Navigation Links
Investigational ovarian cancer drug shows promise against platinum resistant disease
Date:10/9/2010

A drug being developed as a treatment for ovarian cancer has shown single agent activity with durable disease control in some patients in a Phase-II clinical trial, an international research group has reported.

Dr Ursula Matulonis from Dana-Farber Cancer Institute in the USA reported the results of the single-agent trial of the drug, called MLN8237, in a poster at the 35th Congress of the European Society for Medical Oncology (ESMO).

MLN8237 selectively inhibits an enzyme known as Aurora A kinase, which is a member of a family of kinase enzymes involved in normal cell division. Researchers have found that Aurora A kinase is over-expressed in some cancer cells, leading to growth of cancers.

"In epithelial ovarian cancer, Aurora A kinase has been reported to be frequently upregulated or overexpressed, and associated with worse clinical outcome," Dr Matulonis said. "This is why an effective Aurora A Kinase inhibitor is a potential new therapy to be used alone or in combination with other standard agents such as paclitaxel."

In addition to ovarian cancer, the Aurora A kinase gene is amplified or overexpressed, or both, in other cancers including colon, breast, pancreatic, and bladder cancers, as well as certain lymphomas, leukemias and myeloma.

Unlike other aurora kinase inhibitors currently being studied, MLN8237 selectively targets aurora A Kinase and can be administered orally, Dr Matulonis said.

In the current study, sponsored by Millennium Pharmaceuticals, American, French, Italian and Polish researchers treated 31 patients whose cancer was resistant or refractory to platinum-based chemotherapy and who had tried at least three other therapies. Twenty-five patients had ovarian cancer, 5 had primary peritoneal cancer, and one had Fallopian tube carcinoma.

"The patients enrolled to this study all had progression after platinum-containing regimens which is the mainstay of ovarian cancer treatm
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Investigational immune intervention slows brain shrinkage in Alzheimers patients
2. Initial trials on new ovarian cancer tests exhibit extremely high accuracy
3. TGen finds protein inhibitor revives chemotherapy for ovarian patients
4. Ovarian transplantation restores fertility to old mice and also lengthens their lives
5. Flaxseed-fed chickens shed light on ovarian cancer
6. Spirit of ovarian cancer advocate keeps fundraising drive on track
7. The pill for ovarian cysts
8. Dietary factors influence ovarian cancer survival rates
9. Disarming specialized stem cells might combat deadly ovarian cancer
10. Assessing lead time of selected ovarian cancer biomarkers
11. FDA approved leukemia drugs shows promise in ovarian cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Investigators at Rollins School of Public Health at ... Institute of Technology, have received a $4 million ... Center at Emory University (Health and Exposome Research ... first exposome-based center grant awarded in the United ... by the National Institute of Environmental Health Sciences ...
(Date:5/23/2013)... (May 23, 2013) A new report from the ... helping pupils engage in at least 60 minutes of ... , No more than half of American youth meet ... vigorous or moderate intensity physical activity daily, according to ... children are in school for nearly half of their ...
(Date:5/23/2013)... an age when microbial pathogens are growing increasingly resistant ... a team of Wisconsin scientists has synthesized a potent ... that cause staph infections. , Writing online in the ... group led by University of Wisconsin-Madison chemistry Professor Helen ... sensing" behavior of Staphylococcus aureus , a bacterium ...
Breaking Biology News(10 mins):Emory, Georgia Tech receive first human exposome center grant in US 2Emory, Georgia Tech receive first human exposome center grant in US 3Schools should provide students with daily physical activity, IOM recommends 2University of Wisconsin chemists find new compounds to curb staph infection 2
... South African scientists working at the epicenter of the ... human immunodeficiency virus (HIV) "exhausts" killer T cells that ... HIV can simply "turn off" fully functional T cells ... test tube studies, however, the scientists showed that they ...
... a deadly fish virus detected in the northeastern United States ... probably spread to at least two more. But they have ... death of hundreds of fish in Lake Ontario and the ... month, Cornell's Aquatic Animal Health Program at the College of ...
... ever done finds that the big cats reside in 40 ... ago. The tigers now occupy only 7 percent of ... commissioned by the National Fish & Wildlife Foundation's Save The ... tiger scientists at World Wildlife Fund, Wildlife Conservation Society, the ...
Cached Biology News:How HIV 'exhausts' killer T cells 2How HIV 'exhausts' killer T cells 3How HIV 'exhausts' killer T cells 4Fish virus in Northeast spreading to other fish species 2New tiger report release: Tiger habitat down from just a decade ago 2
(Date:5/24/2013)... May 24, 2013 Quincy Bioscience, ... and development of calcium-binding proteins to support healthy ... safety assessment study of apoaequorin in ... published for the British Industrial Biological Research Association. ... to investigate potential adverse effects, if any, of ...
(Date:5/23/2013)... 23, 2013 Venaxis, Inc. (Nasdaq:   APPY), ... obtaining FDA clearance and commercializing its rapid, protein biomarker-based ... of an underwritten public offering of 10,000,000 shares of ... shares of its common stock at an exercise price ... price of $1.25 per share and related warrant.  Venaxis ...
(Date:5/23/2013)... May 23, 2013 Graphite Metallizing ... self-lubricating bushings mounted in stainless steel pillow blocks. ... of GRAPHALLOY with the application and installation versatility ... Pillow Blocks work exceptionally well when submerged ... hostile liquids such as acids, alkalies, hydrocarbons, black ...
(Date:5/23/2013)... Ind. , May 23, 2013  Rahal Letterman ... in human cord blood stem cell banking and therapeutics, ... of the No. 16 Acorn Stairlifts Indy car driven ... for the remainder of the IZOD IndyCar 2013 season. ... (RLL) will work to support awareness of umbilical cord ...
Breaking Biology Technology:Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 3Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3
... by leading international cardiology societiesTOKYO and INDIANAPOLIS, May ... 38 study applied the new classification system for ... results of the study and showed that patients ... intervention (PCI) and taking prasugrel, as compared with ...
... ,Agendia, a world leader in molecular cancer diagnostics, today ... California San Francisco ,and the Netherlands Cancer Institute will ... Clinical Oncology Annual Meeting, May 29 - June 2,2009, ... study results further underpin the broad predictive and prognostic,power ...
... VIENNA, Austria, May 21 EUCODIS Bioscience, a ... for the,chemical industry, announced today that it has ... of Danisco. Under the terms of the,agreement, EUCODIS ... vivo recombination" to the development of an optimized,version ...
Cached Biology Technology:Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 2Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 3Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 4Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 5Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 6Agendia to Present Multiple Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO Annual Meeting 2Agendia to Present Multiple Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO Annual Meeting 3EUCODIS Bioscience Signs Research Agreement With Genencor 2
... Mung Bean Nuclease catalyzes the degradation of ... 5-phosphoryl terminated products. While the nuclease prefers ... high concentrations the enzyme degrades double-stranded DNA ... has been used for transcript mapping studies ...
Trop-2 Purified Anti-Human clone 162-46, Isotype Mouse IgG 1 , 100 µg Consult technical datasheet for details....
... is used in conjunction with ... of problematic and/or GC-rich templates ... with 10X PCRX Amplification Buffer ... magnesium concentration broader annealing temperature ...
... ZMD.473. Immunogen: Synthetic peptide derived ... mouse junctophilin-2. Specificity: Specific for ... (positive controls: mouse skeletal muscle homogenates ... Applications: Western blotting Immunohistochemistry(froz) ImmunofluorescenceStorage: Store ...
Biology Products: