Navigation Links
JCI early table of contents for May 24, 2013
Date:5/24/2013

ion of an immune system response mechanism known as complement. Normally the complement system helps to clear pathogens from the body. It consists of a number of small proteins that, upon immune activation, are broken up into fragments that bind to foreign material or pathogen-infected cells to trigger their destruction. In C3 glomerulopathies, the complement fragments accumulate in the kidney, causing damage. In this issue of the Journal of Clinical Investigation, Santiago Rodrguez de Crdoba and colleagues at the Centro de Investigaciones Biolgicas in Madrid, Spain identifed mutations in complement regulating protein, factor H, which increased complement activation. These studies help to define how factor H functions in complement regulation and provide a greater understanding of C3 glomerulopathy pathology. As Michael Holers of the University of Colorado explains in the accompanying commentary, variants in factor H genes are linked to multiple autoimmune and inflammatory diseases. Studies like this one may help to direct the development of new therapies.

TITLE:
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

AUTHOR CONTACT:
Santiago Rodrguez de Crdoba
Centro de Investigaciones Biolgicas (CSIC), Madrid, UNK, ESP
Phone: 34 91 8373112; E-mail: srdecordoba@cib.csic.es

View this article at: http://www.jci.org/articles/view/68280?key=10557a92827ab0d588fe

ACCOMPANYING COMMENTARY

TITLE:
Human C3 glomerulopathy provides unique insights into complement factor Hrelated protein function

AUTHOR CONTACT:
Michael Holers
University of Colorado Denver School of Medicine, Denver, CO, USA
Phone: 303-724-7609; E-mail: Michael.Holers@ucdenver.edu<
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. Mid-Atlantic suburbs can expect an early spring thanks to the heat of the big city
3. An early spring drives butterfly population declines
4. Hazy shades of life on early Earth
5. American Society of Plant Biologists honors early career women scientists
6. Early warning system for seizures could cut false alarms
7. A new gene thought to be the cause in early-onset forms of Alzheimers disease
8. Promising developments in early diagnosis and treatment of mesothelioma
9. Early detection techniques offer hope for improved outcomes in lung cancer patients
10. New study links air pollution and early death in the UK
11. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... first high-resolution map of the carbon stocks stored ... The new and improved methodology used to make ... market-based carbon economies. The new carbon map ... it provides the critical input to studies of ... and enforcement purposes. The technique includes the determination ...
(Date:7/29/2014)... Washington, USA The advanced optical methods and applications ... driving a revolution in the neurosciences were the inspiration ... by SPIE, the international society for optics and photonics. ... the BRAIN Initiative in the United States, and a ... for and provide examples of the impact that optics ...
(Date:7/29/2014)... the wrong food at a restaurant, don,t blame yourself; blame ... do with what you want and more to do with ... and the selections of over 300 diners, the Cornell study ... Management showed that when it comes to what you ... on the menu and how you imagine it will taste. ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Menu secrets that can make you slim by design 2
... Scientists at Michigan State University have identified a ... could ultimately lead to plant varieties tailored specifically ... compartments in plant cells, convert sunlight, carbon dioxide ... the plant) during photosynthesis. The newly discovered protein, ...
... researchers are urging companies to embrace new methods for following ... much of the world,s global warming threats. , ... Because there is no universally accepted ... have sprung up on the Internet in the past few ...
... Institute of Technology have developed a novel way ... antiplaque toothpaste additives, antibiotics, nicotine, and even morphine, ... the research, now available online, will be featured ... of Nature Chemical Biology . Christina ...
Cached Biology News:MSU's discovery of plant protein holds promise for biofuel production 2Carnegie Mellon urges industry to broaden carbon footprint calculations 2Caltech engineers build mini drug-producing biofactories in yeast 2
(Date:7/30/2014)... 30, 2014 Vycom announces the addition ... designed to meet Factory Mutual (FM) 4910 fire propagation ... as wet benches, process tools, fume hoods, furniture and ... damage to semiconductor wafers used in electronic chip manufacturing. ... PVC solution with excellent workability and superior aesthetics. It ...
(Date:7/30/2014)... July 30, 2014 Researchers often use ... biology, but such devices can do much more ... As such, researchers have looked to patterned assemblies ... metabolic engineering to characterize – and potentially ... devices are envisioned to recreate animal and human ...
(Date:7/30/2014)... 30, 2014 NCERC at Southern ... present his findings on corn stover pretreatment methods ... week in Washington, D.C. , “Arun’s selection ... is a testament to the success of our ... “Thanks to the foresight and vision of SIUE ...
(Date:7/30/2014)... 2014 Immunology Summit-2014 ... Principle Investigators, scientists in the field, which includes ... at Case Western Reserve University School of Medicine, ... on “The effects of recombinant human IL-6 ... metalloproteinase-9”. Arya Biragyn, a Senior investigator at National ...
Breaking Biology Technology:Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3
... PLEASANTON, Calif., April 20 Thoratec Corporation (Nasdaq: ... circulatory support therapies to save, support and restore failing ... (Pre-Market Approval) supplement with the FDA seeking to add ... the HeartMate II LVAS (left ventricular assist system). The ...
... Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today ... inhibition of novel targets that could offer new mechanisms ... Research (AACR) meeting. Research conducted by Isis and ... non-coding RNA, sigma RNA also known as Malat-1, that ...
... Advanced Instruments, Inc . ... the first true automation-friendly osmometer for the biopharmaceutical ... is specifically designed for -- and completely ... the biopharmaceutical laboratory," said Kelly Peterson, Product Manager, ...
Cached Biology Technology:Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 2Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 3Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 4Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 2Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 3Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 3
...
Lyophilized. Purity: ≥90% by electrophoresis. Reconstitute in 0.3% NaCl. Prepared from serum that has been shown by certified tests to be negative for HBsAg and for HIV and HCV antibodies. ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
PP2B-Abeta (C-20)...
Biology Products: