Navigation Links
Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia?
Date:5/26/2009

Amsterdam, The Netherlands, May 26, 2009 There are several risk factors for the development of Alzheimer's disease and vascular dementia. Based on an increasing number of studies linking these risk factors with Vitamin D deficiency, an article in the current issue of the Journal of Alzheimer's Disease (May 2009) by William B. Grant, PhD of the Sunlight, Nutrition, and Health Research Center (SUNARC) suggests that further investigation of possible direct or indirect linkages between Vitamin D and these dementias is needed.

Low serum levels of 25-hydroxyvitamin D [25(OH)D] have been associated with increased risk for cardiovascular diseases, diabetes mellitus, depression, dental caries, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia or have preceded incidence of dementia. In 2008, a number of studies reported that those with higher serum 25(OH)D levels had greatly reduced risk of incidence or death from cardiovascular diseases.

Several studies have correlated tooth loss with development of cognitive impairment and Alzheimer's disease or vascular dementia. There are two primary ways that people lose teeth: dental caries and periodontal disease. Both conditions are linked to low vitamin D levels, with induction of human cathelicidin by 1,25-dihydroxyvitamin D being the mechanism.

There is also laboratory evidence for the role of vitamin D in neuroprotection and reducing inflammation, and ample biological evidence to suggest an important role for vitamin D in brain development and function.

Given these supportive lines of evidence, Dr. Grant suggests that studies of incidence of dementia with respect to prediagnostic serum 25(OH)D or vitamin D supplementation are warranted. In addition, since the elderly are generally vitamin D deficient and since vitamin D has so many health benefits, those over the age of 60 years should consider having their serum 25(OH)D tested, looking for a level of at least 30 ng/mL but preferably over 40 ng/mL, and supplementing with 1000-2000 IU/day of vitamin D3 or increased time in the sun spring, summer, and fall if below those values.

Writing in the article, Dr. Grant states, "There are established criteria for causality in a biological system. The important criteria include strength of association, consistency of findings, determination of the dose-response relation, an understanding of the mechanisms, and experimental verification. To date, the evidence includes observational studies supporting a beneficial role of vitamin D in reducing the risk of diseases linked to dementia such as vascular and metabolic diseases, as well as an understanding of the role of vitamin D in reducing the risk of several mechanisms that lead to dementia."


'/>"/>

Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related biology news :

1. Low levels of vitamin D linked to common vaginal infection in pregnant women
2. Vitamin D expert receives Linus Pauling Prize for Health Research
3. Vitamin D insufficiency linked to bacterial vaginosis in pregnant women
4. Vitamin D levels linked to asthma severity
5. Vitamin D may exacerbate autoimmune disease
6. Vitamin D deficiency related to increased inflammation in healthy women
7. Low levels of vitamin B12 may increase risk for neural tube defects
8. New reference material can improve testing of multivitamin tablets
9. Genetic study shows direct link between vitamin D and MS susceptibility gene
10. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
11. Vitamin D deficiency in infants and nursing mothers carries long-term disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, ... modular downlights designed to stay tightly sealed and perform efficiently for years. The ... wet location listings just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; ...
(Date:8/14/2017)... Ca (PRWEB) , ... August 14, 2017 , ... ... poorly characterized and performing antibodies. Key researchers in the antibody community have recently ... characterization and consistency for antibodies in the laboratory. , The team ...
(Date:8/11/2017)... (PRWEB) , ... August 11, 2017 , ... A staple ... campaign this month that will incorporate important key elements including a new digital marketing ... community that has supported them, Bill Miller has partnered with the South Texas Blood ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... next week-- as students. From August 14th through the 16th, the University City ... debuted in the summer of 2016, provides Philadelphia-based middle school educators an opportunity ...
Breaking Biology Technology: