Navigation Links
Iowa State University researcher examines mosquito gene for new disease response
Date:9/30/2010

Ames, Iowa - An Iowa State University researcher searched for new genes that are turned on during infection in a type of mosquito that is not only a pest, but transmits disease-causing pathogens.

Lyric Bartholomay, assistant professor of entomology, along with colleagues from around the world, infected the common southern house mosquito (Culex quinquefasciatus) with various pathogens to see which mosquito genes are activated in response to the infection.

Bartholomay is the first author on the paper, "Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens," to be published in the Oct. 1 issue of the journal Science.

The southern house mosquito is the third of the three most important mosquito disease carriers to have its genome sequenced. The first was an African mosquito (Anopheles gambiae) that transmits malaria parasites. Malaria infects 250 to 500 million people each year and kills nearly one million people annually, mostly young children in sub-Saharan Africa. The second was a tropical mosquito (Aedes aegypti) that carries yellow and dengue fever viruses.

The southern house mosquito is common to many areas of the United States and around the world. It feeds on blood from birds, livestock and humans, and transmits a wide variety of deadly and debilitating human and veterinary pathogens. In addition to transmitting the West Nile virus, the mosquito can carry the St. Louis encephalitis and the microscopic roundworm that causes lymphatic filariasis - a debilitating tropical disease that affects up to 40 million people every year.

Bartholomay participated in cataloging the infection-response genes for Aedes aegypti in a manuscript published in 2007. She was chosen to be first author of the current Science paper because she has experience describing the immune responses in the northern house mosquito (Culex pipiens).

In the research, mosquitoes were infected with viruses, worms and bacteria. The genes of the mosquitoes were monitored to see which changed during the response to infection and therefore could ward off disease.

"What we're trying to do is broaden our understanding of infection response genes beyond those that we expect to be there," said Bartholomay.

"We took a two-pronged approach to understanding infection responses," she added. "First, we scoured the genome sequence looking for those immunity genes that the mosquitoes can use to respond to an infection.

Then, we looked at what genes comprise broad spectrum and specific immune responses.

"We then took it one step further and compared the infection responses in Culex quinquefasciatus to similar infections in Aedes aegypti and Anopheles gambiae."

Bartholomay noted that the functions of many of the genes revealed in this analysis are still unknown, but as more is discovered about the functions of the genes, it could provide the first steps to controlling mosquito-borne diseases.

Bartholomay also worked with colleagues to analyze the mosquito's genome, as reported in a companion paper that will also be published in the current issue of Science.


'/>"/>

Contact: Lyric Bartholomay
lyricb@iastate.edu
515-294-0594
Iowa State University
Source:Eurekalert  

Related biology news :

1. NC State researchers get to root of parasite genome
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. NC State takes lead in crime scene investigation training
4. Penn State receives new NASA astrobiology grant
5. Penn State researcher wins Entomological Society of America award
6. Paradigm Tactical Products to be Largest Distributor of Metal/Radiation Detection Wands in United States
7. Iowa State researcher develops new treatment method for canine eye diseases
8. L-1 Identity Solutions Selected by the State of New York as the Winning Bidder to Provide Enrollment Services for a Contract Estimated at Up to $250 Million
9. State fund advances titanium powder research, 9 other Iowa State projects
10. 15-state Southern obesity summit to focus on deadly epidemic
11. Montana State University researchers find gene that regulates molds resistance to drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iowa State University researcher examines mosquito gene for new disease response
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
Breaking Biology Technology: