRAS mutant cancers are resistant to tyrosine kinase inhibitors because the mutant KRAS protein can directly activate ERK and PI3K signaling. However, Engelman and colleagues discovered that although mutant KRAS activates ERK signaling in human KRAS mutant colorectal cancers, receptor tyrosine kinases control PI3K signaling. Of potential clinical significance, treating mice xenografted to bear a human KRAS mutant colorectal cancer cell line with a combination of a receptor tyrosine kinase inhibitor and a MEK inhibitor induced tumor regression. These data suggest a way in which receptor tyrosine kinase inhibitors could be used to treat individuals with KRAS mutant colorectal cancers. However, the authors caution that heterogeneity among KRAS mutant cancers means that the approach would not work in all patients with such cancers.

TITLE: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

AUTHOR CONTACT:
Jeffrey A. Engelman
Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.724.7298; Fax: 617.724.9648; E-mail: jengelman@partners.org.

View this article at: http://www.jci.org/articles/view/57909?key=7b5e1cfc10931ff45995


EDITOR'S PICK: New insight into the cellular defects in Huntington disease

Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functi
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
2. Personalized medicine: Innovative online journal leads the way
3. Latin American Science Initiative Puts Tropical Rainforest Diversity Online
4. Smithsonian puts tropical Eastern-Pacific shore fishes online
5. Smithsonian puts tropical eastern Pacific shore fishes online
6. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
7. New online report on massive jellyfish swarms released
8. JCI online early table of contents: Jan. 19, 2009
9. Online collaboration identifies bacteria
10. Free online toolkit provides standard measures for genome and population studies
11. K-State plant pathologists develop online teaching modules used globally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , July 31, 2015 The 10 th ... be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary this ... of the world,s most influential annual meetings in the ,omics, ... enjoyable scientific gatherings. ICG-10 focuses on recent ...
(Date:7/23/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) ... Outlook of the Biometrics Industry 2015 " ... global biometrics market is likely to witness significant ... to the uptake of multiple technologies available. The ... the growth of biometrics in existing applications as ...
(Date:7/13/2015)... , July 13, 2015 Synaptics ... of human interface solutions, today announced sampling of ... and display driver integration (TDDI) product targeting smartphones ... first to combine Synaptics , best-in-class touch ... display driver technology developed in the company,s Japan ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3
... volume of online scientific data, a new style of ... have a direct impact on scientists and clinicians. ... Biology and Faculty of 1000 Medicine, are each launching ... journals, called F1000 Reports, are unlike existing scientific journals ...
... wide-open spaces of the Flint Hills may no longer ... familiar grassland birds, according to research by a Kansas ... found that three bird species common to the Flint ... population decline in the face of extensive land-management practices ...
... epidemiological study of men and post-menopausal women primarily over ... associated with greater bone mineral density (BMD). Researchers at ... Aging (USDA HNRCA) at Tufts University found associations were ... significantly lower in men drinking more than two servings ...
Cached Biology News:World's experts identify the hottest trends in biology and medicine 2Birds in Flint Hills of Kansas, Oklahoma face population decline despite large habitat 2Birds in Flint Hills of Kansas, Oklahoma face population decline despite large habitat 3Moderate alcohol intake associated with bone protection 2Moderate alcohol intake associated with bone protection 3
(Date:8/3/2015)...  Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will ... quarter 2015 on Monday, August 10, 2015 at 4:30 ... president and chief executive officer, will lead the call. ... results for the second quarter 2015. The ... of Halozyme,s corporate website and a recording will be ...
(Date:8/3/2015)... 2015  ArroGen Group, an integrated advanced forensic ... Identification™ (FMID) technology Aug. 2-8 at the International ... Sacramento, Calif. FMID, a ... enforcement agents, district attorneys and government agencies to ... By analyzing chemical residues on fingerprints taken ...
(Date:8/3/2015)... At the 11th hour, London,s ... of Jude Liversage,s campaign so the seven-year-old ...      (Photo: http://photos.prnewswire.com/prnh/20150803/254228 ) ... The Selective Dorsal Rhizotomy (SDR) procedure reduced the spasticity ... wish to kick a ball around like his schoolmates. ...
(Date:8/3/2015)... Ga. , Aug. 3, 2015  MiMedx Group, ... company utilizing human amniotic tissue and patent-protected processes to ... Wound Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and ... present at the 35 th Annual Canaccord|Genuity Growth ... H. "Pete" Petit, Chairman and CEO, William C. ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2ArroGen Previews New Fingerprint Molecular Identification Technology 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2
... /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI, ... York), a licensee of several small molecule compounds ... of Health (NIH) Small Business Innovation Research (SBIR) ... Phase I awards to develop novel treatments for ...
... a bad rap for contributing to hypertension and cardiovascular disease. ... Sciences have discovered that sodium also plays a key role ... Tufts scientists have found a way to regenerate injured spinal ... an influx of sodium ions into injured cells. ...
... and global contributions to clean water and environmental causes, ... to invention and the pursuit of discovery, Professor Xiaoguang ... Stevens Institute of Technology at the university,s annual Convocation ... professor in the Charles V. Schaefer, Jr. School of ...
Cached Biology Technology:YM BioSciences licensee Pulmokine awarded NIH funding to develop small molecule drugs for pulmonary hypertension 2YM BioSciences licensee Pulmokine awarded NIH funding to develop small molecule drugs for pulmonary hypertension 3Sodium plays key role in tissue regeneration 2Sodium plays key role in tissue regeneration 3Xiaoguang Meng receives honorary master of engineering from Stevens 2Xiaoguang Meng receives honorary master of engineering from Stevens 3
... polymerase from Thermus aquaticus expressed in E. ... tube of 250 units enzyme/tube and Buffer ... is the same enzyme as AmpliTaq DNA ... proprietary separation process to ensure that contaminating ...
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
Taq DNA polymerase, 10,000U...
... AmpliTaq DNA Polymerase is the ... PCR process, a testimony to its overall ... profile makes it ideal for PCR applications. ... guarantee reproducible results. ,, AmpliTaq DNA ...
Biology Products: