Navigation Links
Iowa State University researcher shows proteins have controlled motions
Date:8/27/2008

AMES, Iowa -- Iowa State University researcher Robert Jernigan believes that his research shows proteins have controlled motions.

Most biochemists traditionally believe proteins have many random, uncontrolled movements.

Research conducted by Jernigan, director of the L.H. Baker Center for Bioinformatics and Biological Statistics together with Guang Song, an assistant professor in computer science and graduate student Lei Yang, over a 10-year period shows that not only are protein motions more restricted, but also that these restricted, controlled motions are part of the function of the proteins.

The group's findings were recently published in the journal "Structure."

Using as an example a protein from HIV virus, Jernigan conducted his research using a simple model and tested to see how the proteins moved. The large number of reported structures show exactly the motions that are required for their function, and exactly the same motions as computed by Jernigan's model.

"This is one experimental case that is indicative, but there are many others," he said.

Jernigan believes this research is the first step to better understanding proteins and cell behaviors.

"There is the possibility of creating designer drugs with this newly discovered information," he said.

"These are models that conform to the point of view that the structures have been designed to exert very strong control of their motions," he said. "Those motions correspond closely to the motions needed for their function."

For instance, HIV virus protein structures that Jernigan studied did not move randomly, but actually opened and closed to allow access to other structures.

There is a binding site that must open to permit access to the protein and then close again to allow the protein to function, he said.

Because the protein structure opens and closes as part of it function, Jernigan believes that the motion is controlled and part of the function of the protein.

Jernigan's studies used the HIV virus, but he believes that the results are relevant to many other protein structures.


'/>"/>

Contact: Robert Jernigan
jernigan@iastate.edu
515-294-3833
Iowa State University
Source:Eurekalert

Related biology news :

1. Rapid test for pathogens developed by K-State researchers
2. Why a common treatment for prostate cancer ultimately fails
3. Sweets make young horses harder to train in Montana State study
4. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
5. Costs of climate change, state-by-state: Billions, says UMD
6. NIH awards more than $33 million to fund state-of-the-art research equipment
7. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
8. Prostate cancer vaccines more effective with hormone therapy
9. Iowa State researchers study ground cover to reduce impact of biomass harvest
10. NOAA report states half of US coral reefs in poor or fair condition
11. Counting tumor cells in blood predicts treatment benefit in prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... 30, 2017 Trends, opportunities and forecast in ... by technology (fingerprint, AFIS, iris recognition, facial recognition, hand ... by end use industry (government and law enforcement, commercial ... banking, and others), and by region ( North ... Asia Pacific , and the Rest of ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... 23, 2017 , ... Customers often prefer PLC and ... again. METTLER TOLEDO has released two new videos that show how they have ... the ACT350 into Siemens and Allen Bradley PLCs is easy and fast. ...
(Date:5/21/2017)... ... 20, 2017 , ... CNSDose is a genetically driven, clinically ... by finding the right antidepressant faster. CNSDose speeds recovery and reduces side ... personalized approach to treatment. , A peer-reviewed and published, 12-week double-blind ...
(Date:5/18/2017)... ... May 16, 2017 , ... Clinical Supplies Management (“CSM”), a Great Point ... continues to grow. CSM has doubled in size over the past six months ... growth strategy. , Roger Gasper joins CSM as Chief Financial Officer. Roger has ...
(Date:5/18/2017)... ... May 17, 2017 , ... HOLLOWAY AMERICA, a ... food and dairy, munitions, and pharmaceutical/biotech, recently introduced The Revolution Lift™, a new ... The improvement in technology comes on the heels of HOLLOWAY’s release of the ...
Breaking Biology Technology: