Navigation Links
JCI online ahead of print table of contents for April 8, 2014
Date:4/9/2014

Visualizing calcium dynamics in the kidney

In this issue of the Journal of Clinical Investigation, Janos Peti-Peterdi and colleagues at the University of Southern California used multiphoton microscopy (MPM) to directly visualize podocyte calcium dynamics within the intact kidneys of live mice. A robust calcium wave was generated in response to glomerular injury and this signal spread throughout cells. Mice lacking the P2Y2 purinergic receptor or treated with inhibitors of calcium signaling prevented propagation of a calcium wave. Furthermore, increased calcium signaling correlated with loss of glomerular filter integrity. Together this results suggest that calcium signaling mediates pathogenic responses to injury in the kidney.

TITLE: Intravital imaging of podocyte calcium in glomerular injury and disease

AUTHOR CONTACT: Janos Peti-Peterdi University of Southern California, Los Angeles, CA, USA Phone: 323-442-4337; E-mail: petipete@usc.edu

View this article at: http://www.jci.org/articles/view/71702


Characterization of an asplenic patient with disorder of sexual development

Mutations with in the gene encoding the transcription factor steroidogenic factor 1 (SF-1) are associated with disorders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adrenocortical deficiency. In this issue of the Journal of Clinical Investigation, David Zangen and colleagues at Hadassah Hebrew University Medical Centre identified a recessive mutation within SF1 that resulted in both severe 46,XY-DSD and asplenia in a pediatric patient. Interestingly, this particular SFI mutation decreased transactivation of TLX1, a transcription factor essential for murine spleen development. Additionally, the SF1 mutation decreased expression of steroidogenic genes, without affecting synergistic SF-1 and sex-determining region Y (SRY) coactivation of the testis development gene SOX9. This study indicates that SF-1 is required for both steroidogenesis and spleen development in humans.

TITLE: Testicular differentiation factor SF-1 is required for human spleen development

AUTHOR CONTACT: David Zangen Hadassah Hebrew University Medical Centre, Jerusalem, ISR Phone: 972.2.5844430; E-mail: zangend@hadassah.org.il

View this article at: http://www.jci.org/articles/view/73186


ENDOCRINOLOGY

TITLE: Vascular rarefaction mediates whitening of brown fat in obesity

AUTHOR CONTACT: Kenneth Walsh Boston University School of Medicine, Boston, MA, USA Phone: 617-414-2392; Fax: 617-414-2391; E-mail: kxwalsh@bu.edu

View this article at: http://www.jci.org/articles/view/71643

TITLE: Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

AUTHOR CONTACT: Antonio Zorzano Institute for Research in Biomedicine (IRB Barcelona), Barcelona, ESP Phone: 34-93-403-7197;; E-mail: antonio.zorzano@irbbarcelona.org

View this article at: http://www.jci.org/articles/view/72327

IMMUNOLOGY

TITLE: CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

AUTHOR CONTACT: Nathan Karin Department of Immunology, Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, ISR Phone: 972.4.8295232; E-mail: nkarin10@gmail.com

View this article at: http://www.jci.org/articles/view/71951

ONCOLOGY

TITLE: Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC

AUTHOR CONTACT: Jin Chen Vanderbilt University School of Medicine, Nashville, TN, USA Phone: 615-343-3819; Fax: 615-343-8648; E-mail: jin.chen@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/72522

HEPATOLOGY

TITLE: Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway

AUTHOR CONTACT: Anthony N. Hollenberg Beth Israel Medical Center, Harvard Medical School, Boston, MA, USA Phone: 617.735.3268; E-mail: thollenb@bidmc.harvard.edu

View this article at: http://www.jci.org/articles/view/73419


'/>"/>

Contact: Corinne Wiliams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related biology news :

1. A new application allows online statistical analysis of gene-expression data
2. Putting plants online: 4 leading botanical gardens to create first online catalog of all plants
3. Botanical institutions announce plans to create first online World Flora
4. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
5. MindSpec launches online Autism Reading Room
6. A new type of data papers designed to publish online interactive keys identifying biodiversity
7. Do dolphins think nonlinearly?
8. A charismatic new lacewing from Malaysia discovered online by chance
9. Houston Clean Air Network offering real-time online ozone report
10. GEOLOGY adds 30 new articles online
11. GEOLOGY speeding top science to online platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
(Date:1/28/2016)... Synaptics (NASDAQ: SYNA ), a leading developer of human interface ... 31, 2015. --> --> ... percent compared to the comparable quarter last year to $470.5 million. ... million, or $0.93 per diluted share. --> ... of fiscal 2016 grew 9 percent over the prior year period ...
(Date:1/22/2016)... , January 22, 2016 /PRNewswire/ ... announced the addition of the  "Global ... their offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... Texas (PRWEB) , ... February 10, 2016 , ... ... centers across three states, announced today the promotion of two long-standing principal investigators ... Chief of Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, a ...
(Date:2/10/2016)... ... ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their new high-speed ... Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS Expo on ... diode standard packages feature a TO-46 metal can with active areas of 1.0mm and ...
(Date:2/10/2016)... ... 10, 2016 , ... PatientCrossroads announces that the ... online PatientCrossroads platform, has exceeded both its one-year and overall recruitment goals since ... which seeks to advance understanding of the hereditary risks for certain kinds of ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... has announced a new agreement with Singapore-based Global Stem Cells Network (GSCN) and ... Philippines, Thailand and Singapore in the latest adipose and bone marrow therapies. ...
Breaking Biology Technology: