Navigation Links
JCI online early table of contents: Jan. 19, 2009
Date:1/19/2009

EDITOR'S PICK: Fetal heath affected by mother's diet

In the United States, there has been a recent dramatic rise in the number of children classified as obese and diagnosed with obesity-related diseases, such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). One factor thought to contribute to this rise is obesity of the mother during pregnancy. However, a team of researchers, at Oregon Health and Science University, Beaverton, and the University of Colorado School of Medicine, Aurora, have found the offspring of both lean and obese nonhuman primate mothers chronically consuming a high-fat diet exhibited an increased risk of developing NAFLD. Importantly, if mothers fed a high-fat diet were reverted to a low-fat diet during a subsequent pregnancy, this second offspring exhibited fewer signs of NAFLD. The team, led by Kevin Grove and Jacob Friedman, therefore suggests that a developing fetus is highly susceptible to maternal consumption of excess fat, whether or not the mother is obese, and that a healthy maternal diet is most important for the obesity-related health of a developing fetus.

TITLE: Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

AUTHOR CONTACT:
Kevin L. Grove
Oregon Health and Science University, Beaverton, Oregon, USA.
Phone: (503) 690-5380; Fax: (503) 690-5384; E-mail: grovek@ohsu.edu.

Jacob E. Friedman,
University of Colorado School of Medicine, Aurora, Colorado, USA.
Phone: (303) 724-3983; Fax: (303) 724-3920; E-mail: jed.friedman@ucdenver.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32661


ONCOLOGY: Antibodies targeting the protein Pim-1 inhibit cancer cell growth

In a number of human cancers, including prosta
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. New online report on massive jellyfish swarms released
2. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
3. Smithsonian puts tropical eastern Pacific shore fishes online
4. Smithsonian puts tropical Eastern-Pacific shore fishes online
5. Latin American Science Initiative Puts Tropical Rainforest Diversity Online
6. Personalized medicine: Innovative online journal leads the way
7. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
8. American Physical Society announces Physics, a new, free, online publication
9. Yale Environment 360 magazine launches online
10. Nonlinear ecosystem response points to environmental solutions
11. UF to auction naming rights for new butterfly species online
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 22, 2014 ... announced the addition of the  "Biometrics ... to their offering.       ... a technology that helps in the ... physical or behavioral features. It involves ...
(Date:8/22/2014)... Thomson Reuters , a leading source of information for ... University of California, Riverside in its 2014 list of ... times." , To generate the list, the company analyzed ... whose published work has had enormous impact. , The ... individuals who published the greatest number of highly cited ...
(Date:8/22/2014)... CA Research presented at the 29th Annual ... developed by Hera Therapeutics Inc. combats three types ... 70 percent of all cervical cancer. , When ... blocked the replication of HPV-16, HPV-18 and HPV-11 ... Thomas Broker, Ph.D., who presented the findings at ...
Breaking Biology News(10 mins):Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 2Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 35 UC Riverside scientists among world's most influential scientific minds 2
... is available in Polish . A ... mouse embryos can repair damaged brain circuitry and partially normalize ... obese due to a genetic deficiency. This proof-of-principle discovery represents ... which researchers hope might one day be used to repair ...
... National Taiwan University researchers have successfully manipulated the life span ... remove and restore protein functions related to yeast aging. ... in yeast acts like a life span clock: It is ... age. In a report in the September 16 edition ...
... and the University of Geneva have discovered a genetic mechanism ... genes play only a secondary role. The research published in ... mechanism is found in a DNA sequence that was thought, ... enhancers which, when combined with one another, modulate the activity ...
Cached Biology News:Metabolic defects in mice corrected with transplanted embryonic neurons 2Hopkins scientists turn on fountain of youth in yeast 2Finger (mal)formation reveals surprise function of desert DNA 2
(Date:8/22/2014)... August 22, 2014 Today the Academy of ... United States Court of Appeals for the D.C. Circuit challenging ... published in the Federal Register on June 25, 2014. ... contrary to the text and intent of the FAA Modernization ... Congress’ specific prohibition on any new rules or regulations regarding ...
(Date:8/22/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... 30, 2014.  Biorem,s complete 2014 second quarter financial statements and MD&A have ... June 30, , Six-months ended June 30, ( ... 2013 , 2014 , 2013 Revenue , ... 9,195 Gross profit , 56 , 1,485 ...
(Date:8/22/2014)... University of Surrey have discovered how the receptors responsible ... genes. , The new study, published today in ... activity in turn regulates the cycle of all cells ... that the local biological clock and its control are ... clock in bladder physiology and ageing. , ...
(Date:8/22/2014)... a study published today (August 22nd), in the ... the Champalimaud Neuroscience Programme establish the effect of ... of advanced genetic and optical techniques., "Serotonin is ... a wide range of brain functions, from the ... of complex emotional behaviours, This neurotransmitter is also ...
Breaking Biology Technology:AMA Files Petition for Review of FAA’s Interpretive Rule 2Biorem Reports 2014 Second Quarter Results 2Biorem Reports 2014 Second Quarter Results 3Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research 2From happiness to pain: Understanding serotonin's function 2
... Wis. -- Gov. Jim Doyle says taxpayers will ... total of nearly $80 million over the lifetime of ... and services, including a number of technology areas. , ... Accountability, Consolidation, and Efficiency (ACE) Initiative to ensure ...
... of Milwaukee is one of six first-year college students from ... Online's "Project Freshman," a new documentary series that will be ... Friday, Sept. 23. New episodes will air every Thursday. The ... were given digital video cameras and were trained in their ...
... -- The Wisconsin Technology Council has teamed with PropertyDrive, ... database of commercial real estate on the Tech Council ... on the site's Resource Center, Commercial Property Search. , ... locate or expand in Wisconsin the ability to search ...
Cached Biology Technology:
Rabbit polyclonal to Flagellin ( Abpromise for all tested applications). Antigen: Synthetic peptide from the flagellin C terminal domain of Burkholderia pseudomallei....
This application changes sensitive keywords in an FCS file to remove patient information. It was contributed by Dr. David Miller....
... Killer Cell Receptor-P1, clone 1C10 ... Hybridoma produced by the ... mice immunized (BALB/c X C57BL/6)F1 ... and mouse myeloma cellline. ...
Phospho-SEK1/MKK4 (Thr261) Antibody...
Biology Products: