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It must be important but what does it do? The strange case of UCP2
Date:8/17/2012

Their results showed clearly that UCP2 was preferentially expressed in cells related to the immune system and not, as generally believed, in neurons.

The implication was that UCP2 might somehow be involved in immune function. This surprising idea was tested by examining the change in UCP2 levels in T cells that were stimulated into action by a specific antigen. Stimulation indeed caused an increase in the amount of UCP2 in the cells. This was paralleled by increases in the concentrations of other proteins known to be produced in response to T-cell activation. When the cells were further stimulated seven and fourteen days later the amount of UCP2 increased although the amounts of the other proteins investigated did not.

It is attractive to speculate that the increase in UCP2 might be involved in signalling T-call stimulation but Pohl is quick to quash the notion. "Anne showed that the increase in UCP2 only starts a few hours after activation of T cells, while other events are seen much sooner. UCP2 thus arrives too late to be involved in stimulating the cells, so the increase must be related to overall metabolic changes in proliferating cells. This fits with our observation that UCP2 is not found in neurons, which no longer proliferate" In other words, although we still cannot be sure of the exact function of this intriguing protein, "at least we now know where to start looking!" And the finding that UCP2 is required by fast proliferating cells may have important consequences for the development of treatments for immune disorders, such as autoimmune and neurodegenerative diseases, and perhaps also for other diseases where cells divide rapidly, such as cancer.


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Contact: Elena Pohl
Elena.Pohl@vetmeduni.ac.at
43-650-366-3205
University of Veterinary Medicine -- Vienna
Source:Eurekalert

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