Navigation Links
Irritating smells alert special cells, NIH-funded study finds
Date:3/3/2008

p>This elegant research corrects an erroneous assumption about how irritating odors are perceived and expands our understanding of olfaction, says James F. Battey, M.D., Ph.D., director of NIDCD. With further investigation, it also might lead to a better understanding of why some people are exceptionally sensitive to irritating odors.

Solitary chemosensory cells on the surface of the nasal cavity are in close contact with trigeminal nerve fibers which end just below the surface. Earlier research revealed that these cells contain bitter taste receptors and that bitter substances applied to the surface of the nasal cavity trigger a trigeminal nerve response.

Intrigued, Drs. Restrepo and Finger decided to explore whether solitary chemosensory cells respond to irritating odors. Using nasal tissue from mice, the scientists measured a variety of changes in solitary chemosensory cells as they exposed the cells to low and high levels of several irritating, volatile chemical odors.

Among their observations were changes in electrical activity in the cellswhich indicates a response to an outside stimulusand changes in intracellular calcium ion concentrationwhich indicates signaling to other cells. Their measurements demonstrated that the solitary chemosensory cells responded to the odors and relayed sensory information to trigeminal nerve fibers.

Once stimulated, the trigeminal nerve will convey pain and burning sensations and can trigger protective reflexes such as gagging and coughing. The architecture of nasal tissue with solitary chemosensory cells on the surface and trigeminal nerve fibers just below allows the nose to detect a greater number of irritating odors, the scientists explain.

Fortunately, the threshold for triggering a response is high, so exposure to a small amount of an irritating chemical, as might naturally emanate from some kinds of fresh fruit, will not bring on gagging and coughing. For example, lemons conta
'/>"/>

Contact: Linda Joy
ljoy@mail.nih.gov
301-496-7243
NIH/National Institute on Deafness and Other Communication Disorders
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gene determines whether male body odor smells pleasant
2. Telemedicine: Health alert via satellite
3. Alcohol and sleep restriction can affect young mens alertness and driving performance
4. Enzyme alerts cells powerful army to repair DNA damage
5. Corporate Safe Specialists Smart Safes Capture Evidence in Robbery and Theft
6. Weird water: Discovery challenges long-held beliefs about waters special properties
7. World-leading journal publishes special issue on UN/GA
8. Corporate Safe Specialists Announces Addition to Sales Team
9. A special issue of the International Journal of Plant Sciences
10. K-State specialist in tick-borne pathogens receives $1.8 million grant
11. Corporate Safe Specialists Announces Additions to R&D Team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased emphasis ... investments in new testing and inspection technologies. The ... rise to a range of innovative test solutions. ... of Generation Y, which is generally more inclined ... result, product development strategies of test equipment vendors ...
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a ... announced that its DigitalPersona ® Pro Enterprise ... have been deployed throughout First Bank branch locations ... South Carolina and Virginia. First Bank, ... Southern Pines, North Carolina , selected ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... discovered the world,s deepest undersea volcanic vents, known as ... Cayman Trough in the Caribbean. Using a deep-diving ... Cook, the scientists found slender spires made of copper ... enough to melt lead, nearly half a mile deeper ...
... Mass. Using a sensor that weighs cells with unprecedented ... which single cells accumulate mass a feat that could ... those controls fail in cancer cells. The research team, ... revealed that individual cells vary greatly in their growth rates, ...
... (BRONX, NY) In a step towards a possible ... of Medicine of Yeshiva University have shown for the ... may explain damaging cellular behavior in Huntington,s disease. Their ... of Nature Neuroscience . Huntington,s disease, which ...
Cached Biology News:British scientific expedition discovers world's deepest known undersea volcanic vents 2British scientific expedition discovers world's deepest known undersea volcanic vents 3MIT: New cell measurement system 2Faulty clean-up process may be key event in Huntington's disease 2
(Date:12/24/2014)... Dec. 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... on December 22, 2014, thereby completing the U.S. ... the acquisition of the Company by Merck KGaA, ... satisfies another condition to closing the transaction, which ...
(Date:12/22/2014)... , Dec. 22, 2014   ... a developer of pathogen-specific therapies for serious ... protecting the microbiome, today announced positive topline ... 1a clinical trial of SYN-004, the Company,s ... of Clostridium difficile (C. difficile) ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/19/2014)... Tigard, OR and Hershey, PA (PRWEB) December 19, ... (OTC Pink: BJCT), a leading developer and manufacturer ... has entered into an agreement with Immunomic Therapeutics, ... Bioject’s Biojector®-2000 needle-free injection device with its LAMP™ ... receives an option for an exclusive Worldwide license ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... developing new sensors to detect chemical agents and illegal drugs ... terrorist attacks. The devices will use special gel pads ... sample which is then analysed by a scanning instrument that ... allow better, faster decisions to be made in response to ...
... , , NEW YORK, ... research report is available in its catalogue: , ... http://www.reportlinker.com/p0170008/Infectious-Disease-Molecular-Diagnostic-Testing.html , The report ... needs for major infectious diseases, as well as extensive ...
... , , , , ... novel stem cell based,technology of Cellonis Biotechnologies, Beijing, a Chinese ... a 36 year old Norwegian,patient in a hospital in Beijing. ... tumor stem cells as well as cancer daughter,cells. The amazing ...
Cached Biology Technology:New technology detects chemical weapons in seconds 2Reportlinker Adds Infectious Disease Molecular Diagnostic Testing 2For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 2For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 3For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 4
Human RUNX2/CBFA1 MAb (Clone 232902)...
Lipid-rich bovine serum albumin for cell culture (1). It is chromatographically purified and has an IgG content 0.1% (w/w)....
normal rat IgM AF647...
GlutaMAX-I Supplement...
Biology Products: