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Ireland Cancer Center researchers advance stem cell gene therapy
Date:12/12/2007

A-MGMT gene.

In addition to this promising research, Ireland Cancer Center scientists presented 24 oral and poster presentations at ASH. The breadth and depth of this innovative hematologic research at the Ireland Cancer Center are outstanding, says Alvin Schmaier, MD, Chief of Hematology/Oncology at UHCMC and Case Western Reserve University School of Medicine. Our faculty is making tremendous advances in these fields which is reflected in their being chosen for oral and poster presentations.

The presentations include:

  • Dr. Hillard Lazarus and colleagues presented significant findings that treatment with Rituximab before transplantation results in cure rate and overall survival in patients undergoing autologous stem cell transplantation for Diffuse Large B-Cell lymphoma.

  • Dr. Lazarus and colleagues of the Eastern Cooperative Oncology Group (ECOG) presented data that show that Imatninib (Gleevec) does not change outcomes on patients with Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia.

  • Dr. Lazarus presented an assessment of data over 30 years regarding acute leukemia and its management. He found that all avenues lead to stem cell transplantations. His team provided this assessment of a whole host of entities that provide leukemia care.

  • Dr. Jonathan Kenyon and colleagues found that normal individuals over age 50 begin to show evidence that genetic mutations are accumulating in marrow stem cells. This finding might be the key underlying the increased risk of anemias, myelodysplastic syndrome and acute leukemia in older individuals.

  • Dr. Kevin Buntings laboratory gave two important presentations on how intracellular STAT5 (an intracellular signaling protein) influences normal pathologic hematopoiesis (blood cell formation) and stem cell engraftment.

  • Dr. Shigemi Matsuyama and colleagues presented a nov
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Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-844-5158
University Hospitals of Cleveland
Source:Eurekalert

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