Navigation Links
Iron-moving malfunction may underlie neurodegenerative diseases, aging
Date:9/22/2008

ANN ARBOR, Mich.---A glitch in the ability to move iron around in cells may underlie a disease known as Type IV mucolipidosis (ML4) and the suite of symptoms---mental retardation, poor vision and diminished motor abilities---that accompany it, new research at the University of Michigan shows.

The same deficit also may be involved in aging and neurodegenerative diseases such as Alzheimer's and Parkinson's, says lead author Haoxing Xu, an assistant professor of molecular, cellular and developmental biology.

The findings are scheduled to be published online Sept. 14 in the journal Nature.

An interest in iron transport led Xu to investigate ML4, another symptom of which is iron-deficiency anemia. Perhaps, he and his collaborators reasoned, impaired iron transport could explain both the anemia and the other problems that go hand-in-hand with ML4, a genetic disorder that mainly affects Jews of Eastern European background. Children with ML4 begin showing signs of developmental delay and eye problems during the first year of life and typically fail to progress beyond the level of a 15-month-old. Although the disease is rare, recent discovery of some children with milder forms of the condition raises the possibility of additional mild, undiagnosed cases.

To explore the possible role of iron transport in the disease, Xu's group focused on a protein called TRPML1. A mutation in the gene that produces TRPML1 is known to cause ML4, so the protein seemed like a logical starting point for investigating mechanisms responsible for the disease, even though TRPML1 had never been shown to be involved in iron transport. The only protein with that distinction was DMT1, which facilitates iron uptake in the gut and in cells that will become red blood cells, but not in most other cell types.

"Essentially all cells, including nerve cells and muscle cells, need iron," Xu said. "We wondered what happens in those cells where DMT1 isn
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Complex dynamics underlie bark beetle eruptions
2. Antioxidant overload may underlie a heritable human disease
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. Gene therapy slows progression of fatal neurodegenerative disease in children
5. The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
6. Researchers identify proteins involved in new neurodegenerative syndrome
7. Certain diseases, birth defects may be linked to failure of protein recycling system
8. New chimeric mouse model for human liver diseases, drug testing
9. Syntermed licenses Emory ERTb software for enhanced cardiac imaging
10. Old before their time? Aging in flies under natural vs. laboratory conditions
11. Scientists use remote satellite imaging to predict outbreaks of infectious disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/18/2014)... 18, 2014  The Secure Identity & Biometrics ... jointly announce the formation of The Airport Entry ... Identity and Biometric Entry and Exit Solutions ... official support from BORDERPOL, the international non-profit organization ... provide expertise regarding border security, traveler and migration ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... WASHINGTON, D.C. (March 6, 2011) -- New findings from researchers ... Sick Children in Toronto may shed light on the mechanisms ... a critical aspect of cell signaling not well understood at ... of the macrophage protein CD36, a clustering-responsive class B scavenger ...
... MARCH 4, 2011 North and South Carolina have seen ... years. In North Carolina alone, swine production generates approximately a ... so many large-scale pig farms leads to the problem of ... the Carolinas is storing animal waste in anaerobic lagoons. They ...
... of Engineering researcher is seeking a new way to ... their voice. But this isn,t "The King,s Speech," the ... therapy to battle a stammer. Instead, Alexander Leonessa ( ... of stroke patients and others who have suffered paralysis ...
Cached Biology News:Environmental impact of animal waste 2Virginia Tech researcher seeks to use electrical stimulation to give voice to stroke patients 2Virginia Tech researcher seeks to use electrical stimulation to give voice to stroke patients 3
(Date:12/24/2014)... “Preparative & Process Chromatography Market by ... Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, End ... to 2019” provides a detailed overview of the ... and strategies impacting the preparative and process chromatography ... the revenue and share analysis. , Full ...
(Date:12/24/2014)... On Friday, December 19, 2014, President ... and Continuing Resolution Appropriations Act of 2015, which ... eligible to receive funding through the Congressionally Directed ... of Defense (DoD). The Hydrocephalus Association (HA), working ... is celebrating this victory for the over 1 ...
(Date:12/24/2014)... 2014 The report expects global cell ... 2019. It also provides a carefully analyzed data about ... for the market. , Full Copy of Report @ ... global market for cell expansion will keep witnessing growth ... this growth to be driven by rapid technological advancements, ...
(Date:12/24/2014)... PharmaBoardroom,s new report, , ... available for free download , digs deep into this ... in the sector today. One area where ... in developing a homegrown pharmaceutical manufacturing base, even if the ... some way off. A cursory comparison with neighboring ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... California taxpayer and consumer rights group believes the U.S. ... the Wisconsin Alumni Research Foundation regarding its ... foundation said its recent $1 million jury reward in ... patents. , ,Representatives of the Foundation for Taxpayer ...
... Jim Doyle has signed into law Senate Bill 338, ... obstacles that stand in the way of University of ... researchers more quickly turn research ideas into potential business ... review whenever UW faculty and staff try to start ...
... capitalist in San Francisco or Boston, and youre on the verge ... Everything looks right: The management team is in place, the business ... ,But then a lawyer steps into the room, clears her throat ... law. Better not write that check, she says, until you learn ...
Cached Biology Technology:California group says ruling weakens WARF's stem cell patent 2California group says ruling weakens WARF's stem cell patent 3California group says ruling weakens WARF's stem cell patent 4Why repealing the shareholder wage lien law makes sense 2Why repealing the shareholder wage lien law makes sense 3
ANTI-HUMAN CYTOKINES, GROWTH FACTORS (polyclonal rabbit (or goat) antibodies) Human TARC - Biotin...
Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swi...
Anti-Mouse IgM Heavy Chain:FITC, Clone LO-MM-9, Monoclonal Antibody...
Rabbit polyclonal to FOXJ2 ( Abpromise for all tested applications). entrezGeneID: 55810 SwissProtID: Q9P0K8...
Biology Products: