Navigation Links
Iowa State, Ames Lab researchers find 3 unique cell-to-cell bonds
Date:11/1/2012

AMES, Iowa The human body has more than a trillion cells, most of them connected, cell to neighboring cells.

How, exactly, do those bonds work? What happens when a pulling force is applied to those bonds? How long before they break? Does a better understanding of all those bonds and their responses to force have implications for fighting disease?

Sanjeevi Sivasankar, an Iowa State assistant professor of physics and astronomy and an associate of the U.S. Department of Energy's Ames Laboratory, is leading a research team that's answering those questions as it studies the biomechanics and biophysics of the proteins that bond cells together.

The researchers discovered three types of bonds when they subjected common adhesion proteins (called cadherins) to a pulling force: ideal, catch and slip bonds. The three bonds react differently to that force: ideal bonds aren't affected, catch bonds last longer and slip bonds don't last as long.

The findings have just been published by the online Early Edition of the Proceedings of the National Academy of Sciences.

Sivasankar said ideal bonds the ones that aren't affected by the pulling force had not been seen in any previous experiments. The researchers discovered them as they observed catch bonds transitioning to slip bonds.

"Ideal bonds are like a nanoscale shock absorber," Sivasankar said. "They dampen all the force."

And the others?

"Catch bonds are like a nanoscale seatbelt," he said. "They become stronger when pulled. Slip bonds are more conventional; they weaken and break when tugged."

In addition to Sivasankar, the researchers publishing the discovery are Sabyasachi Rakshit, an Iowa State post-doctoral research associate in physics and astronomy and an Ames Laboratory associate; Kristine Manibog and Omer Shafraz, Iowa State doctoral students in physics and astronomy and Ames Laboratory student associates; and Yu
'/>"/>

Contact: Sanjeevi Sivasankar
sivasank@iastate.edu
515-294-1220
Iowa State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
2. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
3. Researchers use blood testing to predict level of enzymes that facilitate disease progression
4. Researchers identify genetic basis of cardiac, craniofacial birth defects
5. Duke researchers engineer cartilage from pluripotent stem cells
6. NIH researchers identify novel genes that may drive rare, aggressive form of uterine cancer
7. Researchers decipher the mecanism of membrane fission
8. SDSU researchers to study Chinas national treasure
9. Exercise boosts satisfaction with life, researchers find
10. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
11. Far from random, evolution follows a predictable genetic pattern, Princeton researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iowa State, Ames Lab researchers find 3 unique cell-to-cell bonds
(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
(Date:3/24/2015)... WASHINGTON , March 24, 2015   NexID ... applications with critical security-authentication needs, today announced the beginning ... fake-finger-detection (FFD) solution. The company, based in ... announcement at the three-day Connect:ID Expo, which began here ... NexID said version 2.0 of its SDK boosts ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... representatives of the tropical fish known as swordtail characins have ... on a fishing rod would. What,s more, a study reported ... Cell Press publication, shows just what any good fly-fisherman would ... fish most often eat. For some characins in the study, ...
... release is available in German . , It ... defects. This is because the development of the heart in the ... also error-prone. Scientists from the Max Planck Institute for Heart and ... that plays a central role in regulating the function of stem ...
... commonly used to convert chemical energy to electricity is made ... University argues. Rather than continue the futile effort to tweak ... Chemistry Professor Alfred Anderson urges his colleagues to start anew. ... system," he said. Anderson freely acknowledges he doesn,t know what ...
Cached Biology News:Male sex ornaments are fishing lures, literally 2Finished heart switches stem cells off 2Finished heart switches stem cells off 3Platinum is wrong stuff for fuel cells 2
(Date:5/5/2015)... 2015 Research and Markets ( ... "Clinical Laboratory, Molecular Diagnostics and Genomic Testing ... - Europe Version" report to their offering. ... area of molecular diagnostics and pharmacogenics hold the ... market that is moving out of the national ...
(Date:5/5/2015)... College Station, TX (PRWEB) May 05, 2015 ... Pfizer were announced last week as recipients of ... Technology Innovation in recognition of their Portable, Continuous, ... system that integrates a small footprint, continuous processing ... GMP modules) to process API powders and inactive ...
(Date:5/4/2015)... , May 4, 2015 Tobira Therapeutics, ... on the development and commercialization of novel treatments ... completion of its merger with Regado Biosciences, Inc. ... the closing of the merger, Tobira raised $40 ... new investors and all current Tobira institutional investors, ...
(Date:5/4/2015)... N.Y. , May 4, 2015  Traverse ... $250,000 cooperative research and development agreement (CRADA) with ... advance the development of TRB-N0224 for the treatment ... including dogs and cats.  Traverse Biosciences has also ... for the treatment and control of periodontal disease ...
Breaking Biology Technology:European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 2Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 4Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 5Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 6Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 3Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 4
... and Taq DNA Polymerases ,,,, pfuturbo DNA ... amplification , , Holly Hogrefe ... this update, we compare the PCR performances of ... polymerase. ,PCR product yields were higher (>3-kb ...
... Over 145,000 human cDNA clones arrayed for nucleic acid screening , ... de Leon Bruce Jerpseth , ... Stratagene has organized over 145,000 high-quality clones from a universal ... in 29 different human tissues. , This ...
... for Eagle Eye II still video system ... Coomassie ,Brilliant Blue Dye , Michelle Cayouette ... provides an optical bandpass filter with all Eagle,Eye ... visualizing,ethidium bromide fluorescence. However, a single filter specifically designed,for ...
Cached Biology Technology:PCR Performance Comparisons Between pfuturbo and Taq DNA,Polymerases 2PCR Performance Comparisons Between pfuturbo and Taq DNA,Polymerases 3PCR Performance Comparisons Between pfuturbo and Taq DNA,Polymerases 4Human Universal cDNA Library Array I 2Human Universal cDNA Library Array I 3Human Universal cDNA Library Array I 4Human Universal cDNA Library Array I 5Human Universal cDNA Library Array I 6Human Universal cDNA Library Array I 7Optimized Imaging of Protein Gels Stained with Coomassie,Brilliant Blue Dye 2Optimized Imaging of Protein Gels Stained with Coomassie,Brilliant Blue Dye 3Optimized Imaging of Protein Gels Stained with Coomassie,Brilliant Blue Dye 4
... tumor cells of embryonal carcinoma of testis and ... tumors like seminoma. Glandular epithelium of yolk sac ... endocrine cells of stomach and acini cells of ... Epitope: Carbohydrate portion on human embryonal ...
TP-1 (NDOG1)...
Ras-related C3 botulinum toxin substrate 1...
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
Biology Products: