Navigation Links
Irritable bowel syndrome can have genetic causes
Date:12/10/2008

Irritations of the bowel can have genetic causes. Researchers at the Institute of Human Genetics at Heidelberg University Hospital have discovered this correlation. The causes of what is known as irritable bowel syndrome (IBS), one of the most common disorders of the gastrointestinal tract, are considered unclear making diagnosis and treatment extremely difficult. The results from Heidelberg, which were published in the prestigious jour-nal "Human Molecular Genetics", improve the outlook for an effective medication against a disease that is frequently played down as a func-tional disorder.

In Germany, approximately five million people are affected by IBS, women about twice as often as men. But only around 20 percent of these people even consult a physician. Many patients suffer from constipation, others from severe diarrhea, or a combination of both. The illness affects the general condition and quality of life of these patients and often lasts for months or even years.

Modified receptors lead to overstimulation of the bowel

Serotonin plays an important role in the complex processes in the diges-tive tract just as it affects sleep, mood, and blood pressure. Various types of receptors are located in the intestine, to which serotonin attaches according to the lock and key principle and thus transmits cellular signals.

"We have determined that patients who suffer from irritable bowel syn-drome with diarrhea show a higher frequency of certain mutations ", ex-plains Dr. Beate Niesler, who investigates the genetic causes of complex diseases with her team in the Department of Human Molecular Genetics (Director: Prof. Gudrun Rappold) at the Heidelberg Institute of Human Genetics. These mutations appear to cause changes in the composition or number of receptors on the cell surface. "The signal transduction in the digestive tract may be disturbed and this may lead to overstimulation of the intestine. Resulting dist
'/>"/>

Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
0049-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Is yakult helpful in the treatment of irritable bowel syndrome?
2. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
3. Scientists successfully treat new mouse model of inflammatory bowel disease
4. New genes found for inflammatory bowel disease in children
5. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
6. Researchers identify proteins involved in new neurodegenerative syndrome
7. Restless legs syndrome affects nearly 2 percent of US/UK children
8. Obesity-related hormone is higher in children with Down syndrome
9. Rare cancer-causing syndrome found, for the first time, in Singapore
10. Effective ADHD treatment found for children with fragile X syndrome
11. Study suggests new way to screen infants for fetal alcohol syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... especially the young, are highly sensitive to temperature and ... temperatures within a narrow range. Recently published research led ... School of Arts and Sciences, is the first to ... hive in process similar to how humans and other ... , "This study shows how workers effectively dissipate ...
(Date:7/23/2014)... analysis of Antarctic fur seals, alongside decades of ... effect of climate change on a population of ... the findings show that the seals have significantly ... that are associated with climate conditions. Despite a ... fitness is not passing down through generations, leaving ...
(Date:7/23/2014)... samples cultured from cystic fibrosis patients, scientists at the ... Institute have shown that a new CF drug counteracts ... , The finding, published today in the journal ... protein becomes unstable and loses its ability to function ... The research offers several insights into how novel CF ...
Breaking Biology News(10 mins):How honey bees stay cool 2Genetic study shows major impact of climate change on Antarctic fur seals 2Genetic study shows major impact of climate change on Antarctic fur seals 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 4
... Whitehead Institute scientists report that the gene mutated ... syndrome also prevents activation of mTORC1, a critical nutrient-sensing ... is an unexpected finding, as some cancers keep this ... expansion. In the case of Birt-Hogg-Dub syndrome, the mutated ...
... of ZooKeys - no. 346 ... on its day of publication last Friday. This marks ... taxonomic names for animals. The innovative workflow was jointly ... and a U.S. National Science Foundation project to ...
... The Prime Minister of Malaysia today outlined his country,s ... development goals, saying they need to address the relief ... concerns. Prime Minister Najib Razak commended the Millennium ... eight objectives agreed by nations in 2000 for completion ...
Cached Biology News:Gene responsible for hereditary cancer syndrome found to disrupt critical growth-regulating pathway 2Next-generation global e-infrastructure for taxon names registry 2As world sets new development goals, Malaysia calls for poverty relief within green agenda 2As world sets new development goals, Malaysia calls for poverty relief within green agenda 3As world sets new development goals, Malaysia calls for poverty relief within green agenda 4
(Date:7/23/2014)... (PRWEB) July 23, 2014 a2z Inc. ... ChirpE Mobile App, AACC Pathfinder, in its 2014 ... AACC’s annual meeting is planned for July 29-31, 2014 ... place to be to connect with global leaders in ... management, and other areas of breaking science in laboratory ...
(Date:7/22/2014)... phylum so full of mean little creatures, the yellow-colored Ormia ... -- at least to crickets. Native to the southeastern U.S. ... sort of parasite. It swoops onto the back of a ... its wicked brood to invade, kill and consume the cricket ... possible without the fly,s ability to find a cricket -- ...
(Date:7/22/2014)... New York (PRWEB) July 22, 2014 ... world. The heat produced by controlled fission chain reaction ... This steam pressure is used to drive a power- ... approximately 19% of the world’s total electricity production. Nuclear ... to several under construction, planned and proposed nuclear reactor ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Two new ... Board of Directors at its annual Shareholders Meeting on ... Information Officer of The PFM Group, and Stephen T. ... Center also announced the election of Michael A. DiPiano, ... Vice Chair and Richard P. Jaffe, Esq., of Duane ...
Breaking Biology Technology:AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 3Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 2Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 3Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3
... and Advice Shared Through Dynamic WikiAnswers Q&A ... ... In a show of support for National,Breast Cancer Awareness Month, Answers.com,s ... http://wiki.answers.com/Q/FAQ/2375 ), where breast cancer survivors,friends and family have gathered to ...
... NEW YORK, Oct. 22 SPO Medical Inc. ... microprocessor,technologies for use in portable monitoring devices, today announced ... sales milestone has,been achieved within three years of the ... of the 100,000 units sold include the patented technology ...
... Pharmacopeia,(Nasdaq: PCOP ), an innovator in the discovery ... Dr. Leslie J. Browne,President and Chief Executive Officer, will ... Renshaw 9th Annual Healthcare,Conference. The conference will be held ... Hotel in New York City. Dr. Browne,s presentation ...
Cached Biology Technology:Answers.com's WikiAnswers Supervisors Rallying for National Breast Cancer Awareness Month 2Answers.com's WikiAnswers Supervisors Rallying for National Breast Cancer Awareness Month 3SPO Medical Announces Major Sales Milestone 2SPO Medical Announces Major Sales Milestone 3Pharmacopeia to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 2Pharmacopeia to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 3Pharmacopeia to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 4
... Synucleins are small, soluble proteins expressed ... tumors. The family includes three known proteins: ... The alpha and beta synuclein proteins are ... are seen mainly in presynaptic terminals. ...
NAK/TBK1 (CT) Affinity Purified Polyclonal Antibody...
This adapter allows the Thermo-Fast® 96 Semi-Skirted (AB-0900 and AB-0990) PCR plates to be used directly in the ABI PRISM® 3100 sequencer without the need for software changes....
... Finnpipette BioControl multichannel has ... as the single channel ... fits allseven multichannel and ... cone modules. Both pipettes ...
Biology Products: