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JCI online ahead of print table of contents for April 8, 2014
Date:4/9/2014

Visualizing calcium dynamics in the kidney

In this issue of the Journal of Clinical Investigation, Janos Peti-Peterdi and colleagues at the University of Southern California used multiphoton microscopy (MPM) to directly visualize podocyte calcium dynamics within the intact kidneys of live mice. A robust calcium wave was generated in response to glomerular injury and this signal spread throughout cells. Mice lacking the P2Y2 purinergic receptor or treated with inhibitors of calcium signaling prevented propagation of a calcium wave. Furthermore, increased calcium signaling correlated with loss of glomerular filter integrity. Together this results suggest that calcium signaling mediates pathogenic responses to injury in the kidney.

TITLE: Intravital imaging of podocyte calcium in glomerular injury and disease

AUTHOR CONTACT: Janos Peti-Peterdi University of Southern California, Los Angeles, CA, USA Phone: 323-442-4337; E-mail: petipete@usc.edu

View this article at: http://www.jci.org/articles/view/71702


Characterization of an asplenic patient with disorder of sexual development

Mutations with in the gene encoding the transcription factor steroidogenic factor 1 (SF-1) are associated with disorders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adrenocortical deficiency. In this issue of the Journal of Clinical Investigation, David Zangen and colleagues at Hadassah Hebrew University Medical Centre identified a recessive mutation within SF1 that resulted in both severe 46,XY-DSD and asplenia in a pediatric patient. Interestingly, this particular SFI mutation decreased transactivation of TLX1, a transcription factor essential for murine spleen development. Additionally, the <
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Contact: Corinne Wiliams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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