Navigation Links
JCI online ahead of print table of contents for April 8, 2014
Date:4/9/2014

Visualizing calcium dynamics in the kidney

In this issue of the Journal of Clinical Investigation, Janos Peti-Peterdi and colleagues at the University of Southern California used multiphoton microscopy (MPM) to directly visualize podocyte calcium dynamics within the intact kidneys of live mice. A robust calcium wave was generated in response to glomerular injury and this signal spread throughout cells. Mice lacking the P2Y2 purinergic receptor or treated with inhibitors of calcium signaling prevented propagation of a calcium wave. Furthermore, increased calcium signaling correlated with loss of glomerular filter integrity. Together this results suggest that calcium signaling mediates pathogenic responses to injury in the kidney.

TITLE: Intravital imaging of podocyte calcium in glomerular injury and disease

AUTHOR CONTACT: Janos Peti-Peterdi University of Southern California, Los Angeles, CA, USA Phone: 323-442-4337; E-mail: petipete@usc.edu

View this article at: http://www.jci.org/articles/view/71702


Characterization of an asplenic patient with disorder of sexual development

Mutations with in the gene encoding the transcription factor steroidogenic factor 1 (SF-1) are associated with disorders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adrenocortical deficiency. In this issue of the Journal of Clinical Investigation, David Zangen and colleagues at Hadassah Hebrew University Medical Centre identified a recessive mutation within SF1 that resulted in both severe 46,XY-DSD and asplenia in a pediatric patient. Interestingly, this particular SFI mutation decreased transactivation of TLX1, a transcription factor essential for murine spleen development. Additionally, the <
'/>"/>

Contact: Corinne Wiliams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A new application allows online statistical analysis of gene-expression data
2. Putting plants online: 4 leading botanical gardens to create first online catalog of all plants
3. Botanical institutions announce plans to create first online World Flora
4. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
5. MindSpec launches online Autism Reading Room
6. A new type of data papers designed to publish online interactive keys identifying biodiversity
7. Do dolphins think nonlinearly?
8. A charismatic new lacewing from Malaysia discovered online by chance
9. Houston Clean Air Network offering real-time online ozone report
10. GEOLOGY adds 30 new articles online
11. GEOLOGY speeding top science to online platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... for evaluation of suspected genetic conditions, whole-exome sequencing ... including detection of a number of rare genetic ... to a study appearing in JAMA . ... the American Society of Human Genetics annual meeting. ... regions of thousands of genes simultaneously using next-generation ...
(Date:10/17/2014)... from the University of Copenhagen have shown for the ... lungs of Cystic fibrosis patients, giving them the opportunity ... in chronic infections. , The study also discovered the ... (CF) patients was halted or slowed down by the ... all the oxygen and helped "suffocate" the bacteria, forcing ...
(Date:10/16/2014)... managers have a new synthesis of recent research findings ... forests in the two states. , The Ecology ... and Washington: A Synthesis of the Relevant Biophysical Science ... report published by the U.S. Forest Service,s Pacific Northwest ... from managers for a synthesis of the large body ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2
... concept of "place" is increasingly being considered in the ... new resource that can help them recognize and respond ... their lives. Place-Based Conservation: Perspectives from the ... Northwest Research Station,s Linda Kruger, can help managers take ...
... in the blood often jump into action by multiplying ... off illness. But repeated infections and inflammation can deplete ... serious blood conditions such as cancer. Now, a team ... of Technology (Caltech) has found that, in mouse models, ...
... have developed a new method for delivering molecules into ... surface. The technique could find applications in drug delivery, ... a technique used to deliver molecules into cells ... caused by exposing them to electric pulses is ...
Cached Biology News:Keeping stem cells strong 2Single-cell transfection tool enables added control for biological studies 2
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is seeking ... stem cells for dogs with osteoarthritis. Dr. McCarthy has ... clinical stem cell therapy for 7 years. The ultimate ... single injection of donor stem cells into one or ... inflammation in the treated joints. , Candidates for ...
(Date:10/19/2014)... 2014 The Asia-Pacific Bromine Market ... Asia-Pacific with analysis and forecast of revenue. , ... Bromine Market report, to get an idea of ... glimpse of the segmentation in the Asia-Pacific bromine ... figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems report defines ... forecast of revenue. The Orthopedic braces and support systems market ... by 2018, at a developing CAGR of 4.4% from 2013 ... Orthopedic braces and support systems market, to get an idea ... of the segmentation of orthopedic braces and support systems market ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... CAMBRIDGE, Mass., Aug. 25 Peptimmune, Inc., ... a clinical trial to evaluate the safety, tolerability, pharmacokinetics, ... Multiple Sclerosis (SP-MS). PI-2301 is a novel peptide ... autoimmune diseases. , , The Phase ...
... CITY, Aug. 25 /PRNewswire-FirstCall/ - Medicago Inc. (TSX-V: ... effective and affordable vaccines based on proprietary manufacturing ... it has received clearance from Health Canada to ... its H5N1 Avian Influenza vaccine ("H5N1 vaccine"). Enrollment ...
... , SAN MATEO, Calif., Aug. 25 ... on developing and commercializing novel pain management therapies, today announced the ... a director and Audit Committee chairman, effective August 20, 2009. Mr. ... company focused on exploiting a novel, Nobel Prize winning method of ...
Cached Biology Technology:Peptimmune Completes Phase Ib Study of PI-2301 in Multiple Sclerosis Patients, and Presentation at ECTRIMS 2009 2Peptimmune Completes Phase Ib Study of PI-2301 in Multiple Sclerosis Patients, and Presentation at ECTRIMS 2009 3Medicago receives regulatory approval to begin human clinical testing with its avian flu pandemic vaccine 2Medicago receives regulatory approval to begin human clinical testing with its avian flu pandemic vaccine 3NeurogesX Appoints New Board Director and Audit Committee Chairman 2NeurogesX Appoints New Board Director and Audit Committee Chairman 3NeurogesX Appoints New Board Director and Audit Committee Chairman 4NeurogesX Appoints New Board Director and Audit Committee Chairman 5
... The 2.0 network client/server version of Freezerworks ... workflow in high-volume labs and facilitates the sharing ... to share sample information. ... PowerPC (100MHz, PPC 601); 13 in monitor with ...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
Mixing speed from 750-3200RPM, small vortexing orbit of1.0mm...
... ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside C 14 H 15 ... ,M.W.= 408.63 ,Assay: Greater than ... DMF) ,Biological Activity: Blue color with ... Agrees with theoretical values ,Thin Layer ...
Biology Products: