Navigation Links
Iowa State, Ames Lab researchers find 3 unique cell-to-cell bonds
Date:11/1/2012

AMES, Iowa The human body has more than a trillion cells, most of them connected, cell to neighboring cells.

How, exactly, do those bonds work? What happens when a pulling force is applied to those bonds? How long before they break? Does a better understanding of all those bonds and their responses to force have implications for fighting disease?

Sanjeevi Sivasankar, an Iowa State assistant professor of physics and astronomy and an associate of the U.S. Department of Energy's Ames Laboratory, is leading a research team that's answering those questions as it studies the biomechanics and biophysics of the proteins that bond cells together.

The researchers discovered three types of bonds when they subjected common adhesion proteins (called cadherins) to a pulling force: ideal, catch and slip bonds. The three bonds react differently to that force: ideal bonds aren't affected, catch bonds last longer and slip bonds don't last as long.

The findings have just been published by the online Early Edition of the Proceedings of the National Academy of Sciences.

Sivasankar said ideal bonds the ones that aren't affected by the pulling force had not been seen in any previous experiments. The researchers discovered them as they observed catch bonds transitioning to slip bonds.

"Ideal bonds are like a nanoscale shock absorber," Sivasankar said. "They dampen all the force."

And the others?

"Catch bonds are like a nanoscale seatbelt," he said. "They become stronger when pulled. Slip bonds are more conventional; they weaken and break when tugged."

In addition to Sivasankar, the researchers publishing the discovery are Sabyasachi Rakshit, an Iowa State post-doctoral research associate in physics and astronomy and an Ames Laboratory associate; Kristine Manibog and Omer Shafraz, Iowa State doctoral students in physics and astronomy and Ames Laboratory student associates; and Yu
'/>"/>

Contact: Sanjeevi Sivasankar
sivasank@iastate.edu
515-294-1220
Iowa State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
2. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
3. Researchers use blood testing to predict level of enzymes that facilitate disease progression
4. Researchers identify genetic basis of cardiac, craniofacial birth defects
5. Duke researchers engineer cartilage from pluripotent stem cells
6. NIH researchers identify novel genes that may drive rare, aggressive form of uterine cancer
7. Researchers decipher the mecanism of membrane fission
8. SDSU researchers to study Chinas national treasure
9. Exercise boosts satisfaction with life, researchers find
10. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
11. Far from random, evolution follows a predictable genetic pattern, Princeton researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Iowa State, Ames Lab researchers find 3 unique cell-to-cell bonds
(Date:4/23/2014)... 2014) A team of researchers in ... into the brains of nonhuman primates and assessed ... months found that the hNSCs had differentiated into ... tumors. , The study will be published in ... but is currently freely available on-line as an ...
(Date:4/23/2014)... the energy landscape in the U.S., but in ... the energy industry, residents and agricultural interests over ... degraded water quality is a potential risk unless ... in the ACS journal Environmental Science & ... point out that a major criticism of extracting ...
(Date:4/23/2014)... most comprehensive study to date of the family ... more effective vaccine strategies and reveals surprising findings ... results could alter public health strategies to control ... each year. , Genomic analysis of 343 strains ... around the world collected over the last 100 ...
Breaking Biology News(10 mins):Study finds long-term survival of human neural stem cells transplanted into primate brain 2How to avoid water wars between 'fracking' industry and residents 2Impact of whooping cough vaccination revealed 2
... non-human primates, over 100 billion nerve cells build up ... an attempt is made to perform gene therapy for ... specify a responsible neural circuit out of many complicated ... a target gene into this particular circuit selectively. The ...
... has been named founding director of the George Washington ... further strengthen GW,s role as a leader in science ... As director, Dr. Crandall will define the scientific vision ... and implementation of research plans and organizational structures, with ...
... has not changed since the 2010-11 pilot run of the ... University of Arizona-led binational team of researchers. The 15,000-acre ... home to several endangered species and is a major stopover ... It lies within Mexico,s Biosphere Reserve for the Upper Gulf ...
Cached Biology News:Transgenic technique to 'eliminate' a specific neural circuit of the brain in primates 2GW announces creation of Computational Biology Institute to conduct integrated research 2GW announces creation of Computational Biology Institute to conduct integrated research 3GW announces creation of Computational Biology Institute to conduct integrated research 4Cinega de Santa Clara unchanged after pilot run of Yuma Desalting Plant 2Cinega de Santa Clara unchanged after pilot run of Yuma Desalting Plant 3Cinega de Santa Clara unchanged after pilot run of Yuma Desalting Plant 4
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)...  3D Communications, a leading provider of strategic communications services to corporations ... in the United States and ... , JD, is returning to the firm,s Washington, D.C. ... after more than two years of service as Associate Commissioner for ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... Niceware International , a Milwaukee developer of bar ... seen identification software used to track parts in the ... matter of time before healthcare facilities came calling for ... 2002, has produced NiceLabel software for the automatic identification ...
... since the debut of MedTech Futures and it has been ... share ideas with through this forum. As this column enters ... briefly summarize some of the perspectives over the past year ... - namely personalized medicine. , , Medical technology and pharmaceuticals ...
... the state Division of Enterprise Technology is ... recently released audit of state information technology projects. , ... said he concurs with all the recommendations contained in ... executive-level agencies report by Oct. 1 of this year ...
Cached Biology Technology:Software company enters health space with RFID solutions on hold 2Software company enters health space with RFID solutions on hold 3Personalized medicine and technology convergence 2Personalized medicine and technology convergence 3Personalized medicine and technology convergence 4Personalized medicine and technology convergence 5Personalized medicine and technology convergence 6Personalized medicine and technology convergence 7Personalized medicine and technology convergence 8State technology chief endorses IT audit recommendations 2State technology chief endorses IT audit recommendations 3
Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swi...
Anti-Mouse IgM Heavy Chain:FITC, Clone LO-MM-9, Monoclonal Antibody...
Rabbit polyclonal to FOXJ2 ( Abpromise for all tested applications). entrezGeneID: 55810 SwissProtID: Q9P0K8...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Biology Products: