Navigation Links
JCI online early table of contents: Oct. 10, 2011
Date:10/10/2011

EDITOR'S PICK: SIRT(ain) benefit of reducing calories

The number of individuals with type 2 diabetes is reaching epidemic proportions. One of the main risk factors for developing type 2 diabetes is resistance of cells in the body (particularly liver, fat, and skeletal muscle cells) to the effects of the hormone insulin. Substantially reducing caloric intake enhances the sensitivity of skeletal muscle to insulin. Defining the molecular signals within skeletal muscle linking caloric restriction to improved insulin action could provide new targets for therapeutics to reduce insulin resistance and thereby lower an individual's risk of developing type 2 diabetes. In this context, a team of researchers led by Jerrold Olefsky, at the University of California at San Diego, La Jolla, has now found that the mouse protein Sirt1 has an integral role within skeletal muscle in linking caloric restriction to improved insulin action. Furthermore, they have identified the downstream molecular mechanism by which Sirt1 translates decreases in nutrient intake into enhanced skeletal muscle insulin sensitivity.

TITLE: Sirt1 enhances skeletal muscle insulin sensitivity in calorie-restricted mice

AUTHOR CONTACT:
Jerrold M. Olefsky
University of California at San Diego, La Jolla, California, USA.
Phone: 858.534.6651; Fax: 858.534.6653; E-mail: jolefsky@ucsd.edu.

View this article at: http://www.jci.org/articles/view/58554?key=9b0889fedb8edc5d63e2


EDITOR'S PICK: Combination therapies for drug-resistant cancers

Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts General Hospital Cancer Center, Boston, ha
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
2. Personalized medicine: Innovative online journal leads the way
3. Latin American Science Initiative Puts Tropical Rainforest Diversity Online
4. Smithsonian puts tropical Eastern-Pacific shore fishes online
5. Smithsonian puts tropical eastern Pacific shore fishes online
6. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
7. New online report on massive jellyfish swarms released
8. JCI online early table of contents: Jan. 19, 2009
9. Online collaboration identifies bacteria
10. Free online toolkit provides standard measures for genome and population studies
11. K-State plant pathologists develop online teaching modules used globally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... have developed a novel and versatile modeling strategy to ... new materials as well as for studying polyelectrolytes, including ... to model much larger and more complex polyelectrolyte systems, ... Li, lead author of a paper on the work ... Materials Science and Engineering. "This is a big step ...
(Date:8/20/2014)... a John and Rebecca Moores Professor of Biology and Biochemistry ... in the International Society for the Study of the Origin ... members two from the U.S., one from France and ... are elected every three years, and 36 have been named ... 20 countries, the ISSOL includes researchers from disciplines as varied ...
(Date:8/20/2014)... LAKE CITY Researchers at Huntsman Cancer Institute (HCI) at ... forms of the gene that encodes BCR-ABL, the unregulated ... According to the American Cancer Society, nearly 6,000 new ... Drugs already in use, called tyrosine kinase inhibitors (TKIs), ... They do not cure CML but control it in ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2UH professor named fellow by International Astrobiology Society 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... for Free-Electron Laser Science have devised a novel way to boil ... concept, which has not yet been demonstrated in practice, could heat ... Celsius in just half a picosecond (a trillionth of a second). ... one picosecond is to a second what one second is to ...
... like Alzheimer,s, Parkinson,s and Creutzfeldt-Jakob disease. But amyloid ... the development of new composite materials for the ... even make objects invisible. Researchers from Chalmers ... about amyloid in an article published in the ...
... Caribou in southern and eastern Canada may disappear from most ... takes the toll on their habitat that scientists predict in ... Nature Climate Change . Scientists looked at reservoirs of ... to stable habitats. They found that caribou populations in the ...
Cached Biology News:Ultrafast heating of water -- This pot boils faster than you can watch it 2Ultrafast heating of water -- This pot boils faster than you can watch it 3Alzheimer substance may be the nanomaterial of tomorrow 2Climate change threatens genetic diversity, future of world's caribou 2
(Date:8/20/2014)... The 6th Annual Arrowhead Personalized ... October 29-30 in San Francisco, CA. This year’s conference ... researchers and clinicians focused on addressing and solving the ... the twelve years since the sequencing of the human ... with pharmacogenetic information in the label and molecular diagnostics ...
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
(Date:8/19/2014)... Piscataway, NJ (PRWEB) August 20, 2014 ... engineering and regenerative medicine is an inadequate vascular ... engineered constructs and decellularized tissues is critical for ... Researchers have attempted to mitigate deficiencies in vascularization ... including adding scaffold bioactivity, optimizing scaffold design and ...
(Date:8/19/2014)... , Aug. 19, 2014 A Geisinger ... been nominated for a Centers for Disease Control and ... a major public health concern. Joseph ... is one of a team of researchers nominated for ... C. Shepard Science Award for Data Methods and Study ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... Increase 53% and 52% Respectively ... ... CLRT ), a premier technology and services resource for,pathologists, oncologists and ... year ended December 31, 2007.,Revenue from continuing operations was $12.4 million ...
... ... presentations, SOUTH SAN FRANCISCO, Calif., March 31 ,Exelixis, Inc. ... company,s investigational compounds XL647, XL184, XL765 and,XL880 will be presented at the ... from May 30 to June 3, 2008 in,Chicago, Illinois. The clinical trial ...
... Medarex, Inc.,(Nasdaq: MEDX ) today announced ... undisclosed amount from its licensing partner, Novo Nordisk ... of an Investigational New Drug,application by Novo Nordisk ... Medarex,s UltiMAb(R) technology. Medarex may receive future,milestone payments ...
Cached Biology Technology:Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 2Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 3Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 4Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 5Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 6Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 7Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 8Clarient Announces Fourth Quarter and Year-End 2007 Financial Results 9Seven Abstracts Featuring Exelixis Compounds Accepted for Presentation at 2008 ASCO Annual Meeting 2Medarex to Receive Milestone Payment from Novo Nordisk 2
... (RNase III) from E. coli is an ... to dsRNA fragments that have 2-base, 3'-overhangs. ... dsRNA fragments of 12-15 bp. RNase ... canonical ribonucleotides as well as DuraScript™ RNA, ...
...
...
... to CRF The antibody ... CRF sequence that it was ... are found in the paraventricular ... in colchicine treated 4% FA ...
Biology Products: