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Iron-moving malfunction may underlie neurodegenerative diseases, aging
Date:9/22/2008

the cell is going to suffer." Indeed, abnormal accumulation of lipofuscin is associated with a range of disorders including Alzheimer's disease, Parkinson's disease, and macular degeneration (a degenerative disease of the eye) and also contributes to the aging process.

"In a sense we can think of ML4 as really early onset of aging," Xu said.

Now that the connections among TRPML1, iron and lipofuscin are coming into focus, researchers have new avenues to explore for potential treatments, not only for ML4 but also for more common neurodegenerative conditions.

"If we can somehow manipulate the lysosome iron level, we probably can provide a treatment for the patient," Xu said. "We're not far enough along for those kinds of experiments yet, but now we know enough to work toward that goal."


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Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

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