Navigation Links
Iowa State University researcher discovers Ebola's deadly secret
Date:1/19/2010

AMES, Iowa - Research at Iowa State University has led scientists to uncover how the deadly Zaire Ebola virus decoys cells and eventually kills them.

A research team led by Gaya Amarasinghe, an assistant professor of biochemistry, biophysics and molecular biology, had previously solved the structure of a critical part of an Ebola protein known as VP35, which is involved in host immune suppression.

Amarasinghe and his research team now know how VP35 is able to do it.

When most viruses invade a cell, they start to make RNA in order to replicate.

When the healthy host cell senses the replicating RNA, the host cell starts to activate anti-viral defenses that halt replication and eventually help clear the viral infections.

What Amarasinghe and his group have discovered is that Ebola virus encoded VP35 protein actually masks the replicating viral ribonucleic acid (RNA), so the cell doesn't recognize that there is an invading virus.

One of the reasons Ebola, in particular the strain isolated from Zaire, is so deadly is that the host cells don't have any immune response when the virus enters the cell, said Amarasinghe.

"The question with Ebola has always been 'Why can't host cells mount an immune response against the Ebola virus, like they do against other viruses?'" he said. ]

"The answer is, 'If the cell doesn't know that there's an infection, it cannot build up any response.' So our work really gets at the mechanism Ebola infection and immune evasion."

The collaborative approach taken by Amarasinghe enabled him to team up with virologist Christopher Basler at the Mt. Sinai School of Medicine, New York City, to investigate how the structural findings match up with how these proteins function inside the cell.

"Our initial structure that we solved in 2008 was key to expanding our knowledge, but the structure was just part of the equation, and when we put it together with the functional studies, everything made sense," A
'/>"/>

Contact: Gaya Amarasinghe
amarasin@iastate.edu
515-294-3216
Iowa State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Obesity and the central nervous system -- the state of the art
2. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
3. Iowa State University conference examines developing bioeconomy
4. University and state agencies to forecast local health effects of climate change
5. K-State Veterinary Lab routinely tests for bluetongue virus
6. New prostate cancer research findings
7. Iowa State professors genome research published in the latest issue of Science
8. Leading researchers to reveal comprehensive dos and donts for prostate cancer
9. K-State chemistry professor to receive Masao Horiba award
10. K-State sociologists use Department of Energy grant
11. NIH grants $33 M in institutional development awards to 3 states
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... have shown for the first time how bacteria can ... giving them the opportunity to get tremendous insights into ... study also discovered the bacterial growth in chronic lung ... slowed down by the immune cells. The researchers discovered ... "suffocate" the bacteria, forcing the bacteria to switch to ...
(Date:10/16/2014)... new synthesis of recent research findings to inform their ... two states. , The Ecology and Management of ... Synthesis of the Relevant Biophysical Science and Implications for ... the U.S. Forest Service,s Pacific Northwest Research Station, is ... a synthesis of the large body of scientific information ...
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... necks and tails, sauropod dinosaurs---famous as the Sinclair gasoline logo ... part because they all seem to look alike. , ... were common in North America during the middle of the ... extinction by more specialized plant-eaters at the end of that ...
... of a female fly is a complicated business of tapping, ... all that is needed to produce this complex behavior, according ... journal Cell. , The gene encodes the Fruitless protein. Male ... as a result of sex-specific splicing of the mRNA. The ...
... prion proteins are little understood disease agents involved in ... people, mad cow disease in cattle and chronic wasting ... that a variant form of abnormal prion protein--one lacking ... signal cells to start the lethal disease process, according ...
Cached Biology News:Skull study sheds light on dinosaur diversity 2Skull study sheds light on dinosaur diversity 3Single gene is genetic switch for fly sexual behavior 2Single gene is genetic switch for fly sexual behavior 3Variant prion protein causes infection but no symptoms 2
(Date:10/22/2014)... 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for its Oral Amphotericin B program.  The company ... vitro work involving samples from HIV/AIDS patients ... complete pre clinical studies and regulatory filings to ... trial, utilizing approximately $700,000 of funding and technological ...
(Date:10/22/2014)... 22, 2014 Research and Markets  has ... by Material, by Application, Geography - Global Analysis and ... Organic electronics, also called as polymer ... science which deals with small conductive molecules and electrically ... molecules and polymers are carbon based, made using synthetic ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Convey ... that a team from Iowa State University won first ... contest. Using a Convey HC-2ex, the team’s solution achieved ... times faster than the second place finisher. , Experts ... embarked upon the month long challenge, using a variety ...
Breaking Biology Technology:iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
... Nov. 30, 2011 iBio, Inc. (NYSE AMEX: IBIO) ... "Plan") to satisfy the requirements for continued listing on the ... Department management (the "Staff") for their review, and that the ... connection therewith.  As previously announced, the Staff indicated that its ...
... --  Quantum Leap Innovations announced today the appointment ... Michael Cusumano is the Sloan Management Review Distinguished Professor ... School of Management, with a joint appointment in the ... STAYING POWER , covers six enduring principles for managing ...
... Calif., Nov. 29, 2011 Molecular Devices, LLC, the ... industry, today announced the release of a much-anticipated customizable ... analysis tools. (Logo:  http://photos.prnewswire.com/prnh/20100406/SF82092LOGO ... will be showcased at the 51st annual meeting of ...
Cached Biology Technology:iBio, Inc. Submits Plan to Satisfy NYSE Amex Continued Listing Standards 2iBio, Inc. Submits Plan to Satisfy NYSE Amex Continued Listing Standards 3Michael Cusumano, MIT's Sloan Distinguished Professor of Management, Joins Quantum Leap Innovations Board of Directors 2Michael Cusumano, MIT's Sloan Distinguished Professor of Management, Joins Quantum Leap Innovations Board of Directors 3Michael Cusumano, MIT's Sloan Distinguished Professor of Management, Joins Quantum Leap Innovations Board of Directors 4Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 2Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 3
... CARV II Confocal Imager delivers high resolution ... use and cost effective optical package that ... multi-point confocal scanning, combined with high quantum ... real-time imaging and recording at up to ...
... EZ DNA Methylation Kit uses a simplified ... DNA methylation analysis. The kit is based ... place between cytosine and sodium bisulfite where ... DNA Methylation Kits innovative in-column desulphonation reaction ...
... Phosphate Assay Kit is based on quantification ... Green, molybdate and free orthophosphate. The rapid ... conveniently measured on a spectrophotometer (600-660 nm) ... colorimetric assay kits have been optimized to ...
... x-ray detectors from KUBTEC represents a stand-alone, ... to 16 bit digital interface. The large ... sensor with pixel spacing down to 48 ... x-ray energies (10-50 kV) and an extended ...
Biology Products: