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It is important to demonstrate the influence of the microenvironment in the process of metastasis
Date:12/20/2007

44,000 genes at the same time. It was observed that one group of genes is regulated in the same way by both hepatocytes and myofibroblasts, but there are other groups that are regulated in a specific manner way by either hepatocytes or myofibroblasts. That is to say, genes regulated in the presence of conditioned media are different, depending on the cells. The biologist also observed that the hepatocytes regulate a significantly greater amount of genes than do the myofibroblasts.

This study is only at its beginnings stated the researcher. Although we have possibly identified certain genes, further studies have to be undertaken. And, undoubtedly this is a field which will widen. The results so far obtained have to be corroborated with much wider studies, with a much larger number of patients, and so on, she added.

But, basically, I think it important to demonstrate the influence of the microenvironment in the process of metastasis, she argued. When studying cancer, it is good to have a more global, overall perspective, not solely focusing on the tumour or malignant cells.

If we manage to find out the process of regulation in the tumour cell during metastasis, we will have achieved the possibility of developing therapeutic targets in order to try and avoid, as it were, the metastasis occurring.


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Contact: Irati Kortabitarte
iratik@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

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