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JCI early table of contents for Mar. 15, 2013

start of treatment and then retransplanted following remission; however, there is a potential risk of reintroducing malignant material during transplantation. To overcome this hurdle, Serena Dovey and colleagues at the University of Pittsburgh characterized the cell surface markers of human spermatogonia in testicular tissue from organ donors. In this issue of the Journal of Clinical Investigation, Dovey and colleagues report the development of a multi-parameter sorting approach to separate SSCs from cancerous cells. Sorted SSCs exhibited were able to function properly when transplanted into mice, but did not form tumors. These results suggest that SSC transplantation could be a viable method to preserve fertility in male childhood cancer survivors.

Eliminating malignant contamination from therapeutic human spermatogonial stem cells

Kyle Orwig
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Phone: 412-641-2460; Fax: 412-641-3899; E-mail:

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Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells

Giovanni Melillo
Bristol-Myers Squibb, Princeton, NJ, USA
Phone: 609-2526975; Fax: 609-252-7821; E-mail:

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Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis

Xian-Cheng J

Contact: Jillian Hurst
Journal of Clinical Investigation

Page: 1 2 3 4

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