Navigation Links
Is the gut microbiome a potential cause and therapeutic target for autoimmune diseases like multiple sclerosis?
Date:8/7/2014

Numerous risk factors are believed to contribute to the development of autoimmune disorders such as multiple sclerosis, and new research is focusing on the role that bacteria in the gastrointestinal tract as well as other cell stress-related chemical signals could have in stimulating inflammation in the central nervous system and activating immunostimulatory cytokines. Two comprehensive Review articles are part of a focus on "Cytokines in Neuroinflammation and Immunity" in a special issue of Journal of Interferon & Cytokine Research (JICR), a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The articles are available free on the JICR website.

Kiel Telesford and Lloyd Kasper, Geisel School of Medicine at Dartmouth University (Lebanon, NH) and Javier Ochoa-Repraz, University of California-Santa Barbara, describe three key characteristics of the gut microbiome related to immune cell activity and cytokine production that may be relevant to susceptibility to and treatment of autoimmune disorders such as multiple sclerosis. In the article "Gut Commensalism, Cytokines, and Central Nervous System Demyelination," the authors note that our understanding of the biology of the gut microbiome and the immunoregulatory potential of bacteria and parasites in the gut is still in its infancy.

In the Review article "Interferons, Signal Transduction Pathways, and the Central Nervous System," Shreeram Nallar and Dhan Kalvakolanu, University of Maryland School of Medicine, Baltimore, explore in detail the latest research pointing to the role of cytokines, and in particular interferons, in contributing to the development of diseases affecting the central nervous system. The authors discuss the potential effects of either an excess or lack of interferons, the inflammatory effects of cytokines, and new therapeutic research strategies.

"The communications between the microbial community in the gut and the host immune system is turning out to be remarkably complex and is likely to impact on many aspects of both health and disease," says Editor-in-Chief Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation, Ohio.


'/>"/>
Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. BGI presents a high-quality gene catalog of human gut microbiome
2. New research finds that cell phones reflect our personal microbiome
3. Good bacteria armed with antibiotic resistance protect gut microbiome
4. Cancer, bioelectrical signals and the microbiome connected
5. Research suggests human microbiome studies should include a wider diversity of populations
6. Report answers questions about the human microbiome and its role in health, obesity
7. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
8. Microbiome in gut, mouth, and skin of low birth weight infants differentiate weeks after birth
9. NIH launches first phase of microbiome cloud project
10. Lab-on-a-chip tech, brain mapping & microbiome highlighted at translational med meeting
11. A home for the microbiome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Is the gut microbiome a potential cause and therapeutic target for autoimmune diseases like multiple sclerosis?
(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
(Date:2/8/2017)... 2017 Report Highlights The global ... $8.3 billion in 2016 at a compound annual growth ... Report Includes - An overview of the global market ... data from 2015 and 2016, and projections of compound ... the market on the basis of product type, source, ...
(Date:2/6/2017)... 2017 According to Acuity Market Intelligence, ... authorities to continue to embrace biometric and digital ... Automated Border Control (ABC) eGates and 1436 Automated ... than 163 ports of entry across the globe. ... a combined CAGR of 37%. APC Kiosks reached ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... 22, 2017 Scientists propose in Nature ... damage in Gaucher and maybe other lysosomal storage diseases ... costs than current therapies. An international research ... , which also included investigators from the University of ... data Feb. 22. The study was conducted in mouse ...
(Date:2/22/2017)... -- Dublin - Research and ... Protection (Bio-Pesticide) Market-By Type, By Application, By End User, By Region, ... ... Crop Protection Market is forecasted to grow at a CAGR of ... or biological crop protection market is driven by the surging demand ...
(Date:2/22/2017)... DIEGO , Feb. 22, 2017  Creative ... expansion of its translational research program using its ... of laboratory facilities in San Diego.  The Company ... BioLabs facility, a biotechnology incubator sponsored by the ... In November 2016, the Company obtained an ...
(Date:2/21/2017)... ... February 21, 2017 , ... Vortex Biosciences announced ... automated benchtop system for collecting intact circulating tumor cells (CTCs) that are shed ... Medicine Tri Conference (Tri-Con) Annual Meeting 2017 (February 19–24 San Francisco). , The ...
Breaking Biology Technology: