TITLE: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation
Charles N. Serhan
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.525.5001; Fax: 617.525.5017; E-mail: email@example.com.
View this article at: http://www.jci.org/articles/view/42545?key=4069526bb3558baf9ccf
VACCINE DESIGN: How to keep fungi at bay
Infections with fungi that initially start at one site (often the lung) and then spread to other organs in the body are known as systemic fungal infections. As rates of such infections have increased dramatically in recent years, researchers are keen on developing vaccines against these invasive microbes. A team of researchers, led by Marcel Wthrich, at the University of Wisconsin, Madison, has now generated data in mice that provide insight into the type of immune response that such vaccines need to generate.
In North America, the three main fungi that cause systemic fungal infections are Coccidioides posadasii, Histoplasma capsulatum, and Blastomyces dermatitidis. In the study, immune cells known as Th17 cells were found to be sufficient for vaccine-induced protection against lethal lung infection with Blastomyces dermatitidis in mice. Further, vaccine-induced Th17 cells were necessary and sufficient to protect mice against all th
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Journal of Clinical Investigation