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JCI early table of contents for May 24, 2013
Date:5/24/2013

nsal bacteria act as guardians of their host environment, controlling the quantity and quality of host gene expression in order to prevent an immune response. To study these responses, Svanborg and colleagues used a strain of E. coli that colonizes the urinary tract but does not cause urinary tract infection symptoms. They found that, unlike bacteria that cause symptoms, the asymptomatic bacteria prevented the activation of inflammatory immune responses. This study identifies a mechanism by which commensal bacteria may establish a beneficial relationship with their host. In an accompanying Attending Physician article, Patrick Seed discusses how commensal bacteria could potentially be used as therapeutics in patients with recurrent urinary tract infections.

TITLE:
Bacterial control of host gene expression through RNA Polymerase II

AUTHOR CONTACT:
Catharina Svanborg
Labmedicin dep of Microbiology, immunology and glycobiology, Lund, SWE
Phone: +46 46 17 39 72; Fax: +46 46 13 74 68; E-mail: Catharina.Svanborg@med.lu.se

View this article at: http://www.jci.org/articles/view/66451?key=f25917427aa8c2f8df1f

ACCOMPANYING THE ATTENDING PHYSICIAN

TITLE:
Anger management: bacteria soothe the savage host

AUTHOR CONTACT:
Patrick Seed
Duke Univeristy School of Medicine, Durham, NC, USA
E-mail: patrick.seed@duke.edu

View this article at: http://www.jci.org/articles/view/69647?key=a6f206b44e10bd4e877c

Familial kidney disorder reveals inner workings of a portion of the immune system

C3 glomerulopathy refers to a group of kidney conditions characterized by innappropriate activat
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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