Navigation Links
JCI early table of contents for May 24, 2013
Date:5/24/2013

/p>

View this article at: http://www.jci.org/articles/view/69684?key=7b3a1f3b31864a612826

Bone-derived hormone and insulin influence male fertility

The bone cell-derived hormone osteocalcin promotes the production of testosterone in the mouse testis. Interestingly, osteocalcin-deficient mice exhibit increased levels of leutenizing hormone (LH), a pituitary hormone that regulates sex steroid synthesis in the testes. Additionally, osteocalcin levels appear to be linked to insulin secretion and sensitivity and circulating levels of testosterone in humans. In this issue of the Journal of Clinical Investigation, researchers led by Gerard Karsenty at Columbia University conducted a study to determine if LH and insulin regulate osteocalcin's reproductive effects. Using transgenic mice, they found that osteocalcin and LH act in two parallel pathways to stimulate testosterone synthesis. To determine the importance of osteocalcin in humans, they analyzed patients with primary testicular failure, wherein the testes do not produce enough testosterone, and a mutation in a cellular receptor that allows Leydig cells in the testes to respond to osteocalcin. This study uncovers an endocrine axis that is necessary for optimal male fertility in the mouse and suggests that osteocalcin modulates reproductive function in humans.

TITLE:
A pancreas-bone-testis axis and conservation of osteocalcin function in humans

AUTHOR CONTACT:
Gerard Karsenty
Columbia University, New York, NY, USA
Phone: 212 305 4011; E-mail: gk2172@columbia.edu

View this article at: http://www.jci.org/articles/view/65952?key=aa347e9f0247bcf117a6

Loss of RNA editing enzyme promotes melanoma growt
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. Mid-Atlantic suburbs can expect an early spring thanks to the heat of the big city
3. An early spring drives butterfly population declines
4. Hazy shades of life on early Earth
5. American Society of Plant Biologists honors early career women scientists
6. Early warning system for seizures could cut false alarms
7. A new gene thought to be the cause in early-onset forms of Alzheimers disease
8. Promising developments in early diagnosis and treatment of mesothelioma
9. Early detection techniques offer hope for improved outcomes in lung cancer patients
10. New study links air pollution and early death in the UK
11. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... Rio de Janeiro, Brazil -Individuals show great diversity in ... importantly, males and females greatly differ in their perceptual ... kinds of smell tests. , Sex differences ... social behaviors and may be connected to one,s perception ... and emotions. Thus, women,s olfactory superiority has been suggested ...
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... OXFORD, England , November 4, 2014 ... expansion and vertical market growth   Fuel3D ... it has closed a funding round totaling $6.4 million (£4 ... (£1.6 million) funding secured earlier this year and paves the ... product in 2015. The funding round was led ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... the focus of the Society for Nutrition Education,s 2009 ... small step in fighting world hunger. Food security remains ... attention in order to combat the issues of poverty, ... Education (SNE) encourages its members and the public to ...
... SANTA CLARA, Calif., Oct. 9 Synaptics(R),Incorporated (Nasdaq: ... interface,solutions for mobile computing, communications, and entertainment devices,announced ... the first quarter,of fiscal 2009 on Thursday, October ... will host a corresponding conference call for analysts ...
... Researchers at the European Molecular Biology Laboratory (EMBL) have ... developmental blueprint of a vertebrate. With a newly developed ... cells for the first 24 hours in the life ... three-dimensional, digital representation of the embryo. The study, published ...
Cached Biology News:World Food Day brings attention to food security around the globe 2Synaptics to Report First Quarter Results on October 23 2Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate 2
(Date:11/24/2014)... BETHESDA, Md. , Nov. 24, 2014 /PRNewswire/ ... property development company committed to the fostering and ... regarding  Spherix v. VTech Telecommunications Ltd.,  Case No. ... , Case No. 3:13-cv-03496-M, both in the United ... Texas . ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Apiscent ... supplier of fine chemical ingredients to the global ... launch of its new website, Apiscent.com. , The ... Apiscent Labs, clean design, easy navigation, rotating images ... Apiscent Labs stand out. , The ...
(Date:11/22/2014)... During his lifetime Richard L. Sharp was ... himself with great people and take risks to achieve ... marveled at his extraordinarily courageous attitude when taking on ... even with his death impending—that’s how he continued looking ... ultimately take his life. , Carrying on Sharp’s relentless ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 CannLabs, ... cloud based analytics and scientific testing methodologies relating to ... for a $750,000 line of credit from an existing ... pleased to have secured this commitment from one of ... Officer of CannLabs. “This capital will help accelerate our ...
Breaking Biology Technology:Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3CannLabs Secures $750,000 Line Of Credit 2
... - Third Wave Technologies reported a smaller net ... 2006, but the company experienced impressive growth in clinical molecular ... Wave, which develops molecular diagnostic products for use in clinical ... net loss of $22.3 million, or 54 cents per share, ...
... Ken Rheingans' most immediate focus is next weekend's BarCamp ... BarCamp USA , the state's first national technology unconference. ... which will be held August 23-26 on the Jefferson County ... , said organizers would like to draw 5,000 technologists to ...
... this month's meeting of the Wisconsin Innovation Network ... Taxpayers Alliance was asked what single thing was standing ... the state average. , ,Berry, whose organization has been charting ... didn't give a predictable answer about high taxes. Instead, the ...
Cached Biology Technology:Third Wave reports net loss of $18.9M for 2006 2Wisconsin to host technology BarCamp USA 2Wisconsin to host technology BarCamp USA 3Education is fundamental to Milwaukee's growth 2Education is fundamental to Milwaukee's growth 3Education is fundamental to Milwaukee's growth 4
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Yersinia pestis...
C/EBPdelta Antibody Shipping Temperature: Cold Storage Temperature: -20C...
Adenylate kinase isoenzyme 6...
Biology Products: