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JCI online early table of contents: Jan. 4, 2011
Date:1/4/2011

d Xue Huang, has now found that downregulating expression of the protein A20 on immune cells known as DCs enhances their ability to induce both mucosal and systemic immune responses to HIV proteins in mice. The authors suggest that although further preclinical studies are necessary, these data might help researchers develop an efficient HIV vaccination strategy.

TITLE: Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells

AUTHOR CONTACT:
Si-Yi Chen
University of Southern California, Los Angeles, California, USA.
Phone: 323.442.7727; Fax: 323.442.7729; E-mail: siyichen@usc.edu

Xue F. Huang
University of Southern California, Los Angeles, California, USA.
Phone: 323.442.7727; Fax: 323.442.7729; E-mail: xuefhuan@usc.edu.

View this article at: http://www.jci.org/articles/view/42656?key=ee478abd222bbf3fdcc3


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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