Navigation Links
JCI online ahead of print table of contents for May 1, 2014
Date:5/1/2014

Balancing protein turnover in the heart

Alterations in the ubiquitin proteasome system (UPS), which tags proteins for degradation, underlies some cardiomyopathies and age-related cardiac dysfunction. In the heart, the UPS is essential for the precise balance between cardiomyocyte atrophy and hypertrophy. In skeletal muscle, the E3 ubiquitin ligase atrogin-1 promotes atrophy by targeting hypertrophy-associated proteins for degradation; however, a role for atrogin-1 in cardiac proteostasis is not clear. In this issue of the Journal of Clinical Investigation, Marco Sandri, Marco Mongillo and colleagues at the Venetian Institute of Molecular Medicine investigated cardiac homeostasis in atrogin-1-deficient mice. Aged animals lacking atrogin-1 exhibited enlarged and abnormally shaped hearts, thickened left ventricular walls, increased fibrosis and apoptosis, and reduced function. Loss of atrogin-1 led to increased ER stress and upregulation of genes involved in the unfolded protein response (UPR). Moreover, autophagy, which is inhibited by the UPR in skeletal muscle, was also repressed in cardiac tissue of atrogin-1 null animals, suggesting that atrogin-1 may target autophagy-related proteins for degradation. Evaluation of cardiac protein turnover in atrogin-1-deficient animals revealed reduced turnover of lysosomal targets, including the endosomal sorting complex III protein CHMP2B. Silencing CHMP2B in atrogin-1 null mice restored markers of autophagy and reduced apoptosis in the heart. These results indicated that UPS-regulated autophagy in the protein turnover necessary for cardiomyocyte health.

TITLE: Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

AUTHOR CONTACT: Marco Sandri
Venetian Institute of Molecular Medicine, Padova, UNK, ITA
Phone: +39 049 7923258; Fax: +39 049 7923250; E-mail: marco.sandri@unipd.it'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. JCI online ahead of print table of contents for April 17, 2014
2. JCI online ahead of print table of contents for April 8, 2014
3. JCI online ahead of print table of contents for March 25, 2014
4. Online tool aids clinicians efforts to treat injured workers
5. GreatWineProducts.com Opens Its Online Store for Holiday Shopping: Personal and Corporate Gifts Available
6. Missouri Botanical Garden aims to improve access to digital texts through online gaming
7. 2 online science video pioneers combine to form new iBiology.org
8. Geosphere, GSAs dynamic online-only journal posts 9 new articles in Sept.
9. Online citizen scientists: Classify plankton images
10. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
11. Reproductive BioMedicine Online publishes study on assisted reproduction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group ... NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one ... feedback on their experience with the Wocket in multiple scenarios ... CVS, Whole Foods and other retailers, making both debit and ... Tuttle also says, "If the company meets their plans ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ... "India Sensors Market Forecast and Opportunities 2020" ... market is projected to grow at a CAGR ... automotive, industrial and healthcare sectors are the key ... addition, adoption of MEMS technology in sensors is ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... from the University of Georgia College of Veterinary ... could open new avenues for treating Ichthyophthirius multifiliis, ... commonly attacks freshwater fish. With the aid ... two apparently symbiotic intracellular bacteria: Bacteroides, which ...
... Duke University Medical Center researchers have figured out how ... better able to resist radiation therapy. And using a drug ... cells, they were able to kill many more glioma cells ... builds off earlier research which showed that cancer stem cells ...
... is good for you, at least if you are a ... Oncology Center have shown that in healthy cells, a bundled ... storehouse, in its proper place. Understanding this cap,s influence on ... to the diagnosis and treatment of diseases such as cancer, ...
Cached Biology News:UGA researchers lead team in discovery involving devastating freshwater fish parasite, 'Ich' 2UGA researchers lead team in discovery involving devastating freshwater fish parasite, 'Ich' 3Discovery makes brain tumor cells more responsive to radiation 2A cell's 'cap' of bundled fibers could yield clues to disease 2
(Date:4/2/2015)... (PRWEB) April 02, 2015 One ... is to avoid false negative results. MultiGEN Diagnostics, ... Choice Laboratory Services, LLC (PCLS), has developed a ... eliminates false negatives, while at the same time ... “This unique combination is expected to improve the ...
(Date:4/1/2015)... “Science can be fun” was a key message, as ... a Girl to Engineering Day” at the University of Texas ... technology were presented by the UT Austin SPIE Student Chapter, ... $60,000 in International Year of Light activity grants ... . The IYL grants are in addition to education outreach ...
(Date:4/1/2015)... 01, 2015 Shimadzu Corporation announced ... Unified Chromatography system (Nexera UC) received the Pittcon ... on Analytical Chemistry and Applied Spectroscopy (Pittcon) held ... 12th. , The Pittcon Editors’ Awards recognize ... the first time based on votes by the ...
(Date:4/1/2015)... 1, 2015  VLP Therapeutics, LLC. ("VLP"), a ... research and development of therapeutic and preventative vaccines and ... proprietary vaccine technology, today announced that it has entered into ... at Nagasaki University in ... research and development of dengue vaccine candidates. ...
Breaking Biology Technology:MultiGEN Diagnostics, LLC Announces the Use of IC-Code™ Technology to Eliminate False Negatives in Molecular Diagnosis. 2Fun, wonder, importance of light are messages in SPIE Student Chapter IYL2015 events 2Fun, wonder, importance of light are messages in SPIE Student Chapter IYL2015 events 3Shimadzu Nexera UC Recognized at Pittcon 2015 with Editors’ Gold Award 2VLP Therapeutics Enters Collaboration with Institute of Tropical Medicine, Nagasaki University 2VLP Therapeutics Enters Collaboration with Institute of Tropical Medicine, Nagasaki University 3
... 2008, SAN DIEGO, May 12 Neurocrine Biosciences,Inc. ... will,present at the Citi Investment Research Global Health Care ... place Thursday, May 22,2008 at 3:00 p.m. Eastern Time ... simultaneously webcast and may be accessed on the,Company,s website ...
... MedApps announced today, that,it has been selected as ... as,part of Dell,s 2008 Global Small Business Excellence ... Health Monitoring System helps connect,people afflicted with chronic ... COPD, with their healthcare providers. This is,accomplished by ...
... Care, ST. LOUIS, May 12 Veran ... $4.75M in venture capital and private,financing to drive ... biopsy and ablation of cancer. St. Louis-based Prolog ... Capital Partners and existing private,investors. Veran also relocated ...
Cached Biology Technology:MedApps Selected as Dell-NFIB 2008 Business Excellence Award Finalist 2MedApps Selected as Dell-NFIB 2008 Business Excellence Award Finalist 3Veran Medical Technologies Secures $4.75M in First Institutional Funding 2
Chicken Aortic Smooth Muscle Cells (CAOSMC) (>500,000 cells)...
... Start Taq Monoclonal Antibody ... the onset of thermal ... and primer-dimer formation. When ... the antibody is quickly ...
... brings together UV irradiation and antimicrobial stainless ... PCR contamination! Quickly inactivate DNA between ... clean environment with antimicrobial coated stainless steel ... minutes with built-in 30-minute timer ...
... and easy to use Ascent ... all members of the Ascent ... a clear and easy-to-follow approach ... user-friendly and highly sophisticated data ...
Biology Products: