Navigation Links
Is DNA repair a substitute for sex?
Date:4/2/2008

Birds and bees may do it, but the microscopic animals called bdelloid rotifers seem to get along just fine without sex, thank you. Whats more, they have done so over millions of years of evolution, resulting in at least 370 species. These hardy creatures somehow escape the usual drawback of asexuality extinction and the MBLs David Mark Welch, Matthew Meselson, and their colleagues are finding out how.

In two related papers published this week in Proceedings of the National Academy of Sciences (PNAS), the team proposes an interesting hypothesis: Bdelloid rotifers have been able to give up sex and survive because they have evolved an extraordinary efficient mechanism for repairing harmful mutations to their DNA.

We think, in the bdelloid rotifer, genomic changes together with environmental changes have conspired to create something that is able to exist in the absence of sex, says Mark Welch, an assistant scientist in the MBLs Josephine Bay Paul Center.

Their results have medical implications, because DNA repair capacity is an important factor in cancer, inflammation, aging, and other human conditions.

In animals that do have sex, DNA repair is accomplished during meiosis, when chromosomes pair up (one from the father, one from the mother) and fit genes on one chromosome can serve as templates to repair damaged genes on the other chromosome. The bdelloid, though, always seems to reproduce asexually, by making a clone of itself. How then, does it cope with deleterious mutations?

In the first PNAS paper, MBL adjunct scientist Matthew Meselson and Eugene Gladyshev, both of Harvard University, demonstrate the enormous DNA repair capacity of bdelloid rotifers by zapping them with ionizing radiation (gamma rays), which has the effect of shattering its DNA into many pieces. We kept exposing them to more and more radiation, and they didnt die and they didnt die and they didnt die, says Mark Welch. Even at five times
'/>"/>

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Wildcat Power Cord repairs cruciate ligament in dairy cows knee
2. Researchers probe a DNA repair enzyme
3. Building the future -- 21st century nano tools to repair the nervous system
4. Yale receives $8.4 million to study DNA repair in cancer cells
5. Enhanced DNA-repair mechanism can cause breast cancer
6. Using nanotubes to detect and repair cracks in aircraft wings, other structures
7. Simulation reveals how body repairs balance after damage
8. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
9. Enzyme alerts cells powerful army to repair DNA damage
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. Human derived stem cells can repair rat hearts damaged by heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Is DNA repair a substitute for sex?
(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
(Date:4/23/2014)... manufacturers are turning away from using triclosan as an ... health concerns. And now scientists are reporting new evidence ... in the ACS journal Chemical Research in Toxicology ... substance called octylphenol, promoted the growth of human breast ... in mice. , Kyung-Chul Choi and colleagues note that ...
(Date:4/23/2014)... to date of the family of bacteria that ... strategies and reveals surprising findings about the bacteria,s ... public health strategies to control this respiratory disease, ... Genomic analysis of 343 strains of the ... collected over the last 100 years illustrates how ...
Breaking Biology News(10 mins):Genetics risk, prenatal smoking may predict behavioral problems 2In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2Impact of whooping cough vaccination revealed 2
... researcher, please contact the Communications and External Relations staff member ... on ORNL and its research and development activities, please refer ... general media-related question or comment, you can send it to ... fuel pellets . . . Oak Ridge ...
... Spain: The numbers of cycles of preimplantation genetic diagnosis ... 2,700 reported in 2004 (the most recent year for ... screen for a growing number of genetically related conditions, ... the targeted condition are available for transfer and the ...
... that gladdens a mother,s heart also lights up the reward ... in a report that appears in the journal Pediatrics ... out the special mother-infant bond and how it sometimes go ... BCM and Texas Children,s Hospital and a research associate in ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2008 3Should embryos with a hereditary disorder be transferred if no unaffected embryos are available? 2Should embryos with a hereditary disorder be transferred if no unaffected embryos are available? 3A baby's smile is a natural high 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 The Pittcon Organizing ... of Food Safety Tech , an e-Journal and producer ... an agreement for the second year for the co-location of ... 2014. The partnership provides that the registration fee to attend ...
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
(Date:1/15/2014)... Canada (PRWEB) January 15, 2014 This ... on nonclinical and clinical safety assessment in biosimilars. , ... path for biosimilar drug development, however the complex nature ... to quality, safety and efficacy extremely challenging. Based on ...
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... On Thursday, December 9th, Mediaplanet published ... spearheading an industry-wide call to action advocating consumer ... us confront society,s most pressing challenges. By teaming ... Mediaplanet ,s ,Biotechnology, encourages appropriate policy action and ...
... China-Biotics, Inc. ("China-Biotics" or "the Company"), (Nasdaq: ... probiotics products in China, today announced that it has ... promissory notes for cash two days before the December ... notes were originally issued on December 11, 2007. The ...
... 8, 2010 Martek Biosciences Corporation (Nasdaq: MATK ... and fiscal year ended October 31, 2010. Total revenues for ... fourth quarter of fiscal 2009. Fourth quarter non-GAAP earnings per ... diluted share in last year,s fourth quarter.  For the full ...
Cached Biology Technology:The Biotechnology Industry Organization and Critical Path Institute Partner With Mediaplanet, Biocom, and the University of California Office to Spotlight the Science That Is Healing, Fueling and Feeding Our Global Population 2China-Biotics Announces Redemption of $25 million in Senior Convertible Notes 2China-Biotics Announces Redemption of $25 million in Senior Convertible Notes 3Martek Announces Fourth Quarter and FY 2010 Financial Results 2Martek Announces Fourth Quarter and FY 2010 Financial Results 3Martek Announces Fourth Quarter and FY 2010 Financial Results 4Martek Announces Fourth Quarter and FY 2010 Financial Results 5Martek Announces Fourth Quarter and FY 2010 Financial Results 6Martek Announces Fourth Quarter and FY 2010 Financial Results 7Martek Announces Fourth Quarter and FY 2010 Financial Results 8Martek Announces Fourth Quarter and FY 2010 Financial Results 9Martek Announces Fourth Quarter and FY 2010 Financial Results 10Martek Announces Fourth Quarter and FY 2010 Financial Results 11Martek Announces Fourth Quarter and FY 2010 Financial Results 12
... photographic filter (S37100, Photographic Filters for ... ideal for black-and-white photography of gels ... gel stain, the safer ethidium bromide ... photographic filter is identical to the ...
The Zymo-Spin PI Fast-Spin column features durable polypropylene construction and is the same column featured in the His-Spin Protein Miniprep. Capacity is 800 l....
Enodgenous alkaline phosphotase inhibitor. Levamisole solution is supplied in concentrated form (20x). The final concentration of levamisole in the substrate solution will be 1 mM....
LAL Chromogenic Endpoint assay...
Biology Products: