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JCI early table of contents for May 24, 2013
Date:5/24/2013

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Dysregulated gene expression is a feature of most cancers. In this issue of the Journal of Clinical Investigation, Gal Markel and colleagues at Chaim Sheba Medical Center in Ramat-Gan, Israel, demonstrated that expression of the RNA editing enzyme ADAR1 is frequently reduced in melanoma that was linked to the development of metastases. Loss of ADAR1 enhanced the growth and tumor-forming ability of the melanoma cells. Markel and colleagues found that ADAR1 normally regulates the expression of microRNAs, molecules that help to control the expression of specific genes. In turn, microRNAs also control the expression of ADAR1. These studies demonstrate that loss of an RNA editing enzyme contributes to the development of a more aggressive, metastatic form of melanoma.

TITLE:
MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

AUTHOR CONTACT:
Gal Markel
Chaim Sheba Medical Center, Ramat-Gan, ISR
Phone: 972-3-5304591; E-mail: markel@post.tau.ac.il

View this article at: http://www.jci.org/articles/view/62980?key=96ee313210f0982ab94b


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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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