Navigation Links
Irritable bowel syndrome can have genetic causes
Date:12/10/2008

Irritations of the bowel can have genetic causes. Researchers at the Institute of Human Genetics at Heidelberg University Hospital have discovered this correlation. The causes of what is known as irritable bowel syndrome (IBS), one of the most common disorders of the gastrointestinal tract, are considered unclear making diagnosis and treatment extremely difficult. The results from Heidelberg, which were published in the prestigious jour-nal "Human Molecular Genetics", improve the outlook for an effective medication against a disease that is frequently played down as a func-tional disorder.

In Germany, approximately five million people are affected by IBS, women about twice as often as men. But only around 20 percent of these people even consult a physician. Many patients suffer from constipation, others from severe diarrhea, or a combination of both. The illness affects the general condition and quality of life of these patients and often lasts for months or even years.

Modified receptors lead to overstimulation of the bowel

Serotonin plays an important role in the complex processes in the diges-tive tract just as it affects sleep, mood, and blood pressure. Various types of receptors are located in the intestine, to which serotonin attaches according to the lock and key principle and thus transmits cellular signals.

"We have determined that patients who suffer from irritable bowel syn-drome with diarrhea show a higher frequency of certain mutations ", ex-plains Dr. Beate Niesler, who investigates the genetic causes of complex diseases with her team in the Department of Human Molecular Genetics (Director: Prof. Gudrun Rappold) at the Heidelberg Institute of Human Genetics. These mutations appear to cause changes in the composition or number of receptors on the cell surface. "The signal transduction in the digestive tract may be disturbed and this may lead to overstimulation of the intestine. Resulting dist
'/>"/>

Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
0049-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Is yakult helpful in the treatment of irritable bowel syndrome?
2. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
3. Scientists successfully treat new mouse model of inflammatory bowel disease
4. New genes found for inflammatory bowel disease in children
5. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
6. Researchers identify proteins involved in new neurodegenerative syndrome
7. Restless legs syndrome affects nearly 2 percent of US/UK children
8. Obesity-related hormone is higher in children with Down syndrome
9. Rare cancer-causing syndrome found, for the first time, in Singapore
10. Effective ADHD treatment found for children with fragile X syndrome
11. Study suggests new way to screen infants for fetal alcohol syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... of yellow-shouldered bats have been unearthed by scientists at the American ... and described in the open access journal ZooKeys ... are part of a recent discovery of three bats hidden away ... be officially announced. , Up until recently the genus Sturnira ...
(Date:4/16/2014)... you cannot lift your upper eyelid. You walk through life with ... they are rolled down in the eye socket. Obviously, such a ... their head. In order to correct this condition, one would need ... the April 16 print issue of the journal Neuron , ...
(Date:4/16/2014)... - Geoscientists from the north-central U.S. and beyond will ... discuss new science, expand on existing science, and explore ... with a special emphasis on applied geology, paleontology, and ... p.m. on Thursday by Dr. Kirk Johnson, Sant Director ...
Breaking Biology News(10 mins):Two new species of yellow-shouldered bats endemic to the Neotropics 2Researchers track down cause of eye mobility disorder 2Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4
... study shows how competition among the human immune system's ... eventually develop into full-blown AIDS. The study, which employs ... evolution, also suggests a new strategy for vaccinating against ... may prevent the final onset of AIDS. , The ...
... and efficient strategy, using eggs alone, for creating mouse ... risk of rejection because the cells are compatible with ... online in the journal Science on December 14. , ... of using unfertilized eggs as a source of customized ...
... a boy is hardwired into fruit fly neurons, according to ... publication by a research team from Harvard Medical School and ... that a gene known as "fruitless" is a key factor ... in an unlikely new animal model for understanding the biology ...
Cached Biology News:HIV exploits competition among T-cells 2HIV exploits competition among T-cells 3Researchers create genetically matched embryonic stem cells for transplantation 2Researchers create genetically matched embryonic stem cells for transplantation 3Fighting like a girl or boy determined by gene in fruit flies 2Fighting like a girl or boy determined by gene in fruit flies 3
(Date:1/15/2014)... January 15, 2014 Look inside the ... items for the lab, from fluid handling to instruments ... to ship when you order. , Preferred Solutions ... , from the L/S® model for precise flow control ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... , , , BANGALORE, India ... by Their Side, This Case Challenged Medical Excellence , ... Wockhardt Hospitals, Bangalore (Now a Network Hospital of Fortis),has performed a ... Brendan was suffering from congenital heart defect called - Tetralogy of,Fallot or ...
... ... endovascular therapy. Two years after endovascular treatment, 88 percent of women avoided amputation compared ... ... who are at risk of lower-leg amputation fare even better than men when they have ...
... (BNNTs) are the divas of the nanoworld. In possession ... to their carbon-based cousins. On the plus side, ... degrees Celsius, says Yoke Khin Yap, an associate professor ... burn like charcoal in a barbecue at half of ...
Cached Biology Technology:2-Year-old Baby With Complex Heart Deformity Undergoes Major Open Heart Surgery at Wockhardt Hospitals, Bangalore - (now a Network Hospital of Fortis) Without any Blood Transfusion 22-Year-old Baby With Complex Heart Deformity Undergoes Major Open Heart Surgery at Wockhardt Hospitals, Bangalore - (now a Network Hospital of Fortis) Without any Blood Transfusion 3Women More Likely Than Men to Avoid Amputation After Minimally Invasive Therapy for Blocked Leg Arteries 2Women More Likely Than Men to Avoid Amputation After Minimally Invasive Therapy for Blocked Leg Arteries 3Harnessing the divas of the nanoworld 2
... HT is taking automated patch clamping to a ... ability to generate thousands of high quality data ... paradigms in ion channel drug discovery and safety ... quality afforded by conventional patch clamping can now ...
... mouse embryonic stem cells to dopaminergic neurons. ... where they are mainly located in the ... the retrorubral field. These dopaminergic (DA) neurons ... ( e.g.projections to the caudate nucleus, putamen ...
... RNA aptamer screening and binding optimization and ... microfluidic on-chip synthesis platform. Thousands of customer ... and LC Sciences can provide assistance with ... as part of our comprehensive DNA/RNA Aptamer ...
... synthetic peptide whose sequence is from the C-terminal end of the mouse ... from amino acids 429 to 448 of RAR*. The sequence of ... V - S - P - S - S - V - ... Q - S - P - L - L - Q ...
Biology Products: