EDITOR'S PICK: Going bald without hair follicle progenitors
Androgenetic alopecia (AGA) is a frequent form of hair loss in both men and women. However, it is more common in men, in whom it is also known as male-pattern baldness. Through the analysis of bald and non-bald scalp samples from men with AGA, a team of researchers, led by George Cotsarelis, at the University of Pennsylvania School of Medicine, Philadelphia, has gained new insight into the underlying causes of AGA. Specifically, the data indicate that a defect in the conversion of hair follicle stem cells to progenitor cells has an important role in AGA. The authors therefore suggest that further studies defining the signals responsible for the transition of stem cells to progenitor cells could provide new therapeutic targets for the treatment of AGA.
TITLE: Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
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View this article at: http://www.jci.org/articles/view/44478?key=0a1481860c0b098075c7
EDITOR'S PICK: Dampening inflammation with aspirin
Inflammation is a protective response to invading microbes and tissue damage. Upon microbe clearance from the body or completion of wound healing, the inflammatory response must be dampened down. One set of molecules known to play a role in resolving the inflammatory response is the E-series resolvins. While analyzing the blood of several individuals to investigate the pathway by which E-series resolvins are generated, Charles Serhan and colleagues, at Harvar
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Journal of Clinical Investigation