Navigation Links
It's a trap! New laboratory technique captures microRNA targets
Date:5/9/2012

LA JOLLA, Calif., May 9, 2012 Human cells are thought to produce thousands of different microRNAs (miRNAs)small pieces of genetic material that help determine which genes are turned on or off at a given time. miRNAs are an important part of normal cellular function, but they can also contribute to human diseasesome are elevated in certain tumors, for example, where they promote cell survival. But to better understand how miRNAs influence health and disease, researchers first need to know which miRNAs are acting upon which genesa big challenge considering their sheer number and the fact that each single miRNA can regulate hundreds of target genes. Enter miR-TRAP, a new easy-to-use method to directly identify miRNA targets in cells. This technique, developed by Tariq Rana, Ph.D., professor and program director at Sanford-Burnham Medical Research Institute (Sanford-Burnham), and his team, was first revealed in a paper published May 8 by the journal Angewandte Chemie International Edition.

"This method could be widely used to discover miRNA targets in any number of disease models, under physiological conditions," Rana said. "miR-TRAP will help bridge a gap in the RNA field, allowing researchers to better understand diseases like cancer and target their genetic underpinnings to develop new diagnostics and therapeutics. This will become especially important as new high-throughput RNA sequencing technologies increase the numbers of known miRNAs and their targets."

How miR-TRAP works

miRNAs block gene expression not by attaching directly to the DNA itself, but by binding to messenger RNA (mRNA), the type that normally carries a DNA recipe out of the nucleus and into the cytoplasm, where the sequence is translated into protein. Next, these RNAs are bound by a group of proteins called the RNA-induced silencing complex, or RISC. This blocks production of the protein encoded by that mRNA, an action that can have far-reaching c
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
2. Very cold ice films in laboratory reveal mysteries of universe
3. Gene therapy corrects sickle cell disease in laboratory study
4. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
5. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
6. Childrens Hospital Oakland is first pediatric hospital to use laboratory-on-a-card technology
7. Story tips From the Department of Energys Oak Ridge National Laboratory -- May 2009
8. Story tips from the Department of Energys Oak Ridge National Laboratory, June 2009
9. General tumor marker test now offered by GenWay clinical laboratory
10. 2 neuroscientists from Cold Spring Harbor Laboratory awarded transformative NIH grants
11. Story tips from the US Department of Energy’s Oak Ridge National Laboratory February 2010
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
It's a trap! New laboratory technique captures microRNA targets
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, a ... authentication solutions, today announced enhanced functionality of its ... solution.  The enhancements build on the native ... DigitalPersona Altus platform and provide expanded mobile ... In today,s environment of increasing cyber-attacks ...
(Date:6/17/2015)... SAN JOSE, Calif. , June 17, 2015 ... leader in human interface solutions, today announced that ... has adopted the Synaptics ® ClearPad ® ... family of display driver integrated circuits (DDICs) for ... Note Pro. By leveraging ClearPad for full in-cell ...
(Date:6/16/2015)... -- Fingerprint Cards (FPC) raises the revenue guidance ... to at least 340 MSEK to that it will amount ... market growth and orders received the revenue guidance for 2015 ... 2015 will exceed 1,500 MSEK to an updated guidance that ... Due to receipt of orders of touch fingerprint sensors ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... N.Y. A new book, Grounds ... of historic and modern buildings and the striking landscape that ... tree enthusiast Elizabeth L. Watson, who, together with her husband ... homes on the picturesque grounds of CSHL for almost four ...
... 2008) The Institute for Genomics and Systems Biology (IGSB), ... Argonne National Laboratory and the University of Chicago, has acquired ... genomes more quickly and broadly. "Sequencing used to ... the fairway, but not the rough," said IGSB Director Kevin ...
... N.Y. The appointment of James Watson as ... off an explosive development of research at Cold Spring ... teams of investigators with diverse scientific interests. In ... the scientists involved tell the stories of research carried ...
Cached Biology News:Argonne-University of Chicago joint venture bolsters genomic sequencing capabilities 2Watson-inspired innovation in research at Cold Spring Harbor Laboratory 2
(Date:7/6/2015)... ... July 06, 2015 , ... Discovery of new biomarkers for ... drivers of the global molecular diagnostics market. BCC Research reveals in its new ... companion diagnostic tests will increase demand for inexpensive and accurate tests for genetic ...
(Date:7/6/2015)... 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), a company ... , Viveve,s Chief Executive Officer, and Scott Durbin , ... July 9, 2015. , , , DATE:    ... , , TIME:     , , , 12:15 PM ... , http://tinyurl.com/viveve   ,    ...
(Date:7/6/2015)... ANGELES , July 6, 2015 ImmunoCellular ... establishment of an agreement with Novella Clinical ... ICT-107 in patients with newly diagnosed glioblastoma. Novella is ... trial services to small to mid-sized oncology companies. The ... sites in the US, Europe ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... use in applications such as animal waste reduction, bioremediation, wastewater treatment, aquaculture ... kitchen settings, announced today that it will be showcasing, ManureMagicâ„¢, its industry-leading ...
Breaking Biology Technology:Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2DryLet to Highlight Benefits of Patented ManureMagicâ„¢ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2
... , , NEW ... market research report is available in its catalogue: , ... , http://www.reportlinker.com/p0170008/Infectious-Disease-Molecular-Diagnostic-Testing.html , The ... market needs for major infectious diseases, as well as ...
... ... Industry Issues in 2010, puts healthcare cost control at the head of the list as the ... ... 10 Health Industry Issues in 2010, puts healthcare cost control at the head ...
... , ... develop proprietary medical food, functional food, and dietary supplement products with strong scientific roots ... ... -- WellGen, Inc., a biotechnology company at the crossroads of foods and pharmaceuticals, and ...
Cached Biology Technology:Reportlinker Adds Infectious Disease Molecular Diagnostic Testing 2Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 2Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 3Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 4Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 5WellGen, Inc. and RFI Ingredients to Collaborate on Therapeutic Nutrition Opportunities 2WellGen, Inc. and RFI Ingredients to Collaborate on Therapeutic Nutrition Opportunities 3
... ALH 3000 workstation automates a wide array ... and Proteomic Sample Preparation to Bio-Molecular and ... design of the Caliper Sciclone enables numerous ... perfectly meet the needs of a given ...
Designed for use with the Agencourt SprintPrep 384 kit and all MCPrep reagent kits. Used with flat bottom 96-well microplates such as deep well plates used to culture bacteria....
... TRAC is a platform for fully ... applications. It can easily be configured for ... to molecular biology.TRAC allows closed loop screening, ... screen, hit list generating, cherry picking and ...
... devices for the fast and reliable clarification/filtration of ... 500 l. They can be used in fixed ... Features: High-flux Polyethersulphonemembrane 0.8 ... volume ( Fast and reproducible performance ...
Biology Products: