Navigation Links
Is the shape of a genome as important as its content?
Date:10/29/2010

tion of specific genes through a microscope. With these data, the researchers were able to create detailed three-dimensional computer models of the yeast genome.

Using this novel approach, the researchers can view genes as they interact with each other. Noma and his colleagues can view where highly active genes are located, or see if genes that are turned on and off together also reside near each other in the three-dimensional structure of the genome. In total, the Wistar researchers also studied 465 so-called gene ontology groups groups of genes that share a related purpose in the cell, such as structure or metabolism.

"When the chromosomes come together, they fold into positions that bring genes from different chromosomes near each other," Noma said. "This positioning allows the processes that dictate how and when genes are read to operate efficiently on multiple genes at once."

This structure is not merely an accident of chemical attractions within and among the chromosomes although that is certainly a part of the larger whole but an arrangement guided by other molecules in the cell to create a mega-structure that dictates genetic function, Noma says. He envisions a scenario where accessory molecules, such as gene-promoting transcription factors, bind to DNA and contribute to the ultimate structure of the genome as the chromosomes fold together.

"I believe we are looking at a new way to visualize both the genome itself and the movements of all the various molecules that act on the genome," Noma said.

According to the Wistar scientists, their techniques are scalable to the human genome, even though fission yeast only has three chromosomes. In fact, the researchers found signs of "transcription factories" clusters of related genes that are read, or "transcribed," at discrete sites which have been proposed to exist in mammals.


'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Penn scientists discover cells reorganize shape to fit the situation
2. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
3. Apple or pear shape is not main culprit to heart woes -- its liver fat
4. Ancient magma superpiles may have shaped the continents
5. Root system architecture arises from coupling cell shape to auxin transport
6. Shape changes in aroma-producing molecules determine the fragrances we detect
7. Root system architecture arises from coupling cell shape to auxin transport
8. As super-predators, humans reshape their prey at super-natural speeds
9. Grape shapes
10. Caltech and UCSD researchers shed light on how proteins find their shapes
11. RNA research strategy for Europe takes shape
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Is the shape of a genome as important as its content?
(Date:7/11/2014)... 2014 Researchers have pioneered a revolutionary new ... technology, called Virtual Finger, allows scientists to move ... and synapses using the flat surface of their ... imaging studies orders of magnitude more efficient, saving ... across many areas of experimental biology. The software ...
(Date:7/11/2014)... hippocampus, the marginal division of the striatum is ... the impact degree of substance P in the ... Yan Yu and his team, College of Biophotonics, ... staining, that substance P receptor, neurokinin 1 was ... division of normal rats. Unilateral or bilateral injection ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... the "International Biometrics Technology Market - Industry Analysis ... report to their offering. ... attacks and crimes has created a need for high ... methods used for personnel authentication such as username and ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... the Hebrew University of Jerusalem have achieved, for the ... cells of Fragile X patients. The discovery paves the ... gene expression in Fragile X patients. Fragile X ... retardation, affecting hundreds of thousands of patients worldwide. The ...
... differences between plants and animals, subtle ones lie concealed within ... animal cells, the nucleus contains DNA, which condenses into ... counted at that stage, revealing the chromosome number ... number spans a relatively short range across animal species (2-296: ...
... (Santa Barbara, Calif.) After an announcement by federal ... searching for a way to treat Alzheimer,s Disease are ... them to test a therapy for a genetically predestined ... incredible," said UC Santa Barbara neuroscientist Ken Kosik, who ...
Cached Biology News:Stem cell research paves way for progress on dealing with Fragile X retardation 2Does polyploidy play a role in the onset of the Italian endemic flora? 2Clinical trials for Alzheimer's disease preventative drug to begin early 2013 2Clinical trials for Alzheimer's disease preventative drug to begin early 2013 3
(Date:7/11/2014)... July 11, 2014 BCC Research ( ... DIGITAL POLYMERASE CHAIN REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS , ... technology reached nearly $140 billion in 2013. This is ... a five-year compound annual growth rate (CAGR) of 28.6%. ... of interesting and exciting possibilities within the broader PCR ...
(Date:7/11/2014)... 11, 2014 Cayenne Medical, Inc., ... in the soft tissue reconstruction segment, announced the ... for surgeries involving the shoulder and extremities. The ... novel, inserter-controlled deployment method. The unique delivery eliminates ... anchor pull-out, or anchor displacement (also commonly know ...
(Date:7/10/2014)... 2014 Understanding the need for better ... and the gap that currently exists in this area, ... industry-leading portfolio of validated ion channel and GPCR cell ... lines, as ion channels control many critical physiological functions ... creates the potential to treat a variety of human ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4
... Madison Internet service provider SupraNet plans to ... the Aidmatrix Foundation, a global disaster-relief firm run by ... CEO Bryan Chan said in a press release that ... number of recent disasters the charity is responding to, ...
... of Wisconsin-Madison MBA program was ranked 51st in ... U.S. public university programs by the London Financial Times ... , ,These rankings are based on alumni careers and ... data provided by the schools and a survey of ...
... development assessment group for its high quality of life and ... States, released last week by the non-profit Corporation for Enterprise ... in business vitality and development capacity, based on 2004 data. ... subcategories that made up those three overall marks. , ,Perhaps ...
Cached Biology Technology:
Syd-2 (cL-19)...
Anti-MD-2 (IN) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C...
TNFalpha-IP 2 (G-17)...
The product contains 2 ml Dynabeads® Epoxy (4.5 μm). Supplied at 4 x 10e8 beads/ml...
Biology Products: