Navigation Links
JCI early table of contents for May 24, 2013
Date:5/24/2013

h

Dysregulated gene expression is a feature of most cancers. In this issue of the Journal of Clinical Investigation, Gal Markel and colleagues at Chaim Sheba Medical Center in Ramat-Gan, Israel, demonstrated that expression of the RNA editing enzyme ADAR1 is frequently reduced in melanoma that was linked to the development of metastases. Loss of ADAR1 enhanced the growth and tumor-forming ability of the melanoma cells. Markel and colleagues found that ADAR1 normally regulates the expression of microRNAs, molecules that help to control the expression of specific genes. In turn, microRNAs also control the expression of ADAR1. These studies demonstrate that loss of an RNA editing enzyme contributes to the development of a more aggressive, metastatic form of melanoma.

TITLE:
MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

AUTHOR CONTACT:
Gal Markel
Chaim Sheba Medical Center, Ramat-Gan, ISR
Phone: 972-3-5304591; E-mail: markel@post.tau.ac.il

View this article at: http://www.jci.org/articles/view/62980?key=96ee313210f0982ab94b


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. Mid-Atlantic suburbs can expect an early spring thanks to the heat of the big city
3. An early spring drives butterfly population declines
4. Hazy shades of life on early Earth
5. American Society of Plant Biologists honors early career women scientists
6. Early warning system for seizures could cut false alarms
7. A new gene thought to be the cause in early-onset forms of Alzheimers disease
8. Promising developments in early diagnosis and treatment of mesothelioma
9. Early detection techniques offer hope for improved outcomes in lung cancer patients
10. New study links air pollution and early death in the UK
11. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... Most cancer deaths occur because of metastasis, yet ... has been slow. , "It,s been particularly challenging ... Taran Gujral, research fellow in systems biology at ... aren,t detected until after they,ve already metastasized." , ... culprit that should help researchers better understand how ...
(Date:11/5/2014)... show great diversity in their ability to identify scents ... differ in their perceptual evaluation of odors, with women ... , Sex differences in olfactory detection may play ... connected to one,s perception of smell, which is naturally ... superiority has been suggested to be cognitive or emotional, ...
(Date:11/4/2014)... only marketing directed at children on the interior ... that the majority of black, middle-income and rural ... , Authored by Arizona State University researcher Punam ... first to examine the use of child-directed marketing ... restaurants and its relationship to demographics. It adds ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
... announced today that Oligonol, manufactured by Amino Up Chemical ... of the SupplySide West 2011 Scientific Excellent Award. The ... October 12, 2011 in Las Vegas at The Venetian ... with new ingredients or technologies, as well as those ...
... an interview with a researcher, please contact the Communications and ... tip. For more information on ORNL and its research and ... If you have a general media-related question or comment, you ... -- Green checkered flag . . . ...
... 10th-14th, more than a hundred scientists from twenty-four countries ... and reservoirs, including what can be done to keep ... competing demands. The meeting is being organized by the ... of limnologists, ecologists, information technology experts, and engineers who ...
Cached Biology News:Oligonol receives Supplyside West 2011 scientific Excellence Award 2Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 2Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 3Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 4Fate of lakes focus of international meeting in Sunapee, N.H. 2
(Date:11/21/2014)... 2014 /CNW/ - Aequus Pharmaceuticals Inc. (the "Company" ... has closed a brokered private placement offering (the ... million.  Cormark Securities Inc. and Clarus Securities Inc. ... for a syndicate of agents that also included ... the "Agents"). Concurrently with the Brokered Offering, the ...
(Date:11/21/2014)... , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... nine month periods ended September 30, 2014.  Biorem,s complete 2014 third ... www.sedar.com ). Financial Summary:Three-months ended September 30, ... per share data) , 2014 , 2013 ... 2,282 , 5,281 , 6,715 , ...
(Date:11/18/2014)... 2014 RPS Diagnostics (RPS®) – ... today announces its third annual partnership of the ... Smart About Antibiotics Week from November 17-23. , ... campaign designed to highlight the coordinated efforts of ... and for-profit partners to provide education about the ...
(Date:11/18/2014)... 2014 pH measurement and control is ... pharmaceutical, chemical, and food and beverage industries. But what ... how do pH sensors work? METTLER TOLEDO has produced ... process industries with these questions and more. , METTLER ... the process industries. The actual sensor, the pH electrode, ...
Breaking Biology Technology:Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2
... on the basis ... Mass., Sept. 10 Hyaluron Contract,Manufacturing (HCM), a leading ... and biotechnology industries, announced,today that it has been selected ... Award. HCM is one of five companies from the,greater ...
... Development of New Route to Administer GAMMAGARD LIQUID(TM) ... Collaboration Valued at Up to $47 Million, ... International Inc. (NYSE: BAX ) and Halozyme ... have entered into an agreement to apply,Halozyme,s proprietary ...
... BERKELEY HEIGHTS, N.J. and RALEIGH, N.C., Sept. ... focused clinical,research organization, today announced the appointments ... Biostatistics and Christopher,Gregory, Ph.D as Scientific Affairs-Director. ... Srinivasan and Gregory, both highly,experienced professionals in ...
Cached Biology Technology:Hyaluron Contract Manufacturing Named a 2007 Economic Impact Award Finalist 2Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 2Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 3Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 4Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 5Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 6Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 7Clinsys Clinical Research, Inc. Announces Key Hires, Rajagopalan Srinivasan, Ph.D, to Strengthen Global Biostatistics Service Offering and Christopher Gregory, Ph.D, to Scientific Affairs 2Clinsys Clinical Research, Inc. Announces Key Hires, Rajagopalan Srinivasan, Ph.D, to Strengthen Global Biostatistics Service Offering and Christopher Gregory, Ph.D, to Scientific Affairs 3Clinsys Clinical Research, Inc. Announces Key Hires, Rajagopalan Srinivasan, Ph.D, to Strengthen Global Biostatistics Service Offering and Christopher Gregory, Ph.D, to Scientific Affairs 4
... offers high performance miniature stepper motors available ... 34 frame sizes. These space-efficient 1.8 2-phase ... applications, including medical instrumentation, medical devices, drug ... Meets a wide range of customer ...
... have been designed to save time and ... interested in eliminating the recycling and resterilizing ... individually packaged, RNase/DNase free, non-pyrogenic and antistatic. ... product number, created to easily match Cornings ...
... bioassays for interferons are cytopathic effect inhibition ... assays. The neutralization assay measures the ... of the cytokine. Sample types include; tissue ... In these assays, one unit is defined ...
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
Biology Products: