Navigation Links
Isogenic cell models for cancer research exclusively licensed to Horizon Discovery
Date:12/9/2010

CLEVELAND With the goal of developing new, more effective and personalized cancer treatments, Horizon Discovery, based in Cambridge, England, has secured from Case Western Reserve University exclusive rights to a panel of new human isogenic cell models developed by the laboratory of Zhenghe John Wang, assistant professor of genetics at the university's School of Medicine.

The license is initially for 10 years and includes up-front fees and an ongoing royalty on product sales. The genetically engineered cell lines are based on a new technology invented by Wang and his associates two years ago.

Human isogenic cell models known as cell lines and sometimes referred to as "patients-in-a-test-tube" accurately mimic disease-causing mutations, enabling researchers to better understand how cancer manifests itself in patients and to identify the effect of drug therapies and various outcomes.

"These cell lines provide unique tools for drug discovery, because they are cells that best represent human cancers. Further research based on these cells may lead to development of new cancer therapies," Wang said.

The lines will be added to Horizon Discovery's rapidly expanding library of X-MANTM (gene X- Mutant And Normal) cell models, which are used to successfully predict which patient groups will respond to currently available and future drug treatments. Research involving Horizon Discovery's proprietary rAAV GENESIS gene-editing platform seeks to enhance drug development, leading to personalized cancer therapies.

Chris Torrance, Horizon Discovery's co-founder and chief scientific officer, said that the cell lines will help researchers decipher how disease-associated genes work and "will open up new routes to develop novel targeted therapies."

"In partnering with Horizon, we gain a tremendous opportunity to bring these unique cancer cell lines to the market," said Stacy Fening, licensing associate for life sciences in
'/>"/>

Contact: Marv Kropko
mrk107@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Metabolism models may explain why Alzheimers disease kills some neuron types first
2. Study improves accuracy of models for predicting ozone levels in urban areas
3. Scientists create 3-D models of whole mouse organs
4. Study paves way for new biofuels models, technologies
5. Species distribution models can exaggerate differences in environmental requirements
6. Biochemist researching computer models of protein structure that help high school, college students
7. Animal models that help translate regenerative therapies from bench to bedside
8. Computer models suggest vaccination or culling best to prevent foot-and-mouth disease
9. Small molecules found to protect cells in multiple models of Parkinsons disease
10. Species distribution models are of only limited value for predicting future mammal distributions
11. Caltech researchers show efficacy of gene therapy in mouse models of Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... A UT Arlington bioengineering professor has received a ... aims to regenerate cartilage tissue and reduce osteoarthritis ... the injection of microscaffolding made of biodegradable polymers., ... of the bioengineering department, said the research is ... injured on the battlefield., "We,ve found that if ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... study of its kind to date, researchers have used ... the risk for autism. Joseph Buxbaum, Ph.D., Icahn School ... Daly, Ph.D., Broad Institute of Harvard and MIT, and ... affected children, parents and unrelated people. They identified changes ... the risk for autism spectrum disorder (ASD) – a ...
Breaking Biology News(10 mins):UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2New tech aims to improve communication between dogs and humans 2
... German . , Pacific Grove (CA)/Leipzig. ... sequences and function of two proteins in mussels that ... proteins form part of an active, physiological barrier in ... from the Helmholtz Centre for Environmental Research (UFZ) in ...
... Calif., Oct. 8 Lee Shupp, executive VP,at ... evolving consumer,expectations and imaging technologies are leading to ... Future of Imaging Conference, to be,held Nov. 18-20 ... The,conference will explore the transformative impact of recent ...
... Valley Virus-001, reveals that it is unlike any other known ... designation as a separate genus "Senecavirus." The new study reveals ... golf ballone with uneven divets and raised spikesand the RNA ... like a whiffleball. "It is not at all like ...
Cached Biology News:What causes cell defenses to crumble? 2What causes cell defenses to crumble? 3Cheskin Added Value EVP Lee Shupp Discusses Evolving Dynamics of Consumers and Imaging Tech at 6Sight 2Scripps research team solves structure of 'beneficial' virus 2
(Date:10/30/2014)... October 29, 2014 Global polyvinyl chloride ... world economic crisis during 2008-2009, especially in North America ... and currently is keeping to a growing trend. , ... is utilized in the construction segment. In 2013, the ... profiles, tubing, sheets and rigid film. Moreover, the PVC ...
(Date:10/30/2014)... James Sherley says he has been working towards ... since his days as a principal investigator at the Fox ... Sherley founded the ASCTC as a new Boston biotech ... property developed in Sherley’s research over the years since FCCC, ... (MIT), and more recently as a senior scientist at the ...
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), the leader ... company overview at the Nomura Biotechnology Conference on Thursday, November ... MA. A live webcast of the ... of the Company,s website, www.isispharm.com .  A replay will ... will be archived for a limited time. About ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at ... with Bryan Hamilton, the publisher of the Triangle Business Journal, ... the Research Triangle region of North Carolina. , Just a ... roundtable include the role of social media in recruitment, ... and the unique role that Millennials play in the workplace ...
Breaking Biology Technology:Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
... Outlines Pathway to Potential Approval, WOODCLIFF LAKE, ... today announced that it has received a not ... (FDA), which outlines a pathway,to potential approval of ... disodium injection has been in review at,the FDA ...
... Over 300 of,China,s top stem cell biologists and ... and held China,s first ever symposium on,advanced induced ... first annual 2008 China Stem Cell Technology Forum ... At the Forum, which was chaired by,Dr. Sean ...
... Insmed Inc. (Nasdaq:,INSM), a developer of follow-on biologics ... conference call on Friday, August 8th at 8:30,AM ... quarter 2008. Insmed intends,to issue its quarterly financial ... 8th., To participate in the live conference ...
Cached Biology Technology:Eisai Receives Action Letter on Fospropofol Disodium Injection for Sedation in Diagnostic or Therapeutic Procedures 2Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells 2Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells 3Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells 4Insmed to Host Second Quarter 2008 Conference Call 2