Navigation Links
Isogenic cell models for cancer research exclusively licensed to Horizon Discovery
Date:12/9/2010

CLEVELAND With the goal of developing new, more effective and personalized cancer treatments, Horizon Discovery, based in Cambridge, England, has secured from Case Western Reserve University exclusive rights to a panel of new human isogenic cell models developed by the laboratory of Zhenghe John Wang, assistant professor of genetics at the university's School of Medicine.

The license is initially for 10 years and includes up-front fees and an ongoing royalty on product sales. The genetically engineered cell lines are based on a new technology invented by Wang and his associates two years ago.

Human isogenic cell models known as cell lines and sometimes referred to as "patients-in-a-test-tube" accurately mimic disease-causing mutations, enabling researchers to better understand how cancer manifests itself in patients and to identify the effect of drug therapies and various outcomes.

"These cell lines provide unique tools for drug discovery, because they are cells that best represent human cancers. Further research based on these cells may lead to development of new cancer therapies," Wang said.

The lines will be added to Horizon Discovery's rapidly expanding library of X-MANTM (gene X- Mutant And Normal) cell models, which are used to successfully predict which patient groups will respond to currently available and future drug treatments. Research involving Horizon Discovery's proprietary rAAV GENESIS gene-editing platform seeks to enhance drug development, leading to personalized cancer therapies.

Chris Torrance, Horizon Discovery's co-founder and chief scientific officer, said that the cell lines will help researchers decipher how disease-associated genes work and "will open up new routes to develop novel targeted therapies."

"In partnering with Horizon, we gain a tremendous opportunity to bring these unique cancer cell lines to the market," said Stacy Fening, licensing associate for life sciences in
'/>"/>

Contact: Marv Kropko
mrk107@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Metabolism models may explain why Alzheimers disease kills some neuron types first
2. Study improves accuracy of models for predicting ozone levels in urban areas
3. Scientists create 3-D models of whole mouse organs
4. Study paves way for new biofuels models, technologies
5. Species distribution models can exaggerate differences in environmental requirements
6. Biochemist researching computer models of protein structure that help high school, college students
7. Animal models that help translate regenerative therapies from bench to bedside
8. Computer models suggest vaccination or culling best to prevent foot-and-mouth disease
9. Small molecules found to protect cells in multiple models of Parkinsons disease
10. Species distribution models are of only limited value for predicting future mammal distributions
11. Caltech researchers show efficacy of gene therapy in mouse models of Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ... Generation Biometrics Market by Application, Technology, Function & Geography ... offering. The next generation biometrics market is ... CAGR of 17.9% between 2015 and 2020 ... market. Safran SA ( France ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
(Date:6/25/2015)... -- TAKE Solutions Ltd., a global business technology solutions provider, ... and Trademark Office (USPTO) for its "Method for Optimizing ... Accelerators to reduce the time taken to standardize trial ... the accelerators), thus reducing time to market. ... heart of the patented Clinical Data Standardization Process are ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2TAKE Solutions Awarded Patent By USPTO 2
... German . Much celebration at the ... has approved funding for a long-term research project by Professors ... and Dr. Frank Spinath from Saarland University. They are studying ... 4,000 pairs of twins living in Germany. The name of ...
... to a new study from the Slone Epidemiology Center (SEC) ... age 11 had a greater likelihood of adult-onset asthma compared ... The study, which is published online in ... led by Patricia Coogan, DSc, senior epidemiologist at SEC and ...
... discovered by a Northwestern University professor and now tested ... been shown to alleviate symptoms within hours, have good ... seven days from a single dose. The ... memory -- a very different approach from existing antidepressants. ...
Cached Biology News:German Research Foundation to fund globally unique twin study on social inequality 2Abuse during childhood linked to adult-onset asthma in African-American women 2New antidepressant acts very rapidly and is long lasting 2New antidepressant acts very rapidly and is long lasting 3
(Date:7/2/2015)... 2, 2015 College of DuPage students ... gaining invaluable real-world experiences while serving biophysics internships at ... The students will be working as a part ... at IIT. The internship came about from a ... Physics; Dr. Kathy Finan , Biology; and Dr. ...
(Date:7/1/2015)... ... 2015 , ... It is now possible to separate two common disorders: post-traumatic ... tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas Jefferson University, and ... is believed to be the largest brain imaging study ever, will be published on ...
(Date:7/1/2015)... PALO ALTO, Calif. , July 1, 2015 ... company focused on the development of groundbreaking drugs ... sclerosis (ALS), announced today that Robert G. ... Research Center at Sutter Health,s California Pacific Medical ... from The ALS Association for $1.5 million to ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that company CEO, ... PA. , The presentation took place on Tuesday, June 16 and provided ... development of APX3330 for the treatment of pancreatic cancer. A copy of the ...
Breaking Biology Technology:COD Students Participate in Prestigious Summer Internships 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2
... Large Well-Known Product and Continues ... of Antibody Therapeutics Pipeline -, BRITISH COLUMBIA, Canada, ... TSX Venture: IXS;, http://www.ixsbio.com ), a drug development company ... Dynamic Cross Linking,(DXL(TM)) technology, announces the development of a ...
... reported results for the quarter ended September 30, 2008.,Revenue ... to $112,000 for,the quarter ended September 30, 2007. Revenue ... compared to $715,000 for the nine months,ended September 30, ... quarter of 2008 were,$17.3 million compared to $19.8 million ...
... Residual Vascular Risk Reduction: The Global Call to Action, ... Initiative:,R3i, KEY FACTS:, Residual Risk Reduction Initiative (R3i) ... unaddressed by current standards of,care in millions of patients with ... Audubon Room, Ritz Carlton Hotel, 921 Canal Street, New Orleans, ...
Cached Biology Technology:InNexus Biotechnology Announces New EGFR Antibody DXL1218 Targeting Colorectal Cancer and Announces $1.25 Million Private Placement 2InNexus Biotechnology Announces New EGFR Antibody DXL1218 Targeting Colorectal Cancer and Announces $1.25 Million Private Placement 3Dendreon Reports Third Quarter 2008 Financial Results 2Dendreon Reports Third Quarter 2008 Financial Results 3Dendreon Reports Third Quarter 2008 Financial Results 4Dendreon Reports Third Quarter 2008 Financial Results 5
Duck polyclonal to Cobra venom - Fab Fragment ( Abpromise for all tested applications). Antigen: Snake Venom of N. naja arta...
Anti-human C5a/C5a des-Arg (neo-epitode), Clone 2952, Monoclonal Antibody...
...
Reacts with the 80 kDa fragment of the M-chain of human merosin....
Biology Products: