Navigation Links
Invasion of the brain tumors
Date:8/13/2007

Gliomas are highly malignant and invasive tumors with tendrils that extend far from the primary tumor site, rendering conventional therapies ineffective and leading to an invariably poor prognosis. In a new study published online this week in the open-access journal PLoS Biology, Angela Johnston, Donna Senger, and colleagues at the University of Calgary injected immunocompromised mice with human gliomas and compared invasive cells (which left the primary tumor site) to noninvasive cells (which remained at the site of injection) in order to understand the molecular mechanisms underlying this invasive behavior. They identified the neurotrophin receptor p75NTR, which normally functions during development to induce neurite outgrowth and promote neuronal cell death, as an important regulator of glioma invasion. The researchers present the first evidence that this neurotrophin receptor can also be a potent mediator of glioma invasion, and they show that the expression of this receptor is sufficient to impart a dramatic invasive behavior on genetically distinct tumors. These data highlight a previously unknown function of this receptor and suggest it may be a novel therapeutic target in the treatment of this devastating cancer.


'/>"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Chimp genome reveals a retroviral invasion
2. Gene expands malarias invasion options
3. Researchers identify molecular anchor that allows bacterial invasion of central nervous system
4. Exotic crab poised for widespread UK invasion
5. Different strategies underlie the ecology of microbial invasions
6. Whiteflies and plant viruses can help each other to speed up biological invasion
7. Invasion of the island bats
8. Controversial drug shown to act on brain protein to cut alcohol use
9. Drug That Tags Decision-making Areas Of The Brain May Aid
10. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
11. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... ... Biopharma ’s CEO and founder, Dr. Bob Harman DVM, MPVM, is featured in an interview ... Rising Tide". Dr. Harman and Dr. Riordan met in 2003 and have remained in ... of stem cell therapy and a fast friendship was formed. , Dr. Harman has been ...
(Date:9/19/2017)... , Sept. 19, 2017 ValGenesis Inc., ... (VLMS) is pleased to announce the strategic partnership with ... provide clients with validation services using the latest technology ... VTI will provide clients with efficient and cost-effective validation ... marketing partner for the ValGenesis VLMS system. ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... Financial Services (NYS DFS) cybersecurity regulations have transitioned into full force ... organizations operating in the state (“Covered Entities”) to conduct an annual, professional, ...
(Date:9/18/2017)... ... September 18, 2017 , ... Scholarly publisher ... the SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August to a new ... user experience and incorporate a number of enhancements and new features, the website ...
Breaking Biology Technology: