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JCI online early table of contents: Jan. 4, 2011
Date:1/4/2011

ree of the fungi linked to the majority of cases of systemic fungal infection in North America. The authors therefore suggest that vaccines designed to prevent systemic fungal infections in humans should be designed to induce Th17 cells.

TITLE: Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice

AUTHOR CONTACT:
Marcel Wthrich
University of Wisconsin, Madison, Wisconsin, USA.
Phone: 608.262.7703; Fax: 608.262.8418; E-mail: mwuethri@wisc.edu.

View this article at: http://www.jci.org/articles/view/43984?key=22b1a80a5663dc4420b2


IMMUNOLOGY: TRACking immune deficiency

Impaired functioning of the immune system can be an inherited condition. Mutations in any one of a large number of genes involved in immune cell function can cause such disorders. A team of researchers, led by Eammon Maher, at the University of Birmingham School of Medicine, United Kingdom, has now identified another gene that can be added to the list: TRAC. Individuals with mutations in this gene exhibited autoimmunity (a condition in which the immune system turns on cells and/or tissues of the patient's own body) and increased susceptibility to certain infections. However, they surprisingly were protected from many infections, indicting that the TRAC mutations lead to only a partial immunodeficiency.

TITLE: Mutation in the TCR-alpha subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCR-alpha-beta+ T cells

AUTHOR CONTACT:
Eamonn R. Maher
University of Birmingham School of Medicine, Birmingham, United Kingdom.
Phone: 44.121.627.2741; Fax: 44.121.414.2538; E-mail: e.r.maher@bham.ac.uk.

View this article at:

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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