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JCI early table of contents for May 24, 2013
Date:5/24/2013

ticles/view/68760?key=36efa8d5d66021c0e322">http://www.jci.org/articles/view/68760?key=36efa8d5d66021c0e322

ACCOMPANYING COMMENTARY

TITLE:
RNA-guided diagnostics and therapeutics for next-generation individualized nanomedicine

AUTHOR CONTACT:
Gennadi Glinsky
Stanford University Medical School, Stanford, CA, USA
Phone: 858-401-3470; E-mail: gglinsky@stanford.edu

View this article at: http://www.jci.org/articles/view/69268?key=7c5b7c952e03e5ae6be5

Malnutrition exacerbates Giardia infection in mice

Giardia is a common parasite that frequently infects young children in the developing world. It is commonly encountered through contaminated food, soil, or water. The parasite lives inside the intestines and can cause severe diarrhea and other gastrointestinal problems and Giardia infection has been associated with developmental growth delays. Because the majority of infected individuals do not experience symptoms and frequently are infected with other pathogens, it is unclear if endemic Giardia directly stunts growth. In this issue of the Journal of Clinical Investigation, Luther Bartelt and colleagues at the University of Virginia studied the effect of Giardia infection in a malnourished host. Malnourished mice exposed to Giardia developed a worse symptoms, including inflammation, intestinal damage, and growth retardation. These findings suggest that malnourishment puts children at greater risk for symptomatic Giardia infection. In the related Attending Physician piece, Theodore Nash describes how this single infectious agent can have dramatically different effects depending on an individual's health history. As Herbert DuPont explains in the accompanying commentary, although preexisting nutritional state undoubtedly plays a role, the v
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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