Navigation Links
Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
Date:12/23/2010

a lot of the heating that your body might [otherwise] experience," said Kachur.

The theory goes that the amount of infrared light can be varied to control the amount of drug that is released from the gold-coated liposomes.

"By using more or less light, you can release more or less of the drug and time the responses as well, so when you trigger light, some drug will leak, you can trigger it again and have more drug leak, or you can wait a little while, let the drug disperse, do its thing, then trigger it again. It allows for a lot more freedom with the release process," said Leung. "By having this very triggered response you can hit that therapeutic window."

Despite increased blood-flow to tumor cells and the key-in-lock action of the ligands, some liposomes may still end up inside healthy cells. In that case, the gold-coating could potentially act to prevent release of the toxic drug to the healthy cells.

By selectively shining the infrared light only in the tumor region, doctors could make sure only liposomes in the tumor region are able to release the drug.

"Once you know where the tumors are, you can go ahead and point your light source toward those areas. Whatever else is left will leave the body or may be slowly released, but not to as high or as toxic of levels as it would be if you just injected the drug systemically," said Leung.

The invention has another bonus: "The gold-coated liposome is biodegradable, which is one of the best parts of our system," said Leung. Currently there are no approved chemotherapeutic treatments that allow the gold nanostructures to be eliminated from the body by the body's own mechanisms, said Leung.

Kidneys, the organs that normally filter waste molecules out of the blood, have a limit as to the size of molecule they can filter. "Because of the size it degrades into, our system should be clearable via the kidney, which is really unique," said Leung.

There st
'/>"/>

Contact: Daniel Stolte
stolte@email.arizona.edu
520-626-4402
University of Arizona
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. UGA licenses invention that kills food-borne pathogens in minutes
2. Tel Aviv University invention busts dust
3. New invention could improve treatment for children with water on the brain
4. Invention helps students learn surgical techniques before operating on patients
5. Vitiligo skin disorder could yield clues in fight against melanoma
6. Saliva proteins could help detection of oral cancer
7. Research about plant viruses could lead to new ways to improve crop yields
8. Nanodiamond drug device could transform cancer treatment
9. UNC study on properties of carbon nanotubes, water could have wide-ranging implications
10. So-called sandfish could help materials handling and process technology specialists
11. Discovery of natural compounds that could slow blood vessel growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
(Date:9/29/2014)... species of gut bacteria called Clostridium ramosum , coupled ... The work is published this week in mBio , ... , A research team from the German Institute of ... gut bacteria including C. ramosum gained weight when ... C. ramosum were less obese even when consuming a ...
(Date:9/29/2014)... a new Food and Brand Lab pilot study, published ... in the National School Lunch Program (NSLP) by 9% ... , Chefs Move to Schools (CMTS), an initiative of ... in order to provide nutrition instruction to students and ... A CMTS event was held in an Upstate New ...
(Date:9/29/2014)... at Washington State University have concluded that nondigestible ... may help prevent disorders associated with obesity. ... assess these compounds in apple cultivars grown in ... of the journal Food Chemistry ., "We ... source of these nondigestible compounds but there are ...
Breaking Biology News(10 mins):Gut bacteria promote obesity in mice 2Chefs move to schools can increase school meal participation and vegetable intake among students 2An apple a day could keep obesity away 2
... New studies released today underscore the potential impact ... of aging, and learning. The research focused on the ... presented at Neuroscience 2013, the annual meeting of the ... emerging news about brain science and health. The ...
... believed that microorganisms that produce methane swim toward the hydrogen ... too hard to prove in the lab. Montana State ... verify it for the first time, said Matthew Fields, an ... a new paper describing the find. In the process, ...
... tyrosine kinases are a large family of cell-surface ... signals, including insulin, growth factors such as epidermal ... and molecules involved in neuronal guidance. Ligand binding ... leading to recruitment of enzymes and adapter proteins ...
Cached Biology News:Research reveals roles for exercise and diet in aging, depression 2Montana State team overcomes challenges, proves that microbes swim to hydrogen gas 2
(Date:9/30/2014)... 30, 2014 Proove Biosciences , ... excited to announce a new genetic test built upon ... Pain Perception Test will provide physicians with an ... pain tolerance levels are stratified between individuals. With this ... a person has a genetic predisposition that will affect ...
(Date:9/30/2014)... , September 30, 2014 ... intuitive browsing of chemistry in documents ... software solutions and consulting services for life science ... information and generate Markush structures from documents. ... organizations intellectual property, however generating and understanding Markush ...
(Date:9/30/2014)... BioHealth Innovation, Inc. (BHI), a ... and increasing access to early-stage funding in ... Tania Fernandez , Ph.D., has joined the BHI ... a member of the management team for a new ... million in seed and early-stage equity investments to therapeutics, ...
(Date:9/30/2014)... 2014 The custom stainless steel fabrication ... Show 2014. The Boston Area Chapter of ISPE (International ... day-long event for Wed., Oct. 1 at Gillette Stadium ... the largest in ISPE Boston’s long history, with more ... attendees expected. , HOLLOWAY AMERICA President David Simpson ...
Breaking Biology Technology:Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3
... Polytechnic Institute have developed a new method to harvest ... the creation of self-powered microsensors for more accurate and ... Koratkar, the researchers investigated how the flow of water ... small amounts of electricity. The research team demonstrated the ...
... , , • NT-KO-003, developed by ... neuroprotective effects that does not cause,immunosuppression. ... administered orally, whereas the few treatments available in,Spain require ... • NeuroAdvan, the Phase IIa clinical ...
... 2011 , Convergence Pharmaceuticals Limited ("Convergence"), ... value analgesic,medicines, today announces that the Phase II proof ... lumbosacral,radiculopathy (LSR) has started. LSR is a ... roots in the lumbar region of the spine. Common,features ...
Cached Biology Technology:New graphene discovery boosts oil exploration efforts, could enable self-powered microsensors 2New graphene discovery boosts oil exploration efforts, could enable self-powered microsensors 3Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 2Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 3Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 4Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 5Convergence Pharmaceuticals Announces Start of Phase II Study for its Selective Nav 1.7 blocker CNV1014802 2Convergence Pharmaceuticals Announces Start of Phase II Study for its Selective Nav 1.7 blocker CNV1014802 3Convergence Pharmaceuticals Announces Start of Phase II Study for its Selective Nav 1.7 blocker CNV1014802 4
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... the yolk protein Vtg in plasma from juvenile ... biomarker for endocrine disrupting chemicals (EDCs) with estrogenic ... an accepted screening test for the estrogenic effects ... EIA kit is a double-antibody immunometric (sandwich) EIA ...
... sequence is from rat SCAMP 5. The sequence of this ... Q - P - Q - T - Q - Y ... Y - T - Y - S - N(233). ... the polyclonal antibody that reacts with this product and the rat ...
... Have a novel target for which no antibody ... made custom antibodies for a variety of pharmaceutical, ... happy to put our technology and expertise in ... Access to our patented RabMAb development technology , ...
Biology Products: