Navigation Links
Iowa State University researcher uncovers potential key to curing tuberculosis
Date:10/1/2009

AMES, Iowa - Researchers at Iowa State University have identified an enzyme that helps make tuberculosis resistant to a human's natural defense system. Researchers have also found a method to possibly neutralize that enzyme, which may someday lead to a cure for tuberculosis.

Tuberculosis is caused by Mycobacterium tuberculosis and is a contagious disease that is on the rise, killing 1.5 to 2 million people worldwide annually.

Reuben Peters, associate professor in the department of biochemistry, biophysics and molecular biology, is leading the team of scientists from Iowa State; the University of Illinois, Urbana-Champaign; and Cornell University, Ithaca, New York, that is attempting to find ways to minimize the disease. The group had their research published in the Aug. 28 issue of the Journal of Biological Chemistry, and their research is also scheduled to be the cover article in an upcoming issue of the Journal of the American Chemical Society.

When most infections are introduced into humans, the body defends itself with certain cells -- called macrophage cells -- that kill the invading micro-organisms. The macrophage cells engulf and destroy these microbes, such as the Mycobacterium tuberculosis.

Peters found that the mycobacterium tuberculosis produces a defensive molecule that prevents the macrophage cells from destroying them. Peters and his team named the defensive molecule edaxadiene.

Peters' next step was to try to find molecules that bind with the edaxadiene-producing enzymes from tuberculosis and neutralize them. This makes the tuberculosis cells unable to produce edaxadiene. Without edaxadiene, tuberculosis cells would have a reduced ability to resist being killed by the macrophage cells.

Peters thinks he may have already found one.

"We have inhibitors that bind tightly to one of the enzymes that make edaxadiene in a test tube," said Peters.

Finding an in
'/>"/>

Contact: Reuben Peters
rjpeters@iastate.edu
515-294-8580
Iowa State University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Kent State University Professor C. Owen Lovejoy helps unveil oldest hominid skeleton
2. Delaware State U. receives $5 million NASA grant for optics research
3. PyroHands: NC State receives grant to develop next generation firefighter gloves
4. NSF funds states first imaging system for UAB microscale research lab
5. Georgia State researcher to use $1 million grant to improve computer models for fighting wildfires
6. K-State geographer working to clarify what sustainability really means to rural decision-makers
7. Rutgers to collaborate in $3.4 million effort to improve prostate cancer identification using MRI
8. ELISE ID to Power State Driver Registration Search System
9. Aware Software and Development Services Enable State-of-the-Art Fingerprint Card Scanning
10. Scientists find that individuals in vegetative states can learn
11. Cybernetwork to help K-State researchers study tallgrass prairie, respond to global warming
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iowa State University researcher uncovers potential key to curing tuberculosis
(Date:9/29/2014)... Joint Genome Institute (DOE JGI), a DOE Office ... new projects have been selected for the 2015 ... to Caribbean waters, and from plant root micro-ecosystems, ... forested watersheds, the CSP 2015 projects portfolio highlights ... extracted. , "These projects catalyze JGI,s strategic ...
(Date:9/29/2014)... can DNA from the skeleton of a man who lived ... us about ourselves as humans? A great deal when his ... in genetic terms found to-date in a region where ... ago. , The man,s maternal DNA, or ,mitochondrial DNA, ... and evolution. Mitochondrial DNA provided the first evidence that we ...
(Date:9/29/2014)... CHAMPAIGN, Ill. Scientists have discovered a previously ... divide, grow and, in the case of estrogen-positive ... the work reveals new targets for breast cancer ... need the most aggressive treatment. , The University ... journal Oncogene . , Estrogen pre-activates the ...
Breaking Biology News(10 mins):2015 DOE JGI's science portfolio delves deeper into the Earth's data mine 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 32015 DOE JGI's science portfolio delves deeper into the Earth's data mine 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 52015 DOE JGI's science portfolio delves deeper into the Earth's data mine 62015 DOE JGI's science portfolio delves deeper into the Earth's data mine 72015 DOE JGI's science portfolio delves deeper into the Earth's data mine 82015 DOE JGI's science portfolio delves deeper into the Earth's data mine 9Ancient human genome from southern Africa throws light on our origins 2Ancient human genome from southern Africa throws light on our origins 3Scientists discover a new role for estrogen in the pathology of breast cancer 2
... researchers have found that the naturally occurring marine toxin ... in rats exposed to the chemical before birth. Humans ... after eating contaminated shellfish. , The researchers saw ... exposure to domoic acid levels below those generally deemed ...
... (Nasdaq: SLXA) today announced that its researchers in collaboration ... Delaware reported the most comprehensive analysis to date of ... "Elucidation of the Small RNA Component of the Transcriptome," ... the peer-reviewed journal Science. Solexa's assay can be used ...
... Medicine uses PET, radiotracer to track enzyme in smokers, ... in the lungs, possibly contributing to some of smoking's ... the September issue of the Journal of Nuclear Medicine. ... enzyme, also shows that smokers had a lower concentration ...
Cached Biology News:Prenatal exposure to marine toxin causes lasting damage 2Prenatal exposure to marine toxin causes lasting damage 3Solexa and collaborating scientists illuminate the small RNA component of the transcriptome 2Smoking damages key regulatory enzyme in the lung 2Smoking damages key regulatory enzyme in the lung 3
(Date:9/30/2014)... Jersey (PRWEB) September 30, 2014 ... has been chosen by the Parenteral Drug Association ... 18 and 19, 2014) on container closure integrity testing. ... closure integrity test methods and philosophies detailed in the ... Integrity Evaluation. The course will span container ...
(Date:9/29/2014)... start of the military conflicts in Iraq and Afghanistan, ... States with traumatic brain injury caused by exposure to ... explosive devices, or IEDs. Symptoms of traumatic brain injury ... and nausea, to more severe impairments in memory and ... Defense has recognized the critical importance and complexity of ...
(Date:9/29/2014)... Present-day lithium batteries are efficient but involve a ... from alfalfa (lucerne seed) and pine resin and ... come up with a highly interesting alternative. Their ... journal ChemSusChem . , ,We think our ... energy-efficient solutions for the batteries of the future, ...
(Date:9/29/2014)... Mass. , Sept. 29, 2014  Atlas Venture, ... life sciences and technology innovation, today announced that ... Epizyme (NASDAQ: EPZM ), is joining the ... October 1, 2014. At Atlas, Rhodes will ... groundbreaking companies. He brings an accomplished record in company ...
Breaking Biology Technology:Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4Smart, eco-friendly new battery to solve problems 2Atlas Venture Names Jason Rhodes, Veteran Investor and President and CFO of Epizyme, As Partner on Life Sciences Investing Team 2
... Software, a leading provider of image data management tools for ... Open Microscopy Environment Consortium, is proud that its founder Professor ... this year,s BBSRC Innovator of the Year. The BBSRC is ... in the non-clinical life sciences, and along with the Wellcome ...
... the best education and to absorb what they are ... the journal Academic Medicine * connects research on how ... real world education, particularly the education of doctors. "Repetition, ... knowing what is happening in the brain will enhance teaching ...
... surgeon Dr. Lewis Groden presented results from a ... and Refractive Surgery (ASCRS) Symposium revealing that LASIK procedures ... and very high patient satisfaction rates. Each ... vision center currently offers patients a choice of multiple ...
Cached Biology Technology:Glencoe Software and Open Microscopy Environment Founder Awarded the BBSRC Innovator of the Year 2011 2Brain scientists offer medical educators tips on the neurobiology of learning 2Brain scientists offer medical educators tips on the neurobiology of learning 3Brain scientists offer medical educators tips on the neurobiology of learning 4Brain scientists offer medical educators tips on the neurobiology of learning 5LasikPlus® Research Reveals Excellent Results From Modern LASIK 2
Tumor Suppressor Sampler Kit 10 mu g each...
AMAP Multi Site-directed Mutagenesis Kit Research Focus: other Storage Temperature: -20C Shipping Temperature: dry ice...
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Biology Products: